摘要:在长期的临床实践中发现老年人的针麻拔牙效果普遍较好,为了验证这一问题,笔者等将1973~1988年间较完整的4,000余例针麻拔牙资料中的老年人(60岁及以上者)825例次(以下简称甲组)单独统计,并任It has been found that the effects of tooth extraction under acupuncture anesthesin (AA)for the old patients are generally quite good. In order to verify this result, the authors had statistically analysed 825 cases aged over 60 years (Group A) and equal quantity whose age were between 18—40 years old (Group B) out of morethan 4000 cases whose records of AA were rather completely during 1973 to 1988. 1. There was no sifnficant difference under AA for different sexes. 2. The differences of the excellent rate of AA between Group A and Group B were extremely evident either in the positions of the tooth or the reason of tooth extraction. The former was 89.04% and the latter 76.20% (P<0.005). 3. Although a low rate in excellence of tooth extraction under simple AA (only 75.58%), not so good as the effect by AAA (an average about 88.21%), the simple AA was more common and more easier to be accepted by patients. 4. Tooth extraction under AA has been proved to be safe, effective and without any complications. 5. The reasons for senior to extract their teeth were almost for the broken crowns and of roots or the purposes of prosthetic restoration. Even though the pain thresholds in the senior were commonly higher. It is still an important factor of the good effect and good rate of tooth extraction under AAi Refering to the statistic in this stady the authers suggest that the hospitals which can ues the AA for tooth extraction adopt the method as the first choice of anesthesic method to the senior who intends to accept it.
摘要:火罐疗法施于内科疾病,尤其是治疗心血管系统疾病,过去不多见。今试以用于改善心脏供血和纠正心律失常,经初步观察10例。从心电图可见,火罐疗法有改善心脏供血和纠正心律失常明显改善的作用,现报导如下:Cupping is one of the non-Pharmacotherapy without pain and side-effect. Btt it was varely used in angiocardiopathy previously. However, if was found that cupping has good resulk in treating angiocardiopathy with 10 cases observed recently. After treatment, the symptoms of the patients have been alleviated or subsidect and the ELG have been inproved obviously.
摘要:中脑中央灰质(导水管周围灰质,简称PAG)存在防御反应中枢,刺激PAG尾端背外侧亚核(CDL)能引起血压升高、心律失常、心肌缺血等反应。一些研究指出,刺激外周神经模拟针刺穴位能抑制CDL诱发的升压反应与心律失常,但能否抑制CDLExperiments were performed on vagotomized male rabbits weighing 1.8-2.2 kg. Urethane and chloralose were administered intravenously, and were paralyzed by flaxedil. After a caanula was inserted into femoral artery to measure blood pressure, the epicardial electrogram (EECG) was recorded. Then we inserted a bipolar electrode into caudal dorsolatera[ subdivision of periaqueductal grey (CDL), or dorsomedial hypothalamic nucleus (DMH). In some animals., a microinjecting lube was insetted into CDL for microinjection of enkephalin antibodies. In 12 animals, slimulation of CDL could elicit pressor response and elevation of EECG-ST segment. When stimulating deep peroncal nerve, these two responses were inhibited. In 14 animals, with brainslem transected in P5 level, the stimulation of DPN could not inhibit the presser response induced by CDL, but still inhibited the EECG-ST segment changes. After enkephalin antibodies were injected into CDL, DPN could not inhibited EECG-ST changes. In 4 animals, instead of enkephalin antibodies, rabbit serum had no effects. The unit discharges of 96 neurons in CDL were recorded by glass microelectrodes, among them, 15 neurons could be excited by DMH stimulation. We called these neurons the defence reaction related neurons. Stimulation of DPN or median nerve could inhibit the spontaneous discharge and DMH evoked discharge of these defence reaction related neurons. Conclusions: 1. DPN slimulation can inhibit the pressor response and cardiac ischemia induced bv defence reaction centre in CDL of PAG. The inhibitory effect on cardiac ischemia is still eminently remained after the brainstem is cut in P5 level to eliminate the influence of hypothalamic arcuate nucleus. Local enkephalin may be involved in this inhibitory process. 2. The inhibitory process is present in the defence reaction centre at CDL of PAG during the acupoint inhibition of cardiac ischemia induced by DMH stimulation, which means that midbrain defence reaction centre may be directlyinhibited by stimulating the acupoint zusanli or neiguan, in the inhibitory process of central cardiac ischemia.
