Objective To observe the effect of electroacupuncture(EA)stimulation of"Fenglong"(ST 40)on celiac inflammatory factors in rats with hyperlipemia(HLP)

so as to reveal its mechanism underlying improvement of HLP.MethodsA total of 40 SD rats were randomized into normal control

high fat forage

high fat+common forage

high fat+EA

and high fat+common forage+EA groups

with 8rats in each group.The HLP model was established by feeding the animals with high fat forage for 28 days.EA(2mA

2Hz/100Hz)was applied to bilateral ST 40 for 30min

once daily for 28 days.Contents of plasma total cholesterol(TC)

triglyceride(TG)

low-density lipoprotein cholesterol(LDL-C)

high-density lipoprotein cholesterol(HDLC)were detected by using an automatic biochemistry analyzer.Intercellular adhesion molecule-1(ICAM-1)

monocyte chemoattractant protein 1(MCP-1)

and interleukin-1γ(IL-1γ)in macrophages of the abdominal cavity were detected using flow cytometry(FCM).Results Compared with the normal control group

the contents of plasma TC and LDL-C

and celiac macrophages' MCP-1

ICAM-1and IL-1γcontents were significantly increased in the high fat forage group and high fat+common forage group(P<0.01).In comparison with the high fat forage group

contents of plasma TC and LDL-C

and macrophages' MCP-1

ICAM-1and IL-1γwere considerably down-regulated in the high fat+EA group(P<0.01).Similarly

the levels of plasma TC and LDLC

and macrophages' MCP-1

ICAM-1and IL-1γwere obviously lower in the high fat+ common forage+EA group than in the high fat+common forage group(P<0.01).No significant differences were found in plasma TG and HDL-C levels among the five groups(P>0.05).Conclusion EA stimulation of"Fenglong"(ST 40)has a role in down-regulating contents of plasma TC and LDL-C and celiac macrophages' MCP-1

ICAM-1and IL-1γin the abdominal cavity in hyperlipemia rats

which may contribute to its effect in improving hyperlipemia.