最新刊期
1988年第4期
- 摘要：微循环的观察研究已日益广泛地应用于临床各科,关于冠心病患者外周微循环的改变有一些报道,我们在观察针刺及穴位艾灸对冠心病患者球结膜微循环影响的基础上,进一步观察针刺对急性心肌梗塞患者球结膜微循环的影响,以探讨针刺治疗缺血性心脏病的机理。从1981年开始先后与北京市第四、第六医院协作,共观察急性心肌梗塞108例,现总结如下:It was reported previously that the dysfunction of microcirculation might occur in patients with ischemic heart disease and its extent correlated positively with the seriousness of disease. In order to study the mechanism of acupuncture for the treatment of ischemic heart disease,the effect of acupuncture on microcirculation of bulbar conjunctiva as observed in patients with acute myocardial infarction (AMI).Based upon the routine treatment,94 cases were equally divided into acupuncture group and ontrol group at random.In acupuncture group,patients were treated by cupuncture once daily,24 treatments in all.Before acupuncture and after 12 and 24 sessions,the patients' microcirculations were examined by microscopy and photography.The same procedure was performed in the control group. The immediate effects of acupuncture were investigated in 30 cases of the acupuncture group.An obvious dysfunction of microcirculation in bulbar conjunctiva was found in all patients with AMI.after the treatment,impronement of dysfunction of microcirculation manifested by the acceleration of blood flow,the increase of the diameter of micro-vessels,and the relaxation of the assembly of blood cells was observed. The results indicate that the function of microcirculation could be improved by acupuncture,which may contribute to the improvement of coronary circulation,and thus,may be helpful to the recovery of AMI patients.809|0|0更新时间：2023-08-11
- 摘要：我们以往工作证明,猫的十字沟前皮层参与对丘脑中央中核(CM)伤害性反应的下行性调节。本文比较了用利多卡因局部改变十字沟前皮层和 SI 区机能状态前后电针对 CM 神经元伤害性反应的影响,以探讨十字沟前皮层和 SI 区是否参与对 CM 核电针效应的下行性调节。实验用猫,硫贲妥钠麻醉下开颅,暴露右侧十字沟周围皮层,于同侧 CM 核上方颅骨钻孔。分离左侧(?)浅神经,以便施以伤害Extracellular recordings were made to investigate the influences of topical application of lidocaine at the preeruciate cortex and the primary somatosensory area(SI),respectively,on the inhibitory effect of electroacupuncture(EA)at“Huantiao”and“Zusanli”points on nociceptive responses of neurons in the nucleus centrum medianum (CM) in the cat.It was found that topical administration of lidocaine at either the precruciate cortex or the SI area suppressed the inhibitory effect of EA on nociceptive responses of CM neurons,whereas in the control group,administered with normal saline (N.S.) at either of the two cortical areas,EA produced remarkable inhibitory effect on the nociceptive responses.The difference was statistically significant between the two groups. Similarly,when the comparison of the EA effets induced on the background of lidocaine and N.S.application successively at either of the two cortical areas was made in same individual CM neurons,lidocaine application exhibited obvious suppresive action on the analgesic effect of EA.The suppression was stronger and more prolonged when lidocaine was applied at the precruciate cortex than at the SI area.The roles of the precruciate cortex and the SI area in descending regulation of EA effects in CM neurons were discussed.1112|0|0更新时间：2023-08-11
