针灸对头臂动脉型大动脉炎患者免疫功能的影响

倪光夏; 石学敏; 韩景献; 高其芳; 阎莉; 蔡刚强; 张新昌; 宋扬扬

doi:10.13702/j.1000-0607.180518

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针灸对头臂动脉型大动脉炎患者免疫功能的影响

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- 针灸对头臂动脉型大动脉炎患者免疫功能的影响
- Effect of Acupuncture Plus Moxibustion on Immune Function in Patients with Bra-chiocephalic Takayasu Arteritis
- 针刺研究 2018年43卷第12期页码：777-780
- 作者机构：
  
  1. 南京中医药大学第二临床医学院
  2. 天津中医药大学第一附属医院针灸部
  3. 天津中医药大学第一附属医院检验科
- 作者简介：
- 基金信息：
  
  国家中医药管理局中医药科学技术研究基金项目(No.00-01LP 53)
- DOI：10.13702/j.1000-0607.180518
  中图分类号：
- 纸质出版日期：2018
- 稿件说明：
移动端阅览
倪光夏, 石学敏, 韩景献, 等. 针灸对头臂动脉型大动脉炎患者免疫功能的影响[J]. 针刺研究, 2018,43(12):777-780.

NI Guang-xia, SHI Xue-min, HAN Jing-xian, et al. Effect of Acupuncture Plus Moxibustion on Immune Function in Patients with Bra-chiocephalic Takayasu Arteritis[J]. Acupuncture research, 2018, 43(12): 777-780.
倪光夏, 石学敏, 韩景献, 等. 针灸对头臂动脉型大动脉炎患者免疫功能的影响[J]. 针刺研究, 2018,43(12):777-780. DOI： 10.13702/j.1000-0607.180518.

NI Guang-xia, SHI Xue-min, HAN Jing-xian, et al. Effect of Acupuncture Plus Moxibustion on Immune Function in Patients with Bra-chiocephalic Takayasu Arteritis[J]. Acupuncture research, 2018, 43(12): 777-780. DOI： 10.13702/j.1000-0607.180518.

摘要

目的:观察针灸对头臂动脉型大动脉炎(BCTA)患者体液免疫和细胞免疫相关指标的影响。方法:对31例BCTA患者进行针灸治疗

以人迎为主穴

并随症配穴

留针20min

每日2次(上下午各1次)

4周为1个疗程

共治疗1个疗程。观察患者治疗前后体液免疫相关指标免疫球蛋白IgG、IgA、IgM、IgE

补体C3、C4和细胞免疫相关指标T淋巴细胞亚群CD3

、CD4+、CD4

、CD8+、CD8

T细胞的变化情况。结果:31例BCTA患者在刚入院未治疗时均给予体液免疫和细胞免疫检测

IgG增高10例

IgM增高3例

IgE增高3例

C3增高11例;CD3+T细胞的变化情况。结果:31例BCTA患者在刚入院未治疗时均给予体液免疫和细胞免疫检测

IgG增高10例

IgM增高3例

IgE增高3例

C3增高11例;CD3

降低11例

CD4+降低11例

CD4

降低7例

CD4+降低7例

CD4

增高6例

CD8+增高6例

CD8

降低4例

CD8+降低4例

CD8

增高9例。所有患者按治疗前的测定结果分组。根据体液免疫指标分为增高组、正常组;根据细胞免疫指标分为增高组、降低组和正常组。针灸治疗后

体液免疫指标增高组IgG、IgM、C3水平均降低(P

0.05)

IgE的变化差异无统计学意义(P

0.05);正常组IgG、IgA、IgM、IgE、C3、C4前后的变化差异无统计学意义(P

0.05)。针灸治疗后

细胞免疫指标增高组CD4+增高9例。所有患者按治疗前的测定结果分组。根据体液免疫指标分为增高组、正常组;根据细胞免疫指标分为增高组、降低组和正常组。针灸治疗后

体液免疫指标增高组IgG、IgM、C3水平均降低(P

0.05)

IgE的变化差异无统计学意义(P

0.05);正常组IgG、IgA、IgM、IgE、C3、C4前后的变化差异无统计学意义(P

0.05)。针灸治疗后

细胞免疫指标增高组CD4

、CD8+、CD8

水平均降低(P

0.05);降低组CD3+水平均降低(P

0.05);降低组CD3

、CD4+、CD4

、CD8+、CD8

T细胞水平均提高(P

0.05);正常组CD3+T细胞水平均提高(P

0.05);正常组CD3

、CD8+、CD8

T细胞水平前后的变化差异无统计学意义(P

0.05)

