Inflammatory reaction after spinal cord injury(SCI) is the main obstacle to the recovery of neural function. In the occurrence and development of SCI

the complex regulatory mechanisms are involved in inflammatory reaction

including the activation of inflammatory cells(e.g.macrophages and microglia)

and the release of cytokines(e.g. tumor necrosis factor

interleukin and chemokines). Acupuncture-moxibustion is significantly effective in clinical treatment of SCI

and its mechanism is related to adjusting the function of inflammatory cells after SCI

modulating the expression of cytokines and the activation of NLRP3 inflammatory bodies

as well as the expression of high mobility group protein B1 and calcitonin gene related peptide. This article summarizes the research progress of mechanism of inflammatory reaction after SCI and the effects of acupuncture-moxibustion intervention in recent years so that the new ideas can be provided to clarify the pathogenesis of SCI and the effect of acupuncture-moxibustion intervention.