最新刊期
1984年第1期
- 摘要：神经系统的诱发反应常常被自发的神经活动所掩盖。过去用阴极射线示波器扫描重叠方法可以使诱发反应在杂乱的自发反应(干扰)的背景上显示出来,但这个方法不能减低干扰水平。在体感诱发电位记录方面,近代进展,产生了无损伤技术,用来测定神经系统从外周到皮层的各种电活动。该技术的创始人Dawson首先设计了从头皮电极引导诱发电位的自动累加平均方法。使诱发电位能从不规则出现的自发脑电波动中提取出来。而近代电子计算机技术的发展与应用,使累加诱发电位技术更趋完善。用累加技术所得的诱发反应比用多The summation technique appearing in 1950's has now been one of the important techniques for research on neurophysiology and pathology, and begun to be used in clinic. There are several kinds of average evoked pote- ntials. In the present paper emphasis is placed on somatosensory evoked potentials (SEP). The factors influencing SEP, the expression of SEP of the patients with lesion of neural system, the research advance of this te- chnique on finding a small brain lesion and the development of a method for objective pain measurement are briefly introduced in this paper. At last, the neurophysiologic mechanism of SEP is briefly introduced.787|0|0更新时间：2023-08-11
- 摘要：目前,我院施行心脏二尖瓣闭式扩张术主要采用普鲁卡因静豚复合、吗啡静脉复合和针刺复合三种麻醉法,认为针刺复合法是这类手术可供选择的较好方法之一。现就采用本法的67例临床资料,将我们的方法和体会报道如下: 临床资料 67例中,男33例,女34例。年龄为18～50岁,40岁以上者6例。出现临床症状距手术时间最短一年,最长18年;10年以上者14例。心脏功能Ⅱ级47例,Ⅲ级18例,Ⅳ级2例。术前并有房颤者2例。手术This paper reports on the result of closed mitral commissurotomy of 67 cases under acupuncture anesthesia. The age of patients ranged 18～50 with 6 above 40 years. Symptoms lasted 1～18 years, 14 cases being above 10 yeays. There were 20 patients with cardiac function Ⅲ or Ⅳ. The procedures of anesthesia consisted of: (1) Preoperatively 10 mg. morphine and 0.3 mg. Scopolamine; (2) Electric stimulation at two acupu- ncture points, "Hegu" and "Binao"; (3) Intercostal nerve block of 3 inter- costal spaces with about 10～15 ml of 1～2% procaine; (4) Conscious endo- tracheal intubation with controlled breathing. By observations on the heart rate, blood pressure, arterial blood gas analysis and the effect of acupuncture anesthesia, it was suggested that the actions of electric acupuncture were mainly in two aspects: (1) analgesia, with individual variations in intensity, would give a good anesthetic effect if it was coupled with electric stimulation, appropriate analgesic agents and intercostal nerve block. In the present series, there were 62 successful cases (92.5%), and only 5 failure cases (7.5%); (2) It enhanced cardio- vascular functions. There was no serious arrhythmia except occasionally occurring extrasystole during direct operative stimulation to the heart. The incidence of low B. P. (lower than 80mmHg)and low pulse-pressure(20mmHg) was less frequent than in combined intravenous procaine anesthesia. Also there was no hypertension and tachycardia throughout the operation. This was consistent with the research findings from the Department of Physiology of the First Shanghai Medical College that electric acupuncture could alleviate the blood loss and the hypotension induced by the traction reaction of the visceral organs, and had a marked hypotension action on experimental acute hypertension. It could also inhibit the extra-systloe induced by stimulation of the hypothalamus. Considering the pathologico-physiology of pulmonary and circulatory system in mitral stenosis, after opening the chest, we used the