用玻璃微电极记录方法在清醒麻痹的家兔上探讨扣带回前部 (ACC)痛单位的电活动及其对外周伤害性刺激反应的可能机制。结果发现

ACC的痛单位占引导神经元数的 9.5 % ;其中

痛兴奋神经元 1 2 2个

占痛单位的 81 .3 % ;痛抑制神经元 2 8个

占痛单位的 1 8.7%。除对照组外

大多数痛单位对伤害性刺激的痛反应均明显受受体拮抗剂或激动剂如酚妥拉明、氟哌啶醇、阿托品、地西泮、赛庚啶等的影响。提示 :扣带回前部参与痛信息的管理 ;外周神经及中枢许多相关核团可能通过去甲肾上腺素、多巴胺、乙酰胆碱、γ 氨基丁酸、5 羟色胺或组胺等多种神经递质及相关受体共同调制ACC痛单位的电活动This study using the micro electrode recording method investigated the electric activity of the pain units of the anterior cingulate cortex (ACC) and its response mechanism to peripheral noxious stimulation in conscious paralytic rabbits. The results showed∶ the pain units of ACC amounted to 9.5% of the neurons recorded; among them

PEN was 122 and PIN

28. The pain response of the most pain units to peripheral noxious stimulation was affected apparently by phentolamine

haloperidol

atropine

diazepam

cyproheptadine. The data demonstrate that ACC participates in the management of pain; peripheral nerve and many central nuclei may modulate the electric activity of the pain units of the ACC through norepinephrine

dopamine

acetylcholine

γ amino butyric acid

5 hydroxytryptamine or histamine and its receptors.