Objective To observe the effect of electroacupuncture(EA)stimulation of"Yifen"(TE 17)

"Shenshu"(BL 23)on the expression of 5-hydroxytryptamine receptor 1B(5-HTR 1B)mRNA and 5-hydroxytryptamine receptor 2C(5-HTR2C)mRNA in the cochlear nucleus tissue in mice experiencing radiation from mobile phone

so as to explore its mechanisms underlying improvement of tinnitus.Methods Thirty Kunming mice were randomly divided into control group(n=6)and modeling group(n=24).The tinnitus model was established by giving the mice with mobile phone-radiation for 1hin the morning and 1h in the afternoon

continuously for 40 days.EA stimulation was applied to"Yifeng"(TE 17)group(n=6)and"Shenshu"(BL 23)group(n=6)for 20 min

once a day for 7days.The expression of 5-THR 1B/2CmRNA in the cochlear nucleus was assayed by fluorescence quantitative polymerase chain reaction(real time-PCR).Results The expression level of 5-HTR 1Bwas significantly lower in the model group than in the control group(P<0.05)

while that of 5-HTR 2C mRNA significantly increased(P<0.01).TE 17 group received a significant acupoint intervention effect(P<0.01).Compared with TE 17 group

BL 23 group received a weaker effect(P<0.05).Conclusion EA of TE 17 can up-regulate expression level of 5-HTR 1Band downregulate expression level of 5-HTR 2Cin the cochlear nucleus in mice experiencing mobile-phone radiation.