controlled respiration for the patients. It was safe and its advantages were: (1) PaO_2 increased (above 300 mmHg), PaCO_2 decreased (20.5～39.3 mmHg); (2) No mediastinal flutter; (3) Better maintenance of respiratory and circu- latory functions; (A) Oxygen consumption raduced due to excessive aute breathing; (5) Throughout the operation, patients appeared calm because there was no anoxemia. In conclusion, acupuncture anesthesia was the method of choice for closed mitral commissurotomy. But the technique of conscious endotracheal intubation must be performed skillfully and lightly. However, for nervous patients and patients with poor heart functions, acupuncture anesthesia should be used cautiously.758|0|0更新时间：2023-08-11
- 摘要：为了弄清暗示在循经感传中的作用这一问题,我们先后进行了四项观察,结果如下: 1.在以电针穴位引起的感传多次强化视觉和听觉暗示信号之后进行检查,14名感传显著者有13人对暗示单独作用都不能引起感传; 2.对30名第一次接受针刺治疗的思者给以强烈暗示,不能引出感传; 3.50名感传显著者中的大多数人在长期的观察过程中都出现过进针以后无感传,需要采取调整针位,加大刺激强度等措施才902|0|0更新时间：2023-08-11
- 摘要：Since March 1980,the CDM Type-V Acupuncture Anesthesia Apparatus(AAA) with analysing parameters (hereafter called Type-V in this paper)was used by the authors in tooth extractions in 161 cases,which yieldedgood effects. The main data were compared to those obtained by using theCDM Type-Ⅱ AAA in 298 cases on tooth extractions and analysed as fol-lows: (Ⅰ)THE CHARACTERISTICS OF TYPE-V The apparatus has recording and parameter analysing functions by theelectric multi-stimuli in the practices of acupuncture and acupuncture ane-632|0|0更新时间：2023-08-11
- 摘要：本工作用核团内微量注射海人酸,特异性毁损神经细胞的方法,观察大鼠延脑后端腹外侧部和蓝斑在电针镇痛中的作用。体重180～220克雄性大白鼠,脑内埋置外径0.71毫米的纲管至预定注药部位上方1.5毫米处,作为引导管;插入外径0.4毫米的注药管至双侧延脑后端腹侧(含A_1细胞群部位)或蓝斑。上述动物随机分为实验组和对照组。实验组注射海人酸(溶于0.2M,PH7.4磷酸盐缓冲液),双侧注射,每侧0.25微克/0.25微升,2分钟注完。对照组注等量磷酸盐缓冲液。脑内注射后48至60小时间测基础痛阈、观察电针的镇痛效应。电针取双侧“足859|11|0更新时间：2023-08-11
- 摘要：This article reports the experimental design,method and result relatedto the preoperative period of the veterinary anesthesia by laser. Accordingto the specific properties of laser and in order to use the laser techniquein the veterinary clinic, we have screened and drafted the acupoint groupfor animal anesthesia by laser. Jiaji acupoint group on the basis of traditional collateral channeldoctrine of Chinese veterinary and the modern animal neuroanatomico-677|5|0更新时间：2023-08-11
- 摘要：自提出经络现象与肥大细胞有关以来,不少学者观察到,电针刺激能引起穴位局部结缔组织中肥大细胞的脱粒反应。而肥大细胞在机体内分布极广,数量极多,并能产生多种生物活性物质。据报导,针刺“足三里”,循足阳明胃经能引起胃肠道蠕动的变化。设想电针刺激“足三里”对分布于胃肠系统腹膜腔的肥大细胞产生形态结构的影响。材料与方法实验选用体重200～300克的雄性大白鼠。实验分三组:甲组:电针刺激后肢“足It has been proved that electro-needling of acupoints might lead to the degranulation of mast cells in connective tissue. The morphological changes in rat's peritoneal mast cells under electro-acupuncture at point "Zusanli" were observed in this experiment. This experimental study were carried out on 3 groups: Group A, electro-acupuncture at point "Zusanli"; Group B, electro- acupuncture at point "Neiguan"; and Group C, no electro-acupuncture, as controls. The result of this experiment was as follows: 1. Light microscope observation: The peritoneal mast cells with degranulation in group A occurred 70.07 ±2.73 per cent; in group B 54.93±2.81 per cent; in group C 35.6±2.68 per cent. Marked difference among three groups was found. It seems that point "Zusanli" might possess relative specificity. 