针刺减少噻唑烷二酮类降糖药所致体质量增加的中枢摄食相关机制探讨

景欣悦; 偶晨; 卢圣锋; 朱冰梅

doi:10.13702/j.1000-0607.2015.06.016

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针刺减少噻唑烷二酮类降糖药所致体质量增加的中枢摄食相关机制探讨

思路与方法 | 更新时间：2023-08-11

- 针刺减少噻唑烷二酮类降糖药所致体质量增加的中枢摄食相关机制探讨
- Acupuncture Intervention Reduced Weight Gain Induced by Hypoglycemic Agents through Food Intake-related Targets in Central Nervous System
- 针刺研究 2015年40卷第6期页码：510-513
- 作者机构：
  
  南京中医药大学针药结合省部共建教育部重点实验室
- 作者简介：
- 基金信息：
  
  国家自然科学基金(No.81303018、81273838);江苏省高校自然科学基金(No.13KJB 360006)
- DOI：10.13702/j.1000-0607.2015.06.016
  中图分类号：
- 纸质出版日期：2015
- 稿件说明：
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景欣悦, 偶晨, 卢圣锋, 等. 针刺减少噻唑烷二酮类降糖药所致体质量增加的中枢摄食相关机制探讨[J]. 针刺研究, 2015,40(6):510-513.

JING Xin-yue, OU Chen, LU Sheng-feng, et al. Acupuncture Intervention Reduced Weight Gain Induced by Hypoglycemic Agents through Food Intake-related Targets in Central Nervous System[J]. Acupuncture research, 2015, 40(6): 510-513.
景欣悦, 偶晨, 卢圣锋, 等. 针刺减少噻唑烷二酮类降糖药所致体质量增加的中枢摄食相关机制探讨[J]. 针刺研究, 2015,40(6):510-513. DOI： 10.13702/j.1000-0607.2015.06.016.

JING Xin-yue, OU Chen, LU Sheng-feng, et al. Acupuncture Intervention Reduced Weight Gain Induced by Hypoglycemic Agents through Food Intake-related Targets in Central Nervous System[J]. Acupuncture research, 2015, 40(6): 510-513. DOI： 10.13702/j.1000-0607.2015.06.016.

摘要

噻唑烷二酮类降糖药(TZDs)导致2型糖尿病患者体质量增加甚至肥胖的不良反应限制了其临床应用和推广。针刺已经成为一种较为有效的治疗肥胖的手段

本文从中枢神经系统摄食相关靶基点出发

认为针刺可能通过改变血脑屏障的通透性从而影响TZDs的入脑量或影响下丘脑摄食相关的过氧化物酶体增殖物激活受体γ、瘦素及神经肽Y的活性及表达

抑制摄食

进而减少TZDs所致体质量增加。

Abstract

Clinical practice shows that thiazolidinediones(TZDs)induce weight gain in patients with type-Ⅱ diabetes mellitus during treatment

which restrains its application and generalization clinically.It has been demonstrated that acupuncture therapy is useful in easing obesity in clinical trials.In the present paper

we summarize the underlying mechanism of weight gain induced by TZDs through food intake-related targets in the central nervous system and analyze the possible effects of acupuncture therapy.Acupuncture therapy is expected to reduce weight gain side effect of TZDs through 1)lowering permeability of blood brain barrier to reduce TZDs concentration in the brain

2)upregulating the expression of hypothalamic leptin and inhibiting hypothalamic neuropiptide Y expression

and 3)down-regulating activities of peroxisome proliferator-activated receptor to reduce energy intake and fat syntheses.

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