Immunity reaction has been regarded as a key step for clinical acupuncture and moxibustion treatment.In the present paper

we review current situations about studies on acupuncture-moxibustion induced immunoregulation from 1)related project fundings of National Natural Science Foundation(NCFS)of China from 1989—2017;2)papers published in SCI and Chinese medical journals from 2010—2018;3)clinical conditions or disorders treated by acupuncture and moxibustion and their clinical therapeutic effects;4)the commonly used acupoints for studying immune regulation functions;5)some mechanisms of innate immunity and adaptive immunity involved;and 6)immune adjustment pathways involved.Moreover

in our future studies

we suggest to pay more attention to 1)the detailed cellular molecular mechanisms;2)interactions among the immune cells

the immune cells and non-immune cells and cytokines responsible for regulation effects of acupuncture-moxibustion;3)interrelationship of different systems as skin-brain axis

brain-intestinal axis

nerve-blood vessel unit of brain tissues

etc.involving acupuncture-moxibustion induced immunoregulation by using new techniques as proteomics

genomics

two-photon imaging technology

tracer technique

cryo-electronic microscope technology

etc.