Although the basic mechanism of acupuncture-moxibustion has been revealed from many aspects

there are still many shackles in the transformation of the related research achievements. The transformation of academic achievements of experimental acupunctology is an urgent issue to be solved at present. Network regulation is the basic action mode of acupuncture therapy. In the present paper

we proposed that the "acupuncture network drug" could carry a variety of effective active ingredients which may be the core component of network regulation of acupuncture therapy. The "exosomes"

polyvesicle derived from the intracellular lysosomal microparticles invagination

contain complex RNAs and proteins and exist in the body fluids and function in secreting abundant activate substances to participate in intercellular communication

which is the research hotspot in the field of frontier life science in the world. They play an important role in the diagnosis and treatment of diseases

and drug development

etc.. Our studies using rats with adjuvant arthritis and mice with sepsis displayed that after intraperitoneal administration of serum exosomes derived from normal animals receiving acupuncture intervention

an acupuncture-like analgesic effect and an anti-inflammatory effect were achieved

respectively. It is thus possible that acupuncture network drugs could be developed from serum exosomes secreted by exosome autogenous living cells after acupuncture intervention by virtue of the characteristics of low immunogenicity and may have great advantages in drug development and modification. It is also expected to provide new ideas for the transformation of experimental research results and to in depth give explanations about the underlying mechanisms of acupuncture therapy.