Objective To observe the effect and safety of injection of vitamin B1 into Zusanli(ST36) and Hegu(LI4) in the treatment of functional dyspepsia(FD). Methods A total of 100 FD patients were equally divided into medication group and acupoint injection group(n=50/group) according to a random number table. Patients in the medication group were ordered to take mosapride citrate tablets(5 mg) orally 30 min before each of the three meals

while those in the acupoint injection group received injection of vitamin B1 into ST36 and LI4

once every other day

three times a week. One week later

the clinical symptom scores

total effective rates

serum gastrin(GAS) and plasma motilin(MTL) contents

and gastric emptying rates between the two groups were compared

followed by the observation of adverse reactions. Two weeks' follow-up survey was conducted after the end of treatment

and the clinical symptom scores and total effective rates of the two groups were further compared. Results Compared with the data before treatment in the same one group

the clinical symptom scores and serum GAS contents of post-treatment as well as the follow-up symptom scores were all significantly decreased(P<0.05

P<0.01)

while the plasma MTL levels and gastric emptying rates were obviously increased in both groups(P<0.01). Comparison between the two groups showed that the clinical symptom score

serum GAS content after the treatment and follow-up symptom score were considerably lower(P<0.01)

but the total effective rate

plasma MTL

gastric emptying rate after the treatment and total effective rate of follow-up notably higher in the acupoint injection group than those in the medication group(P<0.01

P<0.05). Conclusion Injection of vitamin B1 into ST36 and LI4 is effective in improving symptoms of PD patients

which may be related to its functions in regulating the levels of GAS and MTL in blood

and facilitating gastrointestinal motility.