最新刊期
1990年第2期
- 摘要：臀位对围产儿影响较大,如早产、脐带脱垂,后出胎头困难等,据文献报导,臀位产围产儿死亡率比头位高3～10倍,近年来虽然放宽了臀位剖腹产指征,死亡率已下Applying fresh ginger paste at Zhihying acupoint before retiring, we treated 133 pregnant women (28 to 38 weeks' gestation) with breech position. There were 118 primigravidas. 238 untreated paegnant women (28 to 32 weeks' gestation) with breech position made up the control group. 113 out of the treated pregnant women had normal fetal position after treatment with 77.4% of correction rate. 48 out of the 113 pregnant women whose fetal position corrected by treatment only received once therapy, accounting for 42.5% of cured cases. Spontaneous correction of fetal position happened in 123 pregnant women of the control group with 51.6% of correction rate. There was a significant difference in the correction rate between study and control groups. (P<0.01), suggesting that this therapy is easy, economical, safe, and suitable to populaization at the basic level.641|0|0更新时间：2023-08-11
- 摘要：颅脑外科手术由于手术时间较长,手术难度较大,通常在全身麻醉气管内插管下进行。自从1965年针刺麻醉应用于颅脑手术,尤其用于前颅凹手术,因其效果好、安全简便、病人乐意接受,因而得到了普遍推广应The paper reports 174 cases of brain operations in temporo-fronto-occipital region by using the regime of combined acupuncture and medication. The patients comprised of 122 males and 52 females. The acupoints consisted of ear needling and body needling. Adjuvant drugs used were half-dosage Innovar and 0.1% lidocaine for scalp infiltration. According to the documented two-grade scaling criteria, 97.1% patients belonged to grade I. No obvious discrepancy existed between ear needling group and body needling one. Three controlled groups are presented for comparison: 1) 0.1% lidocaine alone; 2) acupuncture plus normal saline; 3) acupuncture plus 0.1% lidocaine. The resultant P value was less than 0.005, with remarkable statistical significance. It is revealed that 0.1% lidocaine per se cannot achieve satisfactory analgesia, whereas the efficacy of acupuncture can be greatly enhanced by the combination of 0.1% lidocaine and acupuncture. This method is proved as an effectual means to offset the incomplete analgesia of acupuncture, especially for those requiring intraoperative demonstration of surgical effects, to avoid impairment to functional areas of cerebral cortex, which are undoubtedly superior to general anesthesia.714|0|4更新时间：2023-08-11
- 摘要：强啡肽(Dynorphin)是1979年Goldstain等发现的一种内源性阿片肽,它在离体豚鼠回肠标本上具有强烈的阿片样活性。近年来,对于它在体内不同中枢部位的痛觉调制作用以及在电针镇痛中所起的作用日益引起人们的兴趣。在脊髓内,已有资Previous studies have shown that 2Hz but not lOOHz eiectroacupuncture (EA) stimulation released β-endorphin in PAG of the rat to induce analgesia. The present study was underlaken to see whether dynorphin plays a rle in PAG in mediating analgesia induced by low and high frequency EA. Injection of affinity purified dynorphin antibody (1:350,000 in RIA titer) 1μl into PAG blocked 2Hz EA analgesia almost completely, and 15Hz EA analgesia partly, leaving 100Hz EA analgesia intact. This blocking effect was totally disappeared when the antibody was diluted to 1/10 of its original concentration (1:35,000).Besides, injection of dynorphin into PAG through chronically implanted cannula showed no analgesic effect. The results suggest that the blockade of 2Hz EA analgesia by high titer drnorphin antibody injected into PAG may have been the result of cross reactivity of the antibody to other opioid peptides (such as β-endorphin, enkephalin, etc) released in the PAG area. The data also stress the importance of using antibodies of proper titer and concentration to exclude false positile or false negative conclusions in adopting the antibody microinjection techniques, as was repeatedly shown in the immunohistochemical studies.968|0|2更新时间：2023-08-11