2. Electro-microscope observation: The degranulation process shown by transmission electro-microscope occurs by the well known pathway of exocytosis. Simultaneously the alte- ration of granular structure and the obviousness of rough surfaced endopla- smic reticulum can be observed. Mast cells synthesize a number of mediators, mainly histamine, hepa- rin, and serotonin (5-HT) etc. The release of these substances is accompa- nied by the extrusion of cellular granules. We postulate that this regula- ting mechanism of acupuncture might be triggered by these substances.973|0|0更新时间：2023-08-11
- 摘要：70年代以来,许多学者认为肌梭是肌肉丰厚处穴位内针感感受器,因而对肌梭的研究颇为广泛。我们也曾对穴位内肌梭的微细结构进行了论述。为进一步探讨针麻原理及配合肌肉移植后其功能恢复的研究,本文又对人涌泉穴区内肌梭的超微结构进行了观察。材料和方法材料取自20例病人截除下肢涌泉穴深部的足蚓状肌,稍伸展后系于玻棒上,前固定于预冷的2％多聚甲醛——2.5％戊二醛磷酸缓冲液中24小时(2～4℃),磷酸缓冲液(pH7.2～7.4)浸洗数小时,将蚓状肌切成2～3段,每段用半导体冷冻切片机纵切The ultrastructure of the muscle spindles obtained from the area of 20 human Yongquan points was observed by transmission and cryofracture scanning electron microscope. It was revealed that capsule of the muscle spindle was divided into outer and inner layers by a subcapsular space, while the outer capsule was consisted of more than ten layers of flattened membranous fibroblasts and collagenous fibrils between them, and the inner capsule was only consisted of several extremely flattened fibroblasts surro- und every intrafusal muscle fiber. The intrafusal muscle fibers may be di- vided clearly into nuclear bag and nuclear chain fibers by both TEM and SEM. The primary sensory endings on the nuclear bag region of the nuclear bag fibers were partially covered by two lips of sarcolemma, while those located on the nuclear chain fibere were not. Satellite cells on the myotube region of the nuclear bag fibers were demonstrated.Small vascular and capil- laries were found both in the outer capsule between membranous layers as well as in the subcapsular cavity.783|0|0更新时间：2023-08-11
- 摘要：上丘为一古老的分层结构。一些解剖学和生理学资料证明,上丘浅层和深层有着不同的纤维投射,其浅层主要接受视网膜和纹状皮质的输入,而深层除与视觉有关外,还是各种感觉的会聚地带。近来Edwar-ds通过形态学研究证明上丘广泛接受视结构、听结构、体感觉结构、儿茶酚胺神经核团以及特殊网状区的输入,从而认为上丘深层具有脑干中心网状结构的性质。已知脑干网状结构与针刺镇痛作用有关,而上丘也有人认为涉及到痛觉机理,因而了解上丘与脑内有关疼痛和镇痛的某些结构之间的联系是很有必要的,这对针刺镇痛The connections between superior colliculus and some nociceptive and anti-nociceptive nuclei in the cat brain were studied by a combined antro- grade and retrograde tracing technique. Following HRP injections into the superior colliculus, both HRP-posi- tive cells and labeled terminals were found in the zona incerta, mainly ipsilaterally. when HRP was injected into rostral superior colliculus, a number of labeled terminals might be observed in the zona incerta, but did not show and labeled cells there. After HRP injections into rostral-middle region of superior colliculus, retrograde labeled cells were presented densely in the ipsilateral zona incerta, but labeled terminals were considerably sparse. Following HRP injections into the caudal superior colliculus, there were little labeled terminals, but labeled cells presented mildly. In spite of the site of superior colliculus