The nervous system is the necessary condition for inducing the curative effect of acupuncture. Both the sympathetic and vagal nerve systems are widely distributed throughout the body and organically connect various systems and organs of the human body. In maintaining the coordination and unity of human physiological activities

it is in line with the holistic view and bidirectional regulation of acupuncture

and fits in with the meridian theory of “internally belonging to the Zang-fu organs and externally connecting with the limbs and joints”. Acupuncture

one of the body surface stimulation therapies

can inhibit the inflammatory response via activating sympathetic/vagus nerve mediated anti-inflammatory pathways. The peripheral nerve innervating diffe-rent acupoints determines the different anti-inflammatory pathways of the autonomic nerve

and different acupuncture methods(stimulation form and stimulation amount) are important factors affecting the anti-inflammatory mechanism of the autonomic nerve. In the future

we should analyze the central integration mechanism between sympathetic nerve and vagus nerve regulated by acupuncture at the level of brain neural circuits

and clarify the “multi-target” advantage of acupuncture

so as to provide inspiration and reference for the study of neuroimmunological effects of acupuncture.