- 摘要：在针刺镇痛原理研究方面曾有报道认为:丘脑束旁核(Pf)为接受痛觉冲动的结构。其神经元的痛放电可被针刺穴位所抑制。而传导痛觉的 C 类纤维的传入信号,可在皮层引起潜伏期较长的诱发电反应。本实验室也观察到:用2%利多卡因局部阻滞皮层体感(?)区(S(?))或给予 r-氨基The present work was designed to investigate the effects of electroacupuncture(EA)on nociceptive responses in the nucleus parafascicularis (Pf) after topical administraction of GABA on the somatosensory area I (SI)and the precruciate cortex respectively by means of glass microelectrodes to record the activities of Pf neurons extracellalarly.The experiments were carried out on adult cats (2.0—3.5kg) immobilized with gallamine triethiadide. The results were as follows:When the functional state of SI was altered by topical application of GABA,there was no difference in nociceptive responses of Pf neurons before and after EA.However,in the control group with normal saline (NS) there was a significant difference in nociceptive responese before and after EA (P<0.05).Besides,the difference in the effects of EA between GABA+EA group and NS+EA group was statistically significant.Furthermore, using GABA administered on the precurciate cortex,The results were the same as those mentioned above. The data given above show that the SI area and the precruciate cortex are involved in descending modulation of EA effect in the nucleus Pf of the thalamus.1066|0|0更新时间：2023-08-11
- 摘要：过去,在痛觉和针刺镇痛的研究中,多以强电脉冲刺激传入神经模拟伤害性刺激,并以此引起的反应作为疼痛的指标。但强电刺激常引起多种神经纤维包括与痛觉无关的Aαβ纤维、传导“快痛”的 Aδ纤维以及传导慢痛的 C 类纤维同时兴奋。当多种神经纤维的传入冲动同时进入神经中枢时,又常常发生相互影响,往往是传导速度快的 A 类纤维传入抑制了传导较慢的 C 类纤维传入。因此,以前所用的痛反应指标不反映慢痛。923|0|0更新时间：2023-08-11
- 摘要：关于痛与镇痛问题的大量研究资料表明,在中枢神经系统中存在着内源性镇痛系统。位于低位脑干的中缝大核在该系统中处于十分重要的地位,它对脊髓水平接受的伤害性输入具有下行性调制作用。但是对该系统上行性作用则了解甚少。丘脑髓板内核群是伤害性信息整合的重要部位。形态学证明中缝核群有广泛的投射到The present work is an investigation of ascending effect of the nucleus raphe magnus and adjacent reticular formation on unit discharges of the nucleus centralis lateralis.Experiments were performed on fifty-nine curarized rabbits under artificial ventilation.The discharges of neurons in the nucleus centralis lateralis were recorded by glass microelectrode.The electrical stimulation(0.2ms,10-20Hz,100-300μA)of the nucleus raphe magnus and adjacent nucleus paragigantocellularis reticularis was given through bipolar concentric electrode.The results showed that;(1)The nociceptive discharges of pain- excitation neurons were modulated either by facilitatory (36/41) or by inhibitory(5/41) effect,after transection of dorsal half of spirral cord,similar effect could be observed:(2)The inhibitory effect on pain-inhibition neurons was released.The results suggest that there may be exist an ascending pain modulating action in thalamus from the nucleus raphe magnus and its adjacent reticular formation.668|0|0更新时间：2023-08-11
- 摘要：实验是在清醒和肌肉麻痹的家兔上进行,用同心园电极的单个或短串电脉冲刺激扣带回前部(32区),用玻璃微电极在丘脑束旁核(IF)中引导单位放电,为了阐明IF单位放电的增加和减少是与刺激脉冲同步出现的,故采用电子计算机处理的脉冲密度直方图来表明,其结果,在rF59个对痛刺激呈现兴奋反应的单位放电中,能对扣带回刺激呈现拉制效应的有38个,占64%,4个对痛刺激呈现抑制效应的PF单位,也能为刺激扣带回前部而增强抑制,占6.7%,同时还观察到在少数FF痛兴奋和痛抑制的单位放电中,刺激扣带回能增强其放电频率。这再次表明扣带回前部可以通过下行纤维的活动调制痛信息在丘脑水平的传递。772|0|0更新时间：2023-08-11