where the HRP was injected, labeled cells were generally found in ventral division of thalamic reticular nucleus but clearly in decreased number. In the cases in which only the rostral superior colliculus was injected, the labeled (terminals) were observed in caudal part of thalamic reticular nucleus, thalamic parafascicular nucleus and centromedian nucleus, mainly ipsilaterally. In addition, a large amount of labeled cells were found in ipsilateral reticular part of substantia nigra and contralateral nucleus tractus spinalis trigemini oralis γ, but lateral part of substantia nigra, the ventral and lateral division of periaquaeductal gray substance, nucleus of locus caeruleus, subcaeruleus, raphe nuclei of midbrain, and subnucleus ventralis of contralateral nucleus trigemini sensiblis princi- palis contained a few of HRP-positive cells. It is suggesting that the connections between superior colliculus and nociceptive and anti-nociceptive structures in the cat are considerably abundant. We propose that these con- nections may be considered as the morphological bases of noxious and anti-noxious sensory input.921|0|0更新时间：2023-08-11
- 摘要：1971年Maroko。等通过实验证实结扎冠状动脉后15分钟,心外膜心电图ST段升高的平均值(ST)及升高值总和(∑ST)和ST段升高的导联数(NST)与24小时心肌细胞损伤的严重程度及梗塞范围直接平行,认为心外膜心电图特别在急性心肌缺血的早期,能准确定量地反映心肌缺血的程度。为了进一步开展中西医结合治疗冠心病,急性心肌梗塞的研究,本实验应用心外膜心电图ST升高均数(ST)和导联数 (NST)作为急性心肌缺血的指标,在结扎犬的冠状动脉左前降支(LAD)造成急性心肌梗塞的实验模型上,观察针刺的疗效和穴位的相对特异性。1088|0|0更新时间：2023-08-11
- 摘要：本工作的目的是观察在循经感传过程中,皮肤血流图的改变是否具有循经的特征。观察对象为10例循经感传显著的成年人,对照组为15例无感传者和18例未作针刺的静卧对照,针刺穴位为右内关,观察经脉为右心包经的前臂段。分别在腕横纹上6厘米和18厘米的两个平面上各取三个点(感传线及共两侧旁开对照各一点),测定局部阻抗血流图。信号通过叠加仪平均加算,观察结果:(一)血流图的振幅:针后血流图的振幅增大,感传线上的增大值大于对照线。无感传者的经线增大值则小于对照线,但P值均>0.05。如排除静卧时血流957|0|0更新时间：2023-08-11
- 摘要：神经解剖学家Peele认为胃和肠的感觉纤维位于迷走神经和交感神经中,但痛觉冲动主要由交感神经传导,恶心感觉则由迷走神经传递,饱满感和胃充实感亦然。Ca-rpenter叙述了内脏有许多传入纤维(包括有髓鞘和无髓鞘两种),内脏痛从腹部至盆腔脏器主要是通过交感神经传入的,迷走神经感觉纤维则关系到内脏运动和分泌反射等。此外,Ranson和Billingsley等神经解剖学家对内脏感觉纤维的论述和Peele及Carpenter等是一致的。至于交感感觉纤维的胞体位于脊神经节的问题已为诸学者所公认。从临床实践证明内脏的痛觉及The posterior wall of stomach in 9 rabbits, the anterior wall of sto- mach in 6 rabbits, the pylorus in 9 rabbits and the cardia in 10 rabbits were used. In each animal 80～100 ul of 10% horseradish peroxidase (HRP, sigma Ⅵ) solution was injected into the tunica serosa of the stomach. After survival of five days, the animals were sacrificed and their he- arts were perfused with 2% paraformaldehyde soluted in 0.1 M phosphate acid buffer (pH 7.2～7.3). The spinal ganglia were treated according to HRP method and incubated in 3-3 diaminobenzidine (DAB) H_2O_2 solution. The distribution of the HRP labeled cells were examined under light micro- scope and results were as follow: After injection into the tunica serosa of anterior and posterior wall of stomach, we could find clearly labeled cells appearing in the total thoracic spinal ganglia (T 1～12) as well as cervical spinal ganglia four to eight (C 4～8), and lumbar spinal ganglia one to seven (L 1～7). Thoracic spinal ganglia T 5～9 were the segments where the labeled cells were most nume- rous, less in the cervical ganglia, and least in the lumbar ganglia. After the HRP was injected into the pyloric region, we could find la- beled cells appearing