CD4+T细胞水平前后的变化差异无统计学意义(P

0.05)

CD4

T细胞水平有所降低(P

0.05)

但在正常值范围内。结论:针灸可以降低BCTA患者异常增高的IgG、IgM、C3水平

调整细胞免疫CD3+T细胞水平有所降低(P

0.05)

但在正常值范围内。结论:针灸可以降低BCTA患者异常增高的IgG、IgM、C3水平

调整细胞免疫CD3

、CD4+、CD4

、CD8+、CD8

T细胞紊乱状态

针灸治疗BCTA可能与调节体液免疫及细胞免疫功能相关。Objective To observe the influence of acupuncture and moxibustion on humoral immunity and cellular immunity related indexes in patients with bra-chiocephalic Takayasu arteritis(BCTA)

so as to explore its underlying mechanisms in the treatment of Takayasu arteritis(TA).Methods A total of 31 BCTA patients(9 men and 22 women at age of 16—70 years)were treated by manual acupuncture stimulation of main acupoint Renying(ST 9)and auxillary acupoints as Jiquan(HT 1)

Chize(LU 5)

Fengchi(GB 20)

bilateral Xinshu(BL15)

Feishu(BL 13)and Geshu(BL 17)

Jingming(BL 1)

etc.according to clinical symptoms

with the needles retained for 20 min.Additionally

moxibustion was applied to Taiyuan(LU 9)

BL 15

BL 13 and BL 17.The treatment was conducted twice daily for 4 weeks.Serum IgG

IgA

IgM

IgE

C4 contents

and CD3+T细胞紊乱状态

针灸治疗BCTA可能与调节体液免疫及细胞免疫功能相关。

Abstract

Objective To observe the influence of acupuncture and moxibustion on humoral immunity and cellular immunity related indexes in patients with bra-chiocephalic Takayasu arteritis(BCTA)

Chize(LU 5)

Fengchi(GB 20)

bilateral Xinshu(BL15)

Feishu(BL 13)and Geshu(BL 17)

Jingming(BL 1)

etc.according to clinical symptoms

with the needles retained for 20 min.Additionally

moxibustion was applied to Taiyuan(LU 9)

BL 15

BL 13 and BL 17.The treatment was conducted twice daily for 4 weeks.Serum IgG

IgA

IgM

IgE

C4 contents

and CD3

CD4+

CD4

CD8+

CD8

T lymphocytes contents were assayed by using immue turbidimetry and cell counting.Results Before the treatment and in these 31 BCTA patients

an abnormal increase was found in serum IgG content in 10 cases

IgM in 3 cases

IgE in 3 cases

C3 in11 cases

CD4+ T lymphocytes contents were assayed by using immue turbidimetry and cell counting.Results Before the treatment and in these 31 BCTA patients

an abnormal increase was found in serum IgG content in 10 cases

IgM in 3 cases

IgE in 3 cases

C3 in11 cases

CD4

in 6 cases

and CD8+ in 6 cases

and CD8

in 9 cases

and an abnormal decrease was found in serum CD3+ in 9 cases

and an abnormal decrease was found in serum CD3

level in 11 cases

CD4+ level in 11 cases

CD4

in 7 cases

as well as CD8+ in 7 cases

as well as CD8

in 4 cases.After the treatment

the increased levels of IgG

IgM

CD4+ in 4 cases.After the treatment

the increased levels of IgG

IgM

CD4

and CD8+ and CD8

in patients with abnormally higher values were considerably down-regulated(P

0.05)

the decreased levels of CD3+ in patients with abnormally higher values were considerably down-regulated(P

0.05)

the decreased levels of CD3

CD4+

CD4

and CD8+ and CD8

in patients with abnormally lower values were evidently up-regulated(P

0.05).No significant changes were found in IgG

IgA

IgM

IgE

C3 and C4

CD3+ in patients with abnormally lower values were evidently up-regulated(P

0.05).No significant changes were found in IgG

IgA

IgM

IgE

C3 and C4

CD3

and CD8+ and CD8

in patients with normal values of these indexes after the treatment(P

0.05).The CD4+ in patients with normal values of these indexes after the treatment(P

0.05).The CD4

level in patients with normal value was significantly deun-regulated after the treatment(P

0.05)

but still in the range of normal value.Conclusion Acupuncture plus moxibustion can regulate some of the abnormally elevated and lowered humoral immunity and cellular immunity related indexes in BCTA patients

possibly having a favorable role in the treatment of BCTA.

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