Objective To observe the effect of transcutaneous electric acupoints stimulation(TEAS) on vascular endothelial function and inflammatory factors after percutaneous coronary intervention(PCI) in patients. Methods A total of 94 patients with coronary heart disease and undergoing PCI were randomized into a TEAS group and a sham-TEAS group

47 cases in each one. In the TEAS group

TEAS started at unilateral Neiguan(PC6) and Ximen(PC4) 30 min before PCI till the end of PCI. In the sham-TEAS group

the procedure and persistent time were same as the TEAS group

but no electric stimulation was performed. Before treatment and at 8 h and 24 h after PCI

the levels of serum endothelin-1(ET-1)

von Willebrand factor(vWF)

nitric oxide(NO)

blood flow dependent diastolic function(FMD)

interleukin-6(IL-6)

inteleukin-10(IL-10)

matrix metalloproteinase-9(MMP-9) and high-sensitivity C-reactive protein(hs-CRP) were detected in the patients successively. Results Compared with the levels before PCI

the levels of ET-1 and vWF were all increased at 8 h and 24 h after PCI in the two groups(P<0.05) and the levels in the TEAS group were remarkably lower than those in the sham-TEAS group(P<0.05). Compared with the levels before PCI

the levels of NO and FMD at 8 h and 24 h after PCI were all reduced in the two groups(P<0.05) and the levels in the TEAS group were higher obviously than those in the sham-TEAS group(P<0.05). Compared with the levels before PCI

the levels of hs-CRP

MMP-9

IL-6 and IL-10 were all increased at 8 h and 24 h after PCI in the two groups(P<0.05); Compared with the sham-TEAS group

the levels of hs-CRP

MMP-9 and IL-6 were reduced and the level of IL-10 was increased at 8 h and 24 h after PCI in the TEAS group(P<0.05). Conclusion TEAS effectively improves the vascular endothelial function and reduces serum inflammatory factors after PCI.