- 摘要：P物质(SP)在痛觉感受方面已有不少研究。多数学者认为,在脊髓水平它是传递痛信息的神经递质;而在中脑导水管周围灰质(PAG)或脑室注射SP则出现镇痛作用。因此,人们考虑到脑内SP是否参In order to understand the role of substance P (SP) in the brain and the relationship between SP and enkephalins in the electroacupuncture analgesia (EA), we have observed the influence of SP-antagonist, (D-Arg', D-Phe5, D-Trp5, D-Trp(7.9), Leu(7.9), Leu(11))-SP (DADPDTL) injected intracerebroventricularly (icv) on EA and the change of the level of SP in the brain regions of the rat durinf EA. We have made a further observations on the influences of the naloxone (NX) on the che change of the content of SP induced by EA and DADPDTL on the increase in Leu-enkephalins (LEK) induced by EA. The Wistar rats were used in the experiment. The latency of the tail flick, immersing the tip of rat tail (4cm) into hot-water of 50℃, was taken as the pain threshold. The drugs were injected icv via plastic cannulae implanted in the bilateral ventricles. The EA was applied to the point of "Zusanli" (S36). The contents of SP and LEK were determined radioimmunoassay in the hypothalamus, mid-brain, striatum and pons-meduila-oblongata. The pain threshold was increased by 48±9% (P<0.01) after EA. But icv injection of DADPDTL decreased the pain threshold by 14±7% after EA. The result suggests that DADPDTL can antagonize the effect of EA and that SP in the brain is involved in EA. After EA the contents of SP in the hypothalamus and mid-brain of the rats were decreased by 29% and 28% in comparison with that of the control group respectively (both of them, P<0.05), but the contents of SP in the striatum and pons-medulla-oblongata had no significant change. It indicates that EA can decrease the levels of SP in the hypothalamus and mid-brain of rats. In NX (20ug) injected icv plus EA group, the effect of EA might be blocked partially (the pain threshold increased only by 20±12% after EA, P>0.05), while the levels of SP in the hypothalamus and mid-brain were higher than simple EA group, but not different to that of control group. The result shows that NX administered icv can inhibit the decrease of SP in the brain induced by EA. While DADPDTL blocked the effect of EA, the levels of LEK in the hypothalamus and mid-brain did not have significant difference with that of simple EA group, but it was higher than that of control group. The result shows that DADPDTL cannot change the increase on LEK in the brain induced by EA. As mentioned above, endogenous SP in the brain is involved in the EA. The relationship system is first activated by EA and in turn, the enkephalin accelerates the release of SP to be involved in analgesia.887|0|1更新时间：2023-08-11
- 摘要：P物质是伤害性刺激一级传入的神经递质。我组以前的实验证明,电针镇痛的大鼠低位脑干与腰髓的P物质含量增加。当大鼠脑池注射5.7-双羟色胺一周后再给电针,电针镇痛作用被去除,此时脑干和P-Chlorophenylalanine (PCPA) 250mg/kg IP. was given to a group of rats. 72 hrs later the electro-acupuncture analgesia was tested and substance P (SP) in the brain stem and the lumbar spinal of the rats was determined by RIA. After PCPA injecting the electro-acupuncture no longer caused analgesia but lowered the pain threshold. Meanwhile the level of SP in the brain stem and lumbar spinal did not inereased but much lowerd than the group of vihicle injection combined with electro-acupuncture. It suggests that by PCPA depleting the 5-HT in CNS and abating the 5-HT-energic descending inhibition the electroacupuncture no longer causes analgesia but promotes the SP transmitted release. It further suggests that in lower brain stem and spinal transmission of SP was regulated by descending inhibition. Analgesia of electro-acupuncture activates the 5-HT-energic descending inhibition and decreases the nociceptive transmission of SP partly.986|0|2更新时间：2023-08-11
- 摘要：我们曾报道,脑室注射促甲状腺素释放激素(TRH)能对抗电针(EA)和吗啡的镇痛效应,,其机理不清楚。有资料表明,TRH对抗戊巴比妥的镇痛作用是通过影响神经细胞内cAMP实现的,脑内注入Experiments wese performed on 42 female albino rats weighing from 180-250gm. The pain threshold (PT) was determined by radiant heat induced tailflick method. The cAMP contents in various regions of brain were measured by radio-immunoassay. Electro-aeupuncture (EA) at bilateral "Zusanli" and "Sanyinjian" in rats significantly elevated PT, increased the content of cAMP in the hypophysis, while decreased that of septal nucleus. No effects were found in the basal PT and the cAMP contents of the hypophysis and septal nuclei after intraventricular injection of TRH, After TRH administered intraventricularly, however, EA didn't elevate PT, but still increased hypophysial cAMP with a dereasc in the level of cAMP in the septal nucleus. These results suggest that the cAMP may be related to analgesic effect induced by EA in some brain regions, and TRH injected into cerebral ventricles can antagonize the analgesic effect caused by EA, but this effect seemed to have nn relation to the conents to the contents of cAMP of hypophysis, septal nucleus, caudatum, hypothalamus and thalamus.843|0|0更新时间：2023-08-11