- 摘要：八肽胆囊收缩素(CCK-8)是一种典型的脑肠肽。在哺乳动物大脑皮层,丘脑和下丘脑某些区域内含有高浓度的 CCK-8。有人报道,将 CCK-8注入皮下大鼠对热板刺激的敏感程度下降,表明 CCK-8本身具有镇痛作用。也有人证明,给大鼠脊髓蛛网膜下腔和腹腔注射 CCK-8则The glass microelectrodes were introduced into nucleus parafascicularis(N.Pf)of thalamus in rats to record the discharges of pain-inhibition neurons(PIN) and pain-excitation neurons (PEN).The influences on discharges of PIN and PEN were observed after injection of chol(?)cystokinin octapeptide (CCK-8),morphine or morphine and CCK-8.The results showed that: 1.CCK-8 per se produced no significant influence on the electric activities of PIN and PEN in N.Pf. 2.Morphine resulted in an excitation of the evoked response of PIN as well as an inhibition of the evoked response of PEN. 3.CCK-8 could anlagonize the electric activities of PIN and PEN caused by morphine. The results suggest that CCK-8 per se has no the analgesia.But CCK-8 could antagonize the effect of morphine analgesia.953|0|0更新时间：2023-08-11
- 摘要：我们以前的研究发现,针刺镇痛时大鼠脑内去甲肾上腺素(NA)含量发生明显变化,而且它与针刺镇痛有密切的关系。许多研究资料也支持中枢 r-氨基丁酸(GABA)和乙酰胆碱(ACh)参与针刺镇痛过程。由于脑内各种神经介质在代谢和功能上存在密切的联系和动态平衡。在本工作中,我们观察了大鼠腹腔注射Sixty of rats were randomly divided into 6 groups:(1)Control;(2)Electroacupuncture(EA);(3)Bicuculline;(4)Bicuculline plus EA;(5)Atropine;(6)Atropine plus EA.The contents of noradrenaline (NA)in brain stem,diencephalon and telencephalon were determined by fluorcspectro-photometry.It was found that the pain threshold increased and the NA level in the telencephalon decreased markedly after EA.Bicuculline injection decreased the analgesic effect of EA by 77.7%,abolished the EA-induced decrease of NA content in the telencephalon and decreased the NA level in the brain stem after EA.Atropine decreased the analgesic effect of EA by 76.6% and decreased the NA contents in the brain stem and the dienc(?)phalon after EA.These results suggest that both GABA arid muscarinic c(?)olinergie receptors may play important roles in EA analgesia and this may be partially carried out through the brain NA system.941|0|0更新时间：2023-08-11
- 摘要：为了研究针刺镇痛过程中 ACh 和单胺类递质之间的关系,本文观察了电针镇痛过程中 ACh、5-HT、5-HIAA,含量的变化,又利用胆碱酯酶抑制剂(毒扁豆碱)和 ACh合成阻断剂(密胆碱)分别升高或降低脑内ACh 的方法观察电针对5-HT 代谢的影响。发现:针刺镇痛过程中5-HT 的代谢变化与ACh 有一定的关系。1008|0|0更新时间：2023-08-11
- 摘要：针刺具有调整功能的研究,文献报道甚多。针刺放应与脏器当时的活动水平有关,对血压、呼吸以及胃和膀胱等脏器的功能都有双向性影响。但有关针刺直接对中枢机能的调整作用,文献报道不多。本实验的目的是应用强、弱两种电刺激怒叫中枢引起叫反应,以叫反应的潜伏期和声强作为指标来观察电针对怒叫中枢是否具有调整作用。776|0|0更新时间：2023-08-11
- 摘要：电针对机体多种生理功能具有调整作用。但对在生理功能调节中起重要作用的神经内分泌系统的影响,报告较少。本室曾报告电针"肢中"穴可刺激授乳期大鼠催乳素分泌。本文进一步观察到电针"脸中"穴可使非授乳大鼠(雄鼠,动情间期雌鼠及去卵巢补雌激素鼠)催乳素分泌增加,更证明电针可影响神经内分泌系统功能。另外,在一种动物模型身上针刺三种不同穴位(足三里、足临泣、植中)均引起血浆催乳素升高。因此不能排除其中有应激反应的成分。但"值中"穴的效应最显著,与另外二穴比较存在着量的签别。尤其在穴位组合实验中,针刺"足临泣"穴可拮抗针"值中"穴的效应。这些结果均显示一J'穴位的相对特异效应。本文结果对进一步阐明针灸催乳机理及用针灸治疗高催乳素血症的可能性有所启示。743|0|0更新时间：2023-08-11
