Pain

especially chronic pain

can cause multiple changes including sensory-discriminative

emotional-affective

and cognitive-behavior changes and thus greatly affects patients' physical and mental health and quality of life. Therefore

multi-dimensional regulation of paralgesia

cognitive impairment

and negative emotion in patients with chronic pain has become a hot spot in recent studies. The brain regions in the limbic system are involved in the formation and expression of "pain sensation-emotion-cognition". Existing evidence suggests that acupuncture has a multi-dimensional comprehensive regulatory effect on chronic pain

and the brain regions in the limbic system also mediate the analgesic effect of acupuncture. However

further studies are still needed to explore the role and mechanism of action of these brain regions in the multi-dimensional regulation of chronic pain by acupuncture. This article reviews the research advances in the neural mechanism of the limbic system in chronic pain and the role of the limbic system in mediating acupuncture analgesia and mainly elaborates on the mechanism of action of the brain regions in the limbic system in the multi-dimensional regulation of chronic pain.