摘要:国内外的工作表明中脑导水管周围灰质(Pariagueauctal grag,简称PAG)是与镇痛作用密切相关的神经结构,也是微量注射吗啡和电刺激可产生最有效镇痛作用的脑区。此部位阿片受体较为密集。朱丽霞等人认为PAG是针刺传入信号和伤害性刺The effects of stimulating periaqueductal gray (PAG) on the nociceptive neuron discharges of ponucleus evoked dy stimulating the splanchnic nerve in cats were studied. The two kinds of inhibitory action were observed. One was called early phase or prompt inhibition phase which occured within 30 ms to 150 ms after stimulation of PAG. The other was called slow-pase or sustained inhibition which occured from a few minutes to more than ten minutes after the stimulation of PAG. The results showed that PAG played an important role in the analgesia of visceral rain. Both kinds of inhibition may be blocked by naloxone, this suggests that endogencus opiate like substances involved in these inhibitory processes caused by stimulating role in the inhibitory effect of PAG.
摘要:研究指出,丘脑腹后外侧核(VPL)可接受躯体伤害性传入信息,在VPL中可记录到对伤害性刺激出现放电增加和放电减少的痛反应神经元。表明VPL某些神经元对伤害性刺激的反应与丘脑非特异投射系统核团中痛反应神经元的活动相似The somatic and visceral noxious stimuli could simultaneously induce the increase of discharges of pain-excitation neutons (PEN) and the decrease of discharges of pain-inhibition neurons (PIN) in the Nucleus Ventralis posterolalis(VPL) of thalamus in the rat, and the electric activities of the two kinds of neurons cooperated each other. By the injection of morphine (5mg/kg) and the electroacupuncture of "Zusanli", the discharges of PEN were reduced and the discharges of PIN were enhanced. The results suggested that VPL of thalamus in the rat be ifivolved in the modulating action on pain sensation and the analgesic effects of morphine and electroacupuncture by the simultaneous electric activities of PEN and PIN in VPL.
摘要:近年来的电生理学研究表明,前额叶(Prefrotal Cortex,PFC)在镇痛和痛觉调制方面具有一定作用,丘脑束旁核(Parafascicular nucleus,N.pf)是目前已确认的痛觉调制中枢。神经解剖学也已证实前额叶与丘脑前核(内侧核和髓板The effects of PFC stimulation on spontaneous and evoked discharges of neurons of rapafascicular nucleus of thalamus were observed in rats. The results show that after PFC stimulation spontaneous of 78.7% PEN (48/61) and evoked discharges on noxious stimulation of 76.6%PEN (46/60) were decreased; spontaneous discharges of 72%PIN (18/25) were increased; inhibition response on noxious stimulation of 70.80% PIN (17/24) were decreased; and spontaneous disharges of 66.7%CON (6/9) and evoked discharges on noxious stimulation of 55.6% CON (5/9) were decreased. The results suggest that PFC might have analgesia action which was accomplished by modulating electric activities of pain-related neurons of parafascicular nucleus in thalamus.