in the thoracic spinal ganglia one to twelve (T 1～12) and lumbar spinal ganglia one to four (L 1～4). When the HRP was injected into the cardiac region, labeled cells could be found cervical spinal ganglia 4～8 (C 4～8) and thoracic spinal ganglia 1～12 (T 1～12), but in the least number. Moreover, it was found that the labeled cells were of different sizes and that labeled cells were mainly small cells, with comparatively less large cells. The above experimental study further suggested that the segment of the sympathetic afferent fibers of the stomach was longer.It also provided a morphological foundation for explanation of the theory of the somato- viscera interrelated connections.900|0|0更新时间：2023-08-11
- 摘要：本文观察了循经感传显著者在感传过程中的皮层体觉区诱发电位(SEP)的特点。观察对象是10例感传稳定和清晰并能上达头面部的循经感传显著者和16例无感传的正常人。电刺激侠溪穴,同时引导刺激点对侧头皮的下肢,上肢、面部和同侧面部投射点的SEP,结果如下: (一)刺激感传显著者的侠溪穴除产生循经感传外,在对侧下肢投射点可记录到一个由P_1、N_1、P_2、N_2、P_3波组成的复合电位。峰潜伏期均值分别为45.1±4.63,57±5.71,72.9±7.34,84.8±11.1,106±10.4毫秒。由N_0-P_1,P_1-N_1,N_1-P_2,P_2-N_2,N_2-P_3组成的C_1、C_2、C_3、C_4、C_5成分的振幅的均值分别为0.47±0.19,0.87±0.47,0.98±781|0|0更新时间：2023-08-11
- 摘要：以往我们在摸索“经络感传”现象客观指标时曾以电脉冲刺激人体手、足、躯干及面部的个别腧穴而从被试者的头皮上记录平均诱发皮层电位。晚近早崎芳等做了刺激井、腧穴引起的体觉诱发电位的研究,但未报道面部腧穴刺激的诱发反应。本工作拟观察面部不同区域腧穴受有规律的电针刺激所诱发的皮层电位特征,以作为进一步探讨经络理论的基础。对象与方法被试者共43人(男26人、女17人),年龄22～64岁,平均39.3岁,共中5人系The present work was performed on 43 adults, aged 22～64 years. Fine needles made of stainless steel with diameter of 0.32 mm and length of 15 mm were used as stimulating electrodes and recording electrodes as well. The averaged evoked somatosensory cortical potentials were recorded from the scalp as electric pulses of 0.2 ms in duration and about 4 times sensa- tion threshold in strength were delivered with a frequency of once per se- cond for 128～400 times to the acupuncture points on the face. The early components of evoked response recorded from the contralateral "face area" on the scalp following stimulation of the acupuncture point Dicang, Jiache, Sibai or Yangbai consisted of several waves arranged in a W-shaped fashion. These waves were called - P_(20) - N_(30) - P_(40) - P_(55) using the nomencla- ture based upon peak polarity and latency. No significant differences between the latencies of the evoked potentials induced by the aforementioned acu- puncture points stimulation were noticed (P>0.1). However, the amplitu- des of the potentials following stimulation of Dicang and Jiache appeared to be larger than those of Sibai and Yangbai (P<0.025). The responses evoked by stimulating Renzhong were fundamentally similar to those by the Dicang stimulation in waveform except that 3 positive waves occurring in the early components in one case. In contrast to the Dicang, Jiache, Sibai or Yangbai stimulation which evoked responses on contralateral "face area" predominantly, the Renzhong stimulation evoked responses bilaterally on the scalp. As the evoked response from Dicang stimulation was compared with that from prior non-acupuncture stimulation, the N 30 peak latency of the former was 1.49 ms longer than that of the latter (P<0.025). No other significant differences between them were found935|0|0更新时间：2023-08-11
