In traditional Chinese medicine

the well-known saying that "in the treatment of disorders of the orofacial region

Hegu(LI4)is usually taken" is a highly summary of functions of acupoint LI4

the Yuan-primary point of the Large Intestine Meridian of Hand Yangming. By consulting the related literature and viewing from the angle of differentiation of meridians

the present paper expounded the characteristics of location

the attributed meridian and clinical functions of LI4

and summarized its underlying mechanisms in the treatment of some orofacial disorders revealed by experimental researches. In addition

some examples of clinical application of LI4 were listed

including peripheral facial palsy

oral diseases

problems of the nose and headache.