摘要:一般认为针刺镇痛效应存在着穴位相对特异性,如“腰背委中求……”即是对此的描述,而且认为这种特异性和神经系统有关。丘脑腹侧基底核(VB)是躯体感觉特异传导系统第三级神经元所在地,近年来不少资料提示VB和伤害性信息传递有关。与The purpose of the present study was to compare the effects of electroacupuncture at different points on nociceptive responses of VB neurons. The experiments were carried out on rats (280—320g) anaesthetized with urethane (19/kg,i.p.). Single unit activities of VB neurons were extracellularly recorded by means of glass microelectrodes. Noxious stimulation was subcutaneously applied at the left ankle joint by inserting two stainlessneedles. The experiments were divided into three groups. EA. Ⅰ, EA, Ⅱ and EA. Ⅲ. The corresponding points being selected for electroacupuncture in the above three groups were the left "Huantiao" (G30) point, the right "Huantiao" point and the left "Jianlian" (T14) point. The results showed that electroacupuncture at the points in the three groups all could inhibit the nociceptive responses of VB neurons, but electroacupuncture an the left "Huantiao" point (n=11) was more effective than either at the right "Huantian" point (n=9) or at the left "Jianliao" point (n=10). There was a significant difference among the three groups. However, there was no significant difference between EA. Ⅱ and EA. Ⅲ. Thus, the results indicate that there is a relative specificity of points in acupuncture analgesia.
摘要:多年来,人们对痛觉调制的研究主要集中于阿片类物质,大量的实验资料表明,各级中枢的阿片肽均参与痛觉调制。近来,人们对非阿片类神经肽在痛觉调制方面是否起作用开始感兴趣。精氨酸加压素(AVP)是下丘脑室旁核(PVN)分泌的一种非阿片类的9肽。已有实验表明,中枢或外周给予AVP可Recent evidence has indicated that vasopressin (VP) can increase the pain threshold. It is not clear whether the paraventricular nucleus (PVN) of hypothalamus, which is one of the main nuclei that secrete VP in brain, is involved in the acupuncture analgesia (AA). The present study was designed to examine the role of PVN in AA. Experiments were carried out on Wistar rats using tail stimulationvocalization test to measure the pain threshold. The acupoints "Renzhong" and "Chengjiang" were selected for electroacupuncture. Electrical stimulation of PVN could increase significantly the pain threshold and enhance the effect of AA. On the contrary, electrolytical lesion of PVN could decrease the effect of AA obviously, which could be recovered by introcere-broventricular injection (ICV) of 300 ng of arginine VP. Pretreatment with AVP-antiserum (ICV) could attenuate the effect of AA. These data indicated that PVN plays an important role in pain modulation and in the effect of AA. This role might be mediated by the VP-containing neurons in PVN.
摘要:文献中关于孤束核的形态及生理功能有很多报导,已知孤束核不仅和脑内很多核内及脊髓有着广泛联系,而且近年来发现孤束核内存在着多种神经递质,特别是存在着一些与痛疼有关的神经递质,如P物质(SP)、脑啡肽、5-羟色胺等。因此关于孤束核的功能,除作为内脏活动中枢外,它Six pairs of rats were used in the experiment. The sciatic nerve was stimulated in one of every pair with the electric needle. Then the substance P (SP-like immunoreactive nerve fibers in the nucleus of the solitary tract (NST) were showed with immunohistochmical technique (ABC METHOD)。
摘要:我们已往的实验证明,延髓是针刺镇内脏痛的重要整合部位,内脏神经传入冲动在延髓内有一定投射分布。过去,我们用强电刺激内脏大神经中枢端作为内脏伤害性刺激,由此引起延髓细胞放电、皮肤电、腹肌肌电、动脉血压、瞳孔、胃电等一Experimentes were carried out on 164 rabbits. The transmission of abdominal vagal impulses and the mechanism of inhibitory effect by acupuncture systematically were investigated: 1) Electrical stimulation (single pulse of 20V, 0.5ms) of abdominal vagus nerve (AVN) produced two kinds of potential on cervical vagus nerve: the fasl wave (10.4—24.4 M/sec) and the slow wave (0.9—1.7 M/sec), the later was more stable. 2) In dorsal medulla oblongata the 'M' shaped evoked potentials with long duration (100 ms or so) were recorded. The results suggest that afferents from AVN are mainly transmitted through the small fibres and multi-synaptic connections in Medulla. 3) Out of 301 response units, 281 units (93.6%) concentrated in NTS and adjacent regions. This result was also confirmed by injection of Horseradish Peroxides (HRP) in the trunk of AVN. 4) On 24 awake rabbits the VSR were elicited by strong stimulation of AVN. Electroacupuncture (EA) on "Zusanli" points inhibited VSR, an effect lasted over 20 min. This inhibitory effect of EA was reversed partly by Naloxonc (0.5 mg/kg iv) and was attenuated after lesion (DC 0.5 mA, 1 min.) of NTS. In conclusion, NTS plays an important role in suppression of VSR by EA (P<0.01).