- 摘要：已有文献报道视前区是脑内与镇痛和针刺镇痛有关的核团之一。我们曾观察到视前区注入6-羟基多巴胺,减少内源性儿茶酚胺含量可以加强针刺镇痛作用,提示视前区内丰富的儿茶酚胺神经递质可能参与针Previous work has shown that activation of catecholamine in the preoptic area is to the disadvantage of acupuncture analgesia. In this work microinjection and push-pull perfusion as well as HPLC-ECD were used to observe the effect of noradrenaline and dopamine in this area on acupuncture analgesia. The results indicated that microinjection of noradrenaline (0.5μg/unilateral) into the preoptic area could attenuate acupuncture analgesia, while dopamine (2μg/unilateral) had no effect on acupuncture analgesia. During acupuncture analgesia, the contents of noradrenaline and MHPG in the perfusate from the preoptic area were markedly decreased, and that of dopamine, however, was not changed significantly. The above results suggest that activating noradrenaline, but not dopamine, exerts antagonistic effect on acupuncture analgesia.1010|0|3更新时间：2023-08-11
- 摘要：组胺H_1受体拮抗剂异丙嗪(Promethazine),即非那根(phenargan),是临床上常用的药物。在临床针刺麻醉中,普遍用为针麻的辅助药物,主要目的是镇静镇痛。但其确切的作用效果及其作用机制却未见研究报道。通过多年的研究,观察临Promethazine, one of histaminergic Hi-receptor antagonist, was often used as an adjuvant drug prior to and during acupuncture anesthesia in clinics, how- ever, its effects was not known clearly. By using potassium iontophoretic dolorimetry and stimulating unilateral "Hegu" and "Waiguan" points with electroacupuncture (EA) in 42 rabbits, we found that Promethazine could drop the pain threshold in small dosages (0.5mg/kg, lmg/kg) and raise the pain threshold in relatively large dosages (2mg/kg, 4mg/kg). In different dosages (1mg/kg, 2mg/kg), promethazine could attenuate the analgesic effect of EA. It was suggested that promethazine should beused carefully in acupuncture anaesthesia.963|0|0更新时间：2023-08-11
- 摘要：脑波的性质非常大的程度取决于大脑皮层的活动程度,脑电活动情况常作为脑皮层机能状态的一个指标。已有研究用脑电图作为客观指标来量度由电刺激牙齿引起的疼痛以估价镇痛的程度。随着计算机在生物医The present study was to observe the change of EEG power spectrum during acupuncturing, nonpain stimulating and pain stimulating; then to comparatively analyse the effects of acupuncturing acupoint on brain function. The work was performed on 3o normal subjects. Nonpain or pain stimulation was applied to a medial finger, and the intensity of stimulation was determined by subject's report. Acupoints were "Neiguan" and "Jianshi". EEGs were recorded on a tape recorder before, during and after each stimulation. Then EEG power spectrum were analysed by SM-2100 computer. The results were as follows: According to the analysis of EEG power spectrum, in most of subjects, alpha (a) band was shifted to higher band during pain stimulating, there was significant change, P<0.05. The highness of n spike was significantly increased during acupuncturing acupoints, P<0.02. ' The ratio of 5 power spectra to theta (9) and delta (δ) power spectra showed increase tendency during acupuncturing or nonpain stimulating, but decreased during pain stimulating. It was indicated that nociceptive pain-stimulation resulted in hyposynchrony of EEG. frequency was increased, amplitude was decreased, a rhythm was inhibited to a certain extent; acupuncturing acupoints had the effect which could strengthen the stability of EEG rhythmic ' activities. We know that EEG rhythmic activities show clearly the stability of balance insidje orpanism. So this result suggested that acupuncturing acupoint could play a role in modulating the balance inside organism and enhancing the stability of brain function.994|0|1更新时间：2023-08-11
- 摘要：一般认为,伤害性刺激的一级传入纤维主要为含P物质(SP)的C类纤维,其胞体是脊神经节内的B型细胞。关于C类纤维在电针信息传入中的作用,至今仍存在争议。众多资料表明,辣椒素对脊神经The present paper is designed to investigate the variation of pain threshold and electroacupuncture analgesia of rat, and to observe the immunohistochemical changes in spinal ganglion and dorsal horn of lumber and sacral segment of spinal cord after extradural administration of capsaicin (100μg/rat). It was found: 1. Obvious decrease of pain threshold 60 mins after injection of capsaicin, and the pain threshold restored nearly to the level of pre-treatment at 90 mins of post-treatment of capsaicin. 2. Apparent elevation of pain threshold on 1st-15th day after injection of capsaicin. 3. The efficiency of electroacupuncture analgesia 7th day after injection of capsaicin was obviously weaker than that of pre-treatment of drug and that of solvents treatment in the animals of control group. 