Objective To observe the effects of electroacupuncture(EA) of "Source-"+"Collateral-"acupoints ["Shenmen"(HT 7)+"Zhizheng"(SI 7)] and single acupoints "Neiguan"(PC 6)and HT 7 on cardiac function and myocardial enzymes in acute myocardial ischemia(AMI)rabbits.Methods Sixty Chinchilla rabbits were randomized into normal control

model

Shenmen(HT 7)

Neiguan(PC 6)

HT 7+SI 7 groups

with 8 rabbits in each.AMI model was duplicated by occlusion of the anterior descending branch of left coronary artery under anesthesia.EA(2 Hz

1 mA)was applied to acupoints HT 7

PC 6

and HT 7+SI 7 for 10 min.The maximum ascending rate(+dp/dt max) and maximum descending rate(-dp/dt max)of the left ventricular pressure(LVP)were recorded by using PowerLab System.Serum lactate dehydrogenase(LDH)and creatine kinase MB(CK-MB)contents were detected with chromatometry.Results Serum LDH and CK-MB contents increased significantly in model group than in normal control group(P<0.01).Compared with model group

serum LDH and CK-MB contents decreased remarkably in PC 6

HT 7 and HT 7+SI 7 groups(P<0.01

P<0.05)

and the effects of HT 7+SI 7 group were significantly superior to those of PC 6 and HT 7 groups in lowering serum LDH and CK-MB levels(P<0.01

P<0.05).Compared with the normal control group

+dp/dt max lowered significantly and-dp/dt max increased markedly in the model group(P<0.01)

while compared with the model group

+dp/dt max increased obviously and-dp/dt max decreased significantly in the three EA groups(P<0.01

P<0.05).The effects of HT 7+SI 7 group were markedly superior to those of HT 7 and PC 6 in raising +dp/dt max and lowering-dp/dt max(P<0.05

P<0.01)

and those effects of PC 6 group were evidently better than those of HT 7 group(P<0.05

P<0.01). Conclusion EA of "Source-"+"Collateral-"acupoints(HT 7+SI 7)

HT 7 and PC 6 has a positive effect in improving changes of cardiac function and in lowering serum LDH and CK-MB contents in AMI rabbits

and the effect of EA of HT 7+SI 7 is superior to that of EA of single acupoint.