摘要:红核属锥体外系,其主要机能是调节躯体运动和肌紧张。但近年来的工作指出它与感觉的调制也有关。如电刺激红核可抑制大鼠的伤害性行为反应。刺激红核可兴奋中缝大核(NRM)神经元的电活动,而刺激NRM可加强电针在三叉神经脊束核尾侧The modulation of red nucleus (RN) to pain sense was researched with the latent period of radiant-heat tail flick of rats as standard of the pain threshold. The pain threshold of tail flick reflex was raised significantly by bilateral injection of glutamic acid into RN. Simultaneous injecting glutamic acid into RN and lidocaine into nucleus raphe magnus (NRM) could attenuate the raising effect of pain threshold of RN. This showed that the activited RN has analgesic effect and the NRM plays an important role in the descending inhibitory pathway of RN. The discharges of neurons in caudalpart of nucleus spinalis tract nervi trigemini (cNST) evocked by stimulating nerve alveolaris inferior (nAI) with strong pulse were recorded with microelectrode. The nAI-evoked discharges might be inhibited by stimulating contralateral or ipsilateral RN. The RN inhibitory time course on nAI-evoked discharges were shortened after injecting lidocaine into NRM. This demonstrated that the inhibitory effect of RN on neurons in cNST is mediated by NRM. The electrical stimulation of acupoint "Jiache" could inhibit the pain-evoked discharges of neurons in cNST. The inhibitory time course of electrical acupundture were prolonged by stimulating RN. This result revealed that the activated RN can strenthen the analgesic effect of acupuncture.
摘要:电针对脑电图癫痫波有抑制作用。并证明电针抑制痫波与内啡肽、五-羟色胺、r-氨基丁酸有关。但是,电针对于单个神经元的癫痫样放电有何作用,电针不同穴位以及用不同参数电针穴位对于神经元痫样放电的影响有何差异?迄今为止还尚无In our present study we build up a new experimental model in the rat for epilepsy by intracerebroventricular injection of Coriaria Lactone (CL) and examine the effects of electroacupuncture on epileptiform hippocampal unit activity. Three types of hippocampal units responding to CL were observed:a) positive units b) negative units and c) indifferent units. The activity of positive units may be the typical epileptiform hippoeampal activity. The positive units can be inhibited by electroacupuncture (EA), weile the negative units can be exhilarated by EA. No changes were observed in indifferent units. Inhibitory effects of positive units are different because of using different "acupoints". EA of Du-Mo and Taichong Kunlun in the other side of drug injection were significatively better than Taichong Kunlun in the same side of drug injection. Effects of Du-Mo was significatively better than the effects of the points on the limb. Parameters of EA are significatively different in other side of limb points for inhibition of positive units:5V 1Hz, 5V 5Hz>1V 5Hz>1V 1Hz. These data indicate that effects of EA are depend on amplitude of EA, and seem not to be concern with frequencies of EA. The amplitude and frequency of hippocampal EEG spikes can be inhibited by EA. The inhibitory role of EA on epileptiform discharges is also discussed in this paper.