4. The SP-LI, ENK-LI and FRAP were all weakened in dorsal horn of spinal cord 1h after capsaicin treatment. However, on the 7th day, with the exception of decrease of SP-LI and FRAP, the ENK-LI in dorsal horn was strengthened and the activity of FRAP in spinalganglionic cells of B type disappeared. The foregoing results indicated that the metabolism and function of C fibers of primary afferent especially the SP containing nerve and those of ENK-containing neurons could be influenced by the extradural injection of capsaicin. And the primary afferent C fiber (inclunding the SP containing nerve) may play important roles in the imput of the informations of pain, and needling, as well as in the acupuncture analgesia.1007|0|3更新时间：2023-08-11
- 摘要：为了探讨外周乙酰胆碱(ACh)与针刺穴位引起感觉信息一级传入的关系,本文用不能通过血脑屏障的胆碱酯酶抑制剂(新斯的明)和乙酰胆碱合成阻断剂(密胆碱)及乙酰胆碱外周给药,以升高或降低外周乙酰胆碱In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor-Neostigmine and the ACh synthesis blocker-Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats. The results indicated that: 1) The effect of electroacupuncture analgesia can be enhenced by subcutaneous injection of neostigmine which related to the dosage used. 2) The influence of electroacupuncture analgesia can be markedly inhibited by intraperitonal injection of Hemicholine. 3) This influence of suppression by Hemicholine can be reversed at once when acetylcholine in combination with neostigmine was injected. But could not reverse by neostigminealone. It suggested that the effect of electroacupuncture analgesia and the primary input of acupuncture sensation were significantly related to the level and content of ACh in periphery.868|0|2更新时间：2023-08-11
- 摘要：在休克的发生发展过程中血管紧张素等一些体液因素起着重要的调节作用。但心钠素(ANP)——一种重要的循环激素在休克中的变化和意义目前尚不明确。为此,本In this work, we measured the changes of atrial natrinretic polypeptide, (ANP) and angiotensin (A_Ⅱ) in plasma of normal and hemorrhagic shock rabbits by the radioimmunoassay (PIA). Meanwhile, we observed the effect of acupuncture on the changes of ANP and A_Ⅱ in plasma of hemorrhagic shock rabbits. The results showed that the contents of ANP and A_Ⅱ in plasma increased when the hemorrhagic shock extended" Acupunctured at "Neiguan" can antishock by increasing blood pressure and can decrease the ANP and A_Ⅱ in plasma. Shock may promote the secretion and reduce the disintegration of ANP. Acupuncture can anti-shock by increasing blood pressure and correcting the disturbance of secretion and metabolism of ANP and A_Ⅱ during shock.812|0|2更新时间：2023-08-11
- 摘要：中枢神经系统的兴奋传递主要依靠各种神经递质,而神经递质与细胞膜上相应的受体作用时又必然有离子参与。因此在分子水平上研究痛觉机理和痛觉调整,离子的作用占有重要位置。我们对手术病人针刺Forty patients treated by thyroidectomy received superficial cervical plexus block or electric acupuncture stimulation of acupoint Hegu and Neiguan bilaterally. All patients were random divided into groups of C, A_1, A_2 and A_3 on the basis of anesthetic method. Every patients were measured their serum concentration of Na+, K+, K+, Ca+, Ca(++), Cu(++), Cu(++), Mg++ and Zn(++), Mg++ and Zn(++) before and during anesthesia or electric acupuncture stimulation and postoperation. There was no difference about analgesic effect of four groups (P>0.05). Serum Ca(++) before and during anesthesia or electric acupuncture stimulation and postoperation. There was no difference about analgesic effect of four groups (P>0.05). Serum Ca(++) concentration reduced various level during electric acupuncture stimulation (P<0.05-0.01), but no difference between group A_1 and group A_2 (P>0.05). The results showed: 1. It made level of serum Ca(++) concentration reduced various level during electric acupuncture stimulation (P<0.05-0.01), but no difference between group A_1 and group A_2 (P>0.05). The results showed: 1. It made level of serum Ca(++) reduced because internal environment of patients were affected by the signal of acupuncture. 2, There was no addition effect for the influence of serum Ca++ when electric acupuncture stimulated points Hegu and Neiguan at the same time intravenous injected Pethedine (1.3mg/kg). 3. It probably disturbed the value of serum Ca(++) reduced because internal environment of patients were affected by the signal of acupuncture. 2, There was no addition effect for the influence of serum Ca++ when electric acupuncture stimulated points Hegu and Neiguan at the same time intravenous injected Pethedine (1.3mg/kg). 3. It probably disturbed the value of serum Ca(++) concentration when intravenous injected 5% Glucose during the operation, but it had not influence on analgesic effect. 4. Acupuncture probably made concentratration of serum Na(++) concentration when intravenous injected 5% Glucose during the operation, but it had not influence on analgesic effect. 4. Acupuncture probably made concentratration of serum Na+, Cu+, Cu(++), Mg(++), Mg(++) and Zn(++) and Zn(++) changed which had statistical difference but with marked irregular figure, the real causes are worth going further into research in future.922|0|0更新时间：2023-08-11