- 摘要：近年来的研究资料表明,中脑中央灰质是电刺激脑和吗啡、内啡肽脑内微量注射产生镇痛作用最有效的部位之一。中央灰质内阿片受体含量极为丰富。内啡肽含量很高,这些研究提示中央灰质可能在痛觉信息的整合中起重要的作用。我们前一工作曾表明,损毁大白鼠的一侧或两侧中脑中央灰质后,针刺镇痛效应明显降低,因而认为中脑中央灰质可能参与针刺镇痛过程,但是关于刺激中央灰质对针刺镇痛效应影响的观察,迄今未见报道。本文在于进一步阐明电刺激中央灰质的镇痛效应及其与针刺镇痛效应的相互关系。879|0|0更新时间：2023-08-11
- 摘要：据文献报道,脑刺激和吗啡镇痛均依赖于下行性5-羟色胺(5-HT)能通路的完整性。含有大量下行5-HT能神经元的中缝大核(NRM),正是这一通路的重要发源地。电针可激活NRM而镇痛,也能使中缝核区5-HT和它的主要代谢产物5-羟吲哚乙酸含量升高,NRM内5-HT能胞体荧光增强。减少中枢5-HT可相应减弱或消除电针镇痛效应[11～15]。那么电针激活NRM是否为5-HT能神经元机能活动的增强?为此,本工作在以往观察到电针对NRM神经元具有激活作用In our previous work most NRM neurons could be activated by electro- acupuncture (EA) and its effect could be partially blocked by iontopho- retic naloxone, suggesting that the activation of NRM may be mediated by endogenous opiate-like substance (OLS) released by EA. In the present study, according to the principle of the presynaptic negative feedback regulation the effect of iontophoretic 5-hydroxytryptamine (5-HT) on the neuronal activities in NRM was observed to further explore whether these activated neurons were serotonergic. The experiments were carried out on male adult rats under slight ure- thane anaesthesia. The unit activity was extracellularly recorded with the central tube of the multipipettes filled with 4 M NaCl. Most neurons in NRM (17 out of 27, 63%) responded to iontophoretic 5-HT with decreasing firing rate; only one neuron responded with increasing firing rate; and the remainder (9 of 27) had no change. Among 14 neurons activated by EA, 12 neurons were inhibited by ionto- phoretic 5-HT and all the neurons in which the nociceptive responses were inhibited by EA could be inhibited by iontophoretic 5-HT. Moreover, 7 out of 8 neurons in which the acupuncture inhibitory effect could be reversed by iontophoretic naloxone could also be inhibited by iontophoretic 5-HT. In addition, both 17 neurons inhibited by 5-HT and all 10 neurons which were antidromatically activated by the stimulation of dorsal lateral fascicular could be excited by noxious stimulation, classified as excitatory neurons. The above results suggested that most excitatory neurons activated by OLS released by EA might be considered as the serotonergic raphe-spinal neurons, which plays an important role in acupuncture analgesia.845|0|0更新时间：2023-08-11
- 摘要：循经感传路线形成的机理,存在着“中枢兴奋扩散”和“外周顺序激发”两种不同的设想。为了弄清这一问题,本文着重对最有代表性的足三阳经和任、督脉的感传路线进行了观察,并与体觉系统的分域定位关系进行了对比,结果如下: (一)对针刺胆经膝关节以下的侠溪、光明等穴位时感传能上达面部的30名受试者进行了400次观察,其中感传路线循经和基本循经的占83.5％。在同样的刺激条件下,感传路线基本上是稳定的,可以重复的。 (二)12名受试者,针刺分布在头面、躯干和下肢的相互远隔的胆经穴位时的789|61|0更新时间：2023-08-11
- 摘要：近年来的一些实验提示,尾核与痛觉及针刺镇痛作用有关。刺激尾核可以提高痛阈,可以加强电针效应,而损毁尾核可使电针效应有不同程度的减弱。对晚期癌肿引起恶痛用药物治疗效果不满意的病例,在尾核头部埋藏电极,刺激尾核,大部分病例可得到不同程度的镇痛效果。尾核内阿片样肽的含量很高,阿片样肽具有镇痛作用,这种作用可被纳洛酮部分阻断。无机离子在针刺镇痛中的作用,正逐渐被人们重视。根据目前的资料,尾核中的阿片样肽,主要是脑啡肽以及有关的六The quantities of opioid peptides, Cu(2+) and Zn(2+) and Zn(2+) were determined be- fore and after acupuncture in caudate nucleus perfusate. The cannula was sterotaxically implanted into caudate nucleus according to the atlas of Sawyer's (A_4, H_(4.5), L_3, or A_2, H_(3.5), L_3). The opioid peptides in the perfusate was purified through a column of Amberlite XAD-2 and deter- mined quantitatively by radioreceptorassay. Cu(2+) were determined be- fore and after acupuncture in