As for an important central regulatory neurotransmitter involving acupuncture effect

serotonin(5-HT)is worthy of being paid with more attention.In the present paper

the authors review development of researches on the involvement of 5-HT and its receptor subunits in pain perception

acupuncture analgesia

and other effects of acupuncture(anti-depression

weight-reduction

etc.).Many studies showed that acupuncture intervention could modulate the content and activity of central 5-HT

and these changes varied under different conditions.Hence

the relationship between 5-HT and other neurotransmitters in acupuncture analgesia and its different functions in different regions of the central nervous system should be considered comprehensively.