- 摘要：人中穴作为重要的抢救穴,已为临床实践所肯定,其作用效果也为许多实验研究所证实。我室以前的工作已经证实,刺激兔人中穴区对实验性呼吸暂停动物具有明显的始动效应,对正常动物亦有使呼吸加强的It had been reported that the stimulation of the "Renzhong" starts respiratory activity in rabbits whose respiration has been suspended. This action was caused by stimulating "Renzhong. Those signals transmit to the nucleus of trigeminal spinal, and go to influence the nucleus of respiration. Those signals include of pain and other sense. This study investigated whether this stimulation of "Renzhong" is caused by pain or another stimulus. Phrenic nerve discharges and respiratory rates of 7 anesthetized rabbits, each weighing 1.5 to 2.0 kg were recorded. Stimulation of the "Renzhong" by electrical impulses (10 ms pulse,20 Hz, 0.4 - 4mA,duration 3-5 secends). Results. 1. Stimulating the "Renzhong", resolted in an 83±16% increase in the amplitude of phrenic nerve discharges, and a 31±6% decrease in respiratory rate. 2. morphine was then injected into the rabbits (5mg/kg). After 8 minutes, the amplitude of phrenic nerve discharges had decreased by 22±9% and the respiratory rate had decreased by 16±6%. 3. At this acupoint, stimulation of the "Renzhong" resulted in a 43±8% increase of the amplitude of phrenic nerve discharges and a 20±6% decrease in respiratory rate. These results suggest that in the effect of the stimulation of "Renzhong" on the respiration pain sensation is one factor among the rest.760|0|0更新时间：2023-08-11
- 摘要：胃节律紊乱,系胃功能性疾病。它的出现可能是胃肠道疾病的早期表现,也可能是胃肠道以外某些全身性疾病通过神经或体液因素在胃部的反应。据文献报道,用药物引起的胃节律紊乱类似自发性的胃节律紊In fasting and anaesthetic rabbits, the experimental model of gastric dysrhythmia could be produced by electric stimulation of inferior phrenicus vagus and splanchnic nerve for innervation of courpus and antrum, or by left gastric artery infusion of Adr, Ach and glucacon at a steady vilocity. The results were as follows. (1) Electrical stimulation of inferior phrenicus vagus at low frequency and intensity could increase the frequency and amplitude of basic electric rhythmia (BER) or slow wave (P<0.01), and might induced tachygastria and tachyarrthythmia. Electrical stimulation of splanchnic nerve could increase the frequency and amplitude of BER (P<0.05), and might induced bradygastria. (2) Bradygastria cculd be elicited by left gastric artery infusion of Adr (400μg/kg/h). The frequency and amplitude of BER induced were decreased" Tachyarrhytmia could be elicited by infusion of Ach (400μg/kg/h). The frequency and amplitude of BER induced were increased. Dysrhythmia of BER could be elicited by infusion of glucagon (400μg/kg/h). (3) Electroacupuncture of "Zusanli" acupoint may exhibit double modulated effects on experimental model of gastric dysrhythmia. Different types of gastric dysrhythmia including tachygastria, bradygastria and tacbyarrhy thmia could turned to approach the normal gastric myoelectric activity. It is revealed that such effects of electroacupuncture may be mediated via autonomic nerve and peripheric special receptors.909|0|2更新时间：2023-08-11
- 摘要：以往工作表明,人和大鼠的经脉循行线都有高度敏感、低阻抗和高音特性,而且都有严格的定位。形态学方面发现,这条线下神经束、神经末稍的分布显著多于非低阻区。而且,大鼠经络低阻点下肥大Observation of the number, distribution and characteristics of the mast cells under the low impedance acupuncture meridian lines of 19 amputated limbs of patients suffered from osteoblastoma and 21 rats was carried out microscopically afted sectioned and toluidine blue stained. Resulls revealed that the number of the mast cell was more concentrate under the meridian lines in comparison with their control areas. The difference was significant. This experiment reflexed another aspect of the morphological basis of the biophysical nature of the acupuncture meridian.879|0|10更新时间：2023-08-11
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