Objective To investigate short-and long-term benefits and safety of acupoint injection of kakkonein for early-or mid-stage Parkinson's disease(PD).Methods A total of 135 patients with early-or mid-stage PD were enlisted and 116 cases completed the observation

including 40 cases in the acupoint-injection group

37 cases in the acupuncture group and 39 cases in the medication group.Patients of the acupoint-injection group were treated by injection of kakkonein(2mL)into bilateral Fengchi(GB 20)

once very other day for 8weeks.For acupuncture intervention

bilateral GB 20 acupoints were punctured with filiform needles

once every other day for 8weeks.Patients of the medication group were treated by oral administration of compound levodopa(125mg/time

twice a day)for 8weeks.The disease severity was assessed by using Unified Parkinson's Disease Rating Scale(UPDRS

version 3.0)before and after treatment

and one month after the treatment.Results After the treatment

scores of psychosis

behavior and emotion

daily life activity and motor function were all significantly decreased in the three groups in comparison with pre-treatment in each group(P<0.05)

suggesting an improvement of the PD patients' conditions.The therapeutic effect of acupoint-injection and acupuncture groups was markedly superior to that of the medication group(P<0.05).One-month's follow-up showed that the scores of behavior-emotion and daily life activity were obviously lower in the acupoint-injection group than in the acupuncture and medication groups(P<0.05).No significant differences were found between the acupuncture and medication groups in down-regulating scores of behavior-emotion

daily life activity and motor function(P>0.05).Conclusion Acupoint injection of kakkonein can improve patients' behavior

emotion

and daily life activity in early-or mid-stage PD patients and has both short-and longer-term benefits.