Parkinson's disease(PD) is a common neurodegenerative disease

and acupuncture has shown potential advantages in the treatment. By analyzing the experimental researches on acupuncture therapy of PD over the past 10 years

the authors find that acupuncture can play a therapeutic role by regulating multiple targets such as basal ganglia neurotransmitter disorder

oxidative stress

abnormal protein folding

immune inflammatory response

apoptosis

neural stem cells and calcium homeostasis. Although the mechanism of acupuncture in the treatment of PD is widely studied

there is still a lack of systematic

in-depth and high-quality research

and the mechanism of acupuncture therapy has not reached a consensus. In the future

the potential mechanisms including mitochondrial dysfunction and intestinal flora should be further studied.