Wound is a common surgical disease characterized by skin defect or functional limitation. Studies have found that acupuncture-moxibustion plays an important role in wound healing. In this paper

we reviewed the mechanisms of acupuncture-moxibustion in promoting wound repair. Outcomes display that acupuncture-moxibustion has an action in promoting wound restoration by improving wound flow perfusion

promoting angiogenesis

increasing the number of fibroblasts and regulating collagen synthesis. In addition

acupuncture can effectively promote wound healing by controlling the release of inflammatory cytokines

up-regulating the expression of growth factors such as vascular endothelial growth factor and transforming growth factor-β1

and affecting phosphatidylinositol-3-kinase/protein kinase B

mitogen-activated protein kinase and advanced glycation end products/receptor for AGEs signaling pathways. Based on the above studies

it is highly recommended that future studies should pay more attention to the multi-mechanism coordinated regulation target center

and the therapeutic means and dose-effect relationship of acupuncture-moxibustion in tissue repair.