caudate nucleus perfusate. The cannula was sterotaxically implanted into caudate nucleus according to the atlas of Sawyer's (A_4, H_(4.5), L_3, or A_2, H_(3.5), L_3). The opioid peptides in the perfusate was purified through a column of Amberlite XAD-2 and deter- mined quantitatively by radioreceptorassay. Cu(2+) and Zn(2+) and Zn(2+) were determined by anodic stripping voltammetry. It was found that the quantities of opioid peptides in the anterior portion (A_4 or A_5) were increased significantly about 10.98±2.38% (N=10, P<0.002) after acupuncture and the increment was parallel to the rise of pain threshold; while in the posterior portion (A_1 or A_2) there was no change. After acupuncture for 30 minutes, the quantity of Zn(2+) were determined by anodic stripping voltammetry. It was found that the quantities of opioid peptides in the anterior portion (A_4 or A_5) were increased significantly about 10.98±2.38% (N=10, P<0.002) after acupuncture and the increment was parallel to the rise of pain threshold; while in the posterior portion (A_1 or A_2) there was no change. After acupuncture for 30 minutes, the quantity of Zn(2+)was increased significantly about 0.17±0.06 μg/ml (N=10, P<0.02) and the increment was parallel to the rise of pain threshold. The quantity of Cu(2+)was increased significantly about 0.17±0.06 μg/ml (N=10, P<0.02) and the increment was parallel to the rise of pain threshold. The quantity of Cu(2+) was decre- ased significantly about 0.37±0.12 μg/ml (N=10, p<0.01). This shows that the analgesic effect of acupuncture is related to opioid peptides, Cu(2+) was decre- ased significantly about 0.37±0.12 μg/ml (N=10, p<0.01). This shows that the analgesic effect of acupuncture is related to opioid peptides, Cu(2+) and Zn(2+) and Zn(2+) in the anterior portion.869|0|0更新时间：2023-08-11
- 摘要：近年来不少工作证明中枢神经系统中的环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)在针刺镇痛中起着重要作用。例如大鼠侧脑室注射cAMP可明显拮抗电针镇痛和吗啡镇痛,射注cGMP可加强电针镇痛和吗啡镇痛。如果将微量的cGMP或其衍生物二丁酰cGMP(dbcGMP)注入大鼠缰核内,不但加强电针镇痛,并可延缓电针耐受的发展。但两种环核苷酸在脊髓中对针刺镇痛起何种作用,目前尚未见报道。本工作将二丁酰cAMP(dbcAMP)或二丁酰cGMP注入大鼠脊髓蛛网膜下腔内,观察其对电针镇痛的影响。914|0|0更新时间：2023-08-11
- 摘要：脑啡肽(EK)自1975年发现以来,不少研究已证明它参与镇痛作用,如当针刺镇痛时脑内及脑脊液中EK含量均升高。由于EK易被降解,因而在测定血浆内含量变化方面报道甚少。本文应用放射免疫法测定人体血浆中亮氨酸脑啡肽(LEK)样物质的含量,并试图探讨其与疼痛及镇痛的关系。对象与方法 (一)对象 1.正常人:11人均系本室健康的工作人员。男6人,女5人。年龄26～52岁。 2.病人:各种疼痛病人32例,男性32 patients with various pain perception, before and after acupuncture or operation, had been detected on plasma LEK. It revealed that: (1) the plasma LEK level (8:00-9:00) of patients with acute and severe pain were significantly lower than that of normal subjects. After relief of pain by either acupuncture or operation, the plasma LEK contents in mean value are increased significantly. (2) the plasma LEK level of patients with extration of nucleus pulposus were also lower than that of normal subjects, however, there were no obvious changes after acupuncture. (3) there were no any changes before and after acupuncture in normal subjects. This results suggested that plasma LEK might play an important role in the mechanism of pain perception and analgesia.720|0|0更新时间：2023-08-11
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