摘要:胆石症为临床常见病及多发病之一。据统计约有10%的成年人患有此病。《针灸学简编》一书曾谓肝俞穴有舒肝利胆之作用,脾俞穴则治黄疸等症。而梁门穴有缝脾胃助运化的作用。期门穴有疏肝理气之功能。此外,有关肝俞、脾俞、期门、梁One hundred guinea pigs were used. The 10% HRP 50—60 μ1 solution was injected into the acupoints of "Gansu", "Pisu", "Liangmen" and "Qimen" of every animal. Moreover, the 10% HRP 80—100 solution was injected into the gallbladder of the another animals too. Under the microscope, observed the segmental distributions of sensory neurons of the four acupoints and the gallbladder. It could be found much clearly that HRP labelled cells were appearing in the spinal ganglions. The above experimental studies showed that there are mutual intersect 5—7 segments between the gallbladder and the "Gansu", "Pisu", "Liangmen" and "Qimen" four acupoints. It is probable that the mutual intersect is the neuroanatomic foundation of acupuncture and moxibustion to inhibit the formation of bilirubin gallstones.
摘要:呕吐是多种疾病常见的临床症状。有研究证实:呕吐有相关的异常胃肠电活动。临床与实验表明,针刺对消化系疾患有良好的疗效,针刺对胃肠电有双向调节作用。针刺有无镇吐效应?针刺镇吐作用机理如何?乃是本研究目的。我们在Acute experiments were performed on 20 guinea pigs. The animals were divided at random into four groups of five each. the nonacupuncture group for control and three electroacupunctured groups (EA-Ⅰ, EA-Ⅱ, EA-Ⅲ). Four pairs of platinum-wire electrodes were implanted under serosa of the antrum and corpus, duodenum, jijunum. The gastroenteric electric activity (GEA) was recorded in conscious and fasting state. Needling was applied at position lcm below the knee, corresponding to Zusanli. The peripheral vomitng model was established by infusion of CuSo_4 into the stomach. Observation was made with regard to latency of vomiting induced by infusion of CuSo_4, duration of the symptom, number of fits in the pirst five msnutes after the attack began, and the variation of amplitude and frequency of GEA. The results were as follows: (1) The GEA of normal guinea pigs showed regular cyclic changes. After latency of 3.7 seconds following the infusion, symptom of vomiting began appear. The GEA returned to normal after latency of 60 minutes. (2) During vomiting, the GEA was characterized by a series of spikes whichwere seen more obseously in the antrum and corpus; during serious fits of vomiting, duodenum and jijunum were involved. The GEA showkd disordered and quicker rhythm with higher amplitude and frequency. (3) EA could not affect the latency of the peripheral vomiting, but It could shorten the duration of the symptom. Results of group EA-Ⅱ(p<0.001) showed EA could reduce the number of fits during the first five minutes; results og group EA-Ⅰ(p<0.01) showed that EA could lower the amplitude and frequency of the GEA (p<0.05) that rose during vomiting. This indicates that EA has certain regulating effect on the GEA of peripheral vomiting. The mechanism of EA on anti-emesis was primaryly discused.
摘要:留针法是针刺治疗中的一个重要环节、古代文献中对此具有专门的论述、如“热则疾之,寒则留之”(灵枢·经脉),“久病者、深内久而久留之”(灵枢·终始),“婴儿者,浅刺而疾发针”(灵枢·逆顺肥瘦)等,并且认为留针是否得当可直接影This is an observation of the relationship between tile retention of acupu- ncture needles and its effect on nose temperature in seventy-four patients with facial nerve paralysis. The patients were divided into five groups according to the period of retention of needles: no retention, retention for ten, twenty, thirty and fourty minutes. Every group consisted twenty cases. The results showed that (a) the nose temperature lowered after acupuncture immediately; (b) then it rose and reached to the maximum at twenty minutes after acupuncture, then lowered again; (c) for the group of no retention and retention for ten and twenty minutes, the temperature rose again during thirty to fourty minutes afteacupuncture, for the group of retention for thirty or fourty minutes, howevere, without these phenomena; (d) the general tendency was that the change of temperature was bigger but lasting for shorter period in the groups of etentionfor longer time than that in the groups of retention for shorter time. These results verified that some theory in ancient books about the retention of acupuncture needles are scientific.