- 摘要：心内膜下心肌缺血是目前医学界研究较活跃的问题之一。因心内膜下缺血往往涉及范围广泛,且易引起电不稳定,若治疗不当,其远期预后与穿壁型心肌梗塞者相同。但内膜下心肌梗塞往往在梗塞区内含有较多的存活心肌,因此,若处理及时,可望较好的恢复。临床上早就认识到中枢神经功能紊乱,能引起内膜下心肌缺血或梗塞,但其机理尚不清楚,一般认为,心电图 S-T段下移代表内膜下心肌缺血,但缺乏直接根据。Hoffman 和 buckberg 用标记有放射Thirty-two rabbits were anaesthetized with mixture of α-chloralose and urethane and ventilated with a volume controlled respirator.After midsternal thoractomy the heat was suspended in an open pericardical cradle.Left ventricular (LV) pressure was recorded through a fluid-filled catheter inserted into the left ventricle through LV apex.Aortic pressure was recorded through a fluid-filled catheter introduced into the ascending aorta through left carotid artery.Each catheter was connected to a blood pressure tranducer Pso.The epicardial electrocardiogram (EECG) was measured by a cotton wick—normal saline electrode.The LV and aortic pressure as well as EECG were recorded simultaneously on a polygraph RM-6000 at a paper speed of 100mm/sec. The diastolic pressure time index (DPTI)/tension time index (TTI) ratio and EECG S-T Segment changes were taken as the indices of LY transmural blood flow.DPTI/TTI and EECG S-T segment markedly depressed (P<0.01) during stimulation of dorsal median hypothalamus (DMH) with a pair of concentric electrode,with persisted at least 60 minutes after stopped stimulation of DMH.And this effect can be relived by synchronous stimulation of MN (P>0.05). This study indicated that DMH takes an important role in both inducing subendomyocardial ischemia and reliving subendomyocardial ischemia through stimulation of MN.852|0|0更新时间：2023-08-11
- 摘要：临床上针刺具有调整脾胃功能,治疗胃肠疾患的疗效。有关实验工作除了早期有针刺影响胃运动和胃液分泌的报道之外,近年来针刺影响胃电活动的报道较多。然而胃血流和胃液分泌紧密相关,并在胃疾病的发生机理方面起着重要作用。针刺对胃血流的影响如何,至今未见报道。本工作研究针刺对胃血流的影响及其神经机制,并就电针和手针对胃血流的影响,相应的胃液分泌及胃电变化进行了分析比较。864|0|0更新时间：2023-08-11
- 摘要：针刺次髎穴能治疗盆腔疾患已确切无疑,而针刺次髎穴复合麻醉用于全子宫切除及剖腹产等手术却是近几年才开始的。目前临床上积累了大量资料,而就其机理问题仍旧无法解释,我们用辣根过氧化物酶(HRP)法对次髎穴与子宫的传入神经分布进行了研究,发现二者之间有9个节段的重叠(L_2—S_4),并对其可能的镇痛原理进行了分析。本文企图以宫内压为指标观察电针对子宫活动的影响及分析其产生针效的可能途径。769|0|0更新时间：2023-08-11
- 摘要：“子午流注”针灸疗法是中医颇具特色的治疗手段,临床实践表明疗效较好。用现代时辰生物学方法对这一独特疗法加以深入研究是有重要意义的。在许多细胞的生理活动中,cAMP,cGMP 是重要的第二信使,二者在细胞内的含量及其比例与细胞的功能状态有密切关系。已有文献报道人血浆 cAMP 水平存在近日节律性变化;另有报道表明血浆96 healthy male Wistar rats were housed in a light-controlled room for over 10 days prior to the experiment.Lights were on between 8:00 and 20:00 each day.Food and water were ad arbilrium.The animals were divided into acupuncture group and control group.Experimental times were 5:00,11:00, 17:00 and 23:00.After acupuncture at bilateral Huantiao points for 30 minutes the animals were decapitated immediatly for plasma cAMP and cGMP radio- immunoassay.The results showed.1.The plasma level of cAMP presented a diurnal variation which peaked at 17:00 and (?)ouched the bottom at 23:00 Acupuncture increases the concentrations of cAMP in all four times of the day but did not alter its diurnal pattern.2.There was no significant difference among the plasma cGMP levels at the four limes of the day.Acupuncture could increase the cGMP levels at 5:00,17:00 and 23:00 while not at 11:00, this suggests that the effects of acupuncture on plasma cGMP level are different at different times of the day.951|0|0更新时间：2023-08-11
