本实验采用链脲佐菌素 (STZ)诱发大鼠实验性糖尿病

以坐骨神经中cAMP、cGMP作为检测手段

观察了针刺对糖尿病大鼠的治疗作用。结果显示

糖尿病大鼠 (DM)坐骨神经中cAMP、cGMP含量明显低于正常大鼠 (ND) (P <0 .0 1 )

而给予STZ糖尿病大鼠针刺治疗 4个月后

针刺治疗组 (Ac)坐骨神经中cAMP、cGMP含量与造模组比较有明显差异 (P <0 .0 1 )。提示针刺可防止糖尿病大鼠坐骨神经中cAMP、cGMP含量的下降

对神经轴突的再生与修复有促进作用Intra peritoneal administration of streptozotoxin(STZ) produced diabetes in the Wistar rats. One week after STZ injection the animals were considered to be diabetic rats if the contents of their blood glucose were higher than 16.7 mmol/L.Then the diabetic rats were randomly divided into two groups

diabetic group (DM) without any treatment and acupuncture group (Ac) treated with acupuncture. Four months after treatment the animals were sacrificed and their sciatic nerves were taken out for cAMP and cGMP detection. The concentrations of cAMP and cGMP in the sciatic nerve of rats in DM group were significantly lower than those in age matched non diabetic group (ND) and Ac group (P<0.01

respectively). There was no significant difference between ND and Ac group. The results suggested that acupuncture therapy might prevent the decrease of the contents of cAMP and cGMP in the diabetic sciatic nerve.