Objective To observe the effect of electroacupuncture(EA)stimulation of"Zusanli"(ST 36)and"Zhongwan"(CV 12)on blood-lipid

high-sensitivity C-reactive protein(HS-CRP)and adiponectin(ADPN)levels in hyperlipidemia rats

so as to study its mechanisms underlying improvement of hyperlipidemia.Methods Thirty-two male Wistar rats were randomly divided into control group

model group

manual acupuncture group and EA group(n=8in each group).Hyperlipedemia model was established by feeding the rats with high fat diet for 40days.Manual acupuncture and EA stimulation were separately applied to unilateral"Zusanli"(ST 36)and"Zhongwan"(CV 12)

once daily for 4weeks.Serum triglyceride(TG)

total cholesterol(TC)

high density lipoprotein cholesterol(HDL-C)

low density lipoprotein cholesterol(LDL-C)levels were determined by chromatometry

and serum HS-CRP and ADPN contents detected by immunity turbidimetric method and euzymelinked immunosorbent assay

respectively.Results Compared with the control group

serum TC

TG

LDL-C and HS-CRP levels were significantly upregulated in the model group(P<0.05

P<0.01)

while serum HDL-C and ADPN levels remarkably reduced after modeling(P<0.05

P<0.01).In comparison with the model group

serum TC

TG

LDL-C and HS-CRP contents were considerably decreased in both manual acupuncture and EA groups(P<0.05

P<0.01)

and serum HDL-C and ADPN contents were evidently upregulated in the manual acupuncture and EA groups(P<0.05

P<0.01).The effect of EA in decreasing serum TC

TG

LDL-C and HS-CRP

and increasing serum ADPN was superior to that of manual acupuncture(P<0.05).Conclusion EA intervention has a remarkably positive effect on hyperlipidemia by reducing serum TC

TG

LDL-C and HS-CRP contents and upregulating serum HDL-C and ADPN levels in hyperlipidemic rats.