- 摘要：针刺对慢性炎症局部的镇痛作用,已为大量的临床和实验观察所证明。我们也以佐剂性关节炎大鼠的炎症性疼痛为模型,证实了针刺对炎症局部具有明显的镇痛效果。针后,实验动物的中枢神经系统组织内的脑啡肽含量明显增加,说明针刺可能是通过提高体内的内源性吗啡样物质(MLS)含量,兴奋相应的受体而发生镇痛作用的。但针刺与某些兴奋吗啡样受体的镇痛药物不同,它可能是一种多元性自我调节的过程,除提高Sixty seven rats,weighting from 150 to 200g,were divided into 5 groups:blank control (?)roup,arthritic group,arthritic with acupuncture group,fentanyl+droperidol (FD) group and FD with acupuncture group.Except the normal control all the rats were administcred with complete Freund's adjuvant,then arthritis occurred.The arthritic rats in the acupuneture group were given by electro-acupuncture at“Huantiao”points bilaterally lasting 20 minutes every days for 5 days.After the last stimulation of needling,they were blooded. In the FD group,fentanyl 10μg/kg and dropevidol 0.5mg/kg were given to each rat.15 minutes later,they were tested and cAMP content of plasma were determined by radioimmunoassay method.Results showed that the content of cAMP was at 56.4±14.4pmol/ml in the normal control and 47.3±15.4pmol/ml in the arthritic group.There was no significant difference between these two groups statistically.But it was as higher as 124.4±57pmol/ml of cAMP in the acupuncture group.A comparison was made among these groups (p<0.001).Another series study showed that no any obvious change of the cAMP content could be found in the FD group.The level of cAMP increased markedly in the FD with acupuncture group (P<0.001).Data obtained from our experiment showes that not only pain threshold of the animals but also the content of cAMP in the plasma increased after needling.The fentanyl and droperidol can increase the pain threshold obviously,but there is no influence on the level of cAMP.If FD combines with acupuncture application,the cAMP content still rise after needling.The results above mentioned suggests that cAMP could play an important role in the pain sensory regulation by acupuncture.1082|0|0更新时间：2023-08-11
- 摘要：针刺人中穴具有回阳救逆之功效,其历史已有几千年,然而对其作用机理的研究,仅从五十年代末期开始,因此有许多问题需要探讨。以往的生理研究认为,动物心脏功能的改善在针刺“人中”抗休克过程中起重要作用。但这种作用的物质基础是什么,目前尚未见到组织形态学方面的报导。本文试图在家兔失血性休克的病理基础上,给予针刺“人中”治疗,来观察心肌糖原和磷酸化酶的变化,为针刺抗休克的基础研究提供组织化学的实验依据。766|0|0更新时间：2023-08-11
- 摘要：医学上对瘫痪病人的治疗效果还不能令人满意,提高瘫痪病人的治愈率是人们关心的问题。众所周知,针刺对人体的作用有多方面,而针刺在临床的应用也很广泛,多年来临床治疗瘫痪病人常合并使用针刺,但效果不一致,故难于肯定针刺对神经再生的作用,而这方面的实验研究工作也缺乏,为此几年来我们进行这方面的研究工作,在观察We studied effect of acupuncture on regeneration of rat's radial nerve.After the right radial nerves were severed,rats were reared for 7.10 or 14 days.In this period,we gave acupuncture therapy to the acupunctured.The regenerations of radial nerves were examined by the retrograde transport method of HRP.The principal result was as follows:14 days after the right radial nerves were severed,the more regenerated fibers can be found in the right radial nerves of the majority of the acupunctured as compared with those of the match controls.It is significant statistically(P<0.05).It was shown that acupuncture promoted the regeneration of rat's radial nerve.We have found that acupunctupe promote regeneration of rat's hypoglossal nerve.It was sure that acupuncture promoted the regeneration of rat's peripheral nerve.749|0|0更新时间：2023-08-11
- 摘要：人和恒温动物的体温,在下丘脑体温调节中枢的控制下,维持在一个稳定的水平。但在疾病的情况下,这种稳定被打破,则出现发热。发热是许多疾病的主要临床表现之一,是一种基本病理过程,其发生发展机理有不少问题已有研究。而针刺疗法对许多发热性疾病又有显著疗效。本文综合有关文献和我们近年来的主要工作,将针刺对体温的调整作用及其机理作以简述。722|0|0更新时间：2023-08-11
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