Objective To observe the curative effect of acupoint-injection and intramuscular-injection of Bacillus Calmette-Guerin(BCG)Polysaccharide Nucleic Acid for bronchial asthma.Methods Sixty patients with bronchial asthma were equally randomized into acupoint-injection group and intramuscular-injection group.For patients of the acupoint-injection group

2mL of BCG was injected into bilateral Feishu(BL 13

1mL for one side)once per day in the first 15 days

and once every other day in the rest 2.5months except weekends.Intramuscular-injection was conducted at the lateral sites of the left or right buttock

2mL/time for each site

and the injection frequency was the same to that of the acupoint-injection.The therapeutic effect was assessed according to the standards of Guide Principles for Clinical Research of New Chinese Herbal Drugs(2002)and Asthma Group of Breathing Diseases of China Medical Association(2008).Changes of FEV 1(forced expiratory volume in the first second)/FVC(forced vital capacity)and PEF%(peak expiratory flow)were detected using apulmonary function detector.Serum IgA

IgM

IgG and IgE contents were assayed by using an autonomic biochemical analyzer.Results After 3months' treatment

the scores of patients' symptoms and signs and serum IgE and IgG levels were significantly decreased in both muscular-injection and acupoint-injection groups(P<0.01)

while asthma controlled test(ACT)scores FEV 1/FVC% and PEF% values were considerably increased in both groups compared to pre-treatment in the same one group(P<0.01).The effects of acupoint-injection were markedly superior to those of the intramuscular-injection in reducing clinical symptom-sign score

and serum IgE content

and in up-regulating ACT score

FEV 1/FVC% and PEF%levels(P<0.05

P<0.01).There were no significant differences in serum IgG

IgA and IgM levels between the two groups 3months following the treatment(P>0.05).Conclusion Acupoint-injection of BCG polysaccharide nucleic acid can effectively improve bronchial asthma patients' clinical symptoms and sings and pulmonary function

which may be closely associated with its function in down-regulating serum IgE and IgG levels.