最新刊期
2002年第1期
- 摘要：目的 :观察针刺对缺血再灌注脑组织形态结构和酶活性的影响。方法 :采用闭塞大鼠四条动脉的全脑缺血再灌注模型 ,以组织化学方法观察缺血再灌注脑组织形态结构的变化及针刺对其变化的影响 ,同时测定脑组织中丙二醛 (MDA)含量和谷胱甘肽过氧化物酶 (GSH px)、离子泵的活性及针刺对其活性的影响。结果 :缺血再灌注组出现明显的神经细胞变性、死亡和胶质细胞增生现象 ,针刺治疗组Ⅱ无明显的细胞受损后形态学变化 ;缺血组和缺血再灌注组MDA含量显著高于假手术组 ,经针刺治疗后MDA含量明显下降 ;GSH px活性在脑缺血过程中首先代偿性升高 ,在再灌注过程中明显下降 ,经针刺治疗后酶活性复又升高 ;离子泵的活性在缺血及再灌注过程均有不同程度的下降 ,经针刺治疗后各离子泵的活性均升高至与假手术组相近。结论 :在缺血和再灌注过程中神经元的变性乃至死亡与膜脂质过氧化作用加强、自由基清除能力下降及能量代谢异常密切相关 ,而针刺“百会”和“曲池”可有效改善缺血再灌注造成的神经元延迟性损伤。关键词：针刺;缺血再灌注;形态结构;MDA;GSHpx;ATPase1025|0|0更新时间：2023-08-11
- 摘要：目的 :观察预刺激脑缺血大鼠小脑顶核不同时相蛋白激酶C同工酶γ、δ蛋白表达。方法 :采用线栓法大鼠大脑中动脉栓塞 /再灌注模型 ,缺血时间均为 1 .5hr/再灌注 2 4hr;于缺血前1、4、7天分别刺激小脑顶核、齿状核 1hr。以尾状核冠状切面作为观察对象 ,应用免疫组织化学方法观察单纯缺血 /再灌注组、假手术组、刺激小脑顶核组和刺激齿状核组PKCγ、δ的表达情况。结果 :缺血前 1、4、7天刺激小脑齿状核各组、单纯缺血 /再灌注组、假手术组PKCγ、δ阳性细胞数比较无显著性差异 (P >0 .0 5) ,而缺血前 1、4、7天预刺激小脑顶核能明显抑制PKCγ、δ蛋白的表达(P <0 .0 5)。结论 :缺血性脑损害能诱导PKCγ、δ蛋白表达上调 ,预先电刺激小脑顶核的缺血脑保护作用可能与其下调PKCγ、δ蛋白表达有关Objective: To investigate whether electrical fore stimulation of cerebellar fastigial nucleus(FN) could influence changes of cerebral PKC γ and PKC δ expression in cerebral ischemia reperfusion (I R) rats . Methods: 48 Wistar rats were randomly divided into I R group, sham operation group, DN stimulation (S) group and FN S group, and each of the later two groups were further divided into 3 groups according to fore stimulation duration (one day, 4 days and 7 days). The middle cerebral artery occlusion and reperfusion(MCAo R) model was performed in Wistar rats using intraluminal cauterized catgut ball blocking method. Cerebellar FN and DN (Dentate Nucleus) were stimulated electrically for 1 hr, one day,4 days and 7 days before MCAo R(1.5 hr/24 hr). PKC γ, PKC δ protein expression was determined with immunohistochemical staining technique. Results: PKCγ and δ positive reaction cells distributed in cerebral cortex, hippocampus and the ischemic half shadow area. There were no significant differences among I R group, sham operation group, DN stimulation (S) subgroups (1 day, 4 days and 7 days) in PKCγ and δ positive cell counts (P>0.05), but in comparison with DN stimulation subgroups, the positive cells in FN stimulation subgroups were significantly fewer (P<0.01), which even lasted 7 days (P<0.05). Conclusion: Cerebral ischemia can induce abnormal expression of PKC γ and PKC δ, and FN fore stimulation generated down regulation of PKCγ and δ expression may contribute to its protective effect on cerebral ischemia.关键词：脑缺血;小脑顶核;PKCγ;PKCδ955|0|1更新时间：2023-08-11
- 摘要：目的 :观察电针 (EA)对局灶性脑缺血 /再灌注大鼠IL 1RamRNA表达的调节作用。方法 :采用线栓法制备SD大鼠局灶性大脑中动脉阻塞缺血 /再灌注 (MCAo)模型 ,并应用RT PCR的方法进行观察。结果 :MCAo大鼠缺血侧大脑皮层在再灌注后 1 2hr和 2 4hrIL 1RamRNA表达增加 ;在缺血侧纹状体缺血再灌注后 1 2hrIL 1RamRNA表达明显增加 ,但再灌注后 2 4hr表达明显降低 ,电针可使IL 1RamRNA的表达明显增加。结论 :EA可使内源性IL 1RamRNA表达增加 ,从而使IL 1Ra表达增加 ,对脑缺血起保护作用 ,这也可能是EA抗脑缺血损伤的机制之一。关键词：脑缺血;针刺;白细胞介素-1;受体拮抗剂(IL-1Ra)1052|0|6更新时间：2023-08-11
- 摘要：目的 :本工作试图阐明孤啡肽 (OFQ)在脑缺血中的作用 ,并观察它对针刺抗脑缺血的影响。方法 :采用大鼠大脑中动脉栓塞模型 ,应用侧脑室注射方法以体感诱发电位 (SEP)和脑梗塞体积为指标观察了不同剂量的孤啡肽对脑缺血的作用 ,以及对针刺抗脑缺血的影响。结果 :大鼠大脑中动脉栓塞后SEP波幅降低 ,侧脑室注射 1 0 μg和 1 μg孤啡肽均进一步降低SEP的波幅 ,对照组在再灌后 1hrSEP基本恢复 ,而侧脑室注射孤啡肽 1 0 μg直到再灌后 3hr仍不恢复。注射剂量与SEP反应呈一定的量 效关系 ,即剂量越大 ,SEP抑制越显著。同时增大了脑梗塞灶的体积。而相同条件下侧脑室注射 0 .1 μg孤啡肽SEP的波幅和脑梗塞灶的体积与对照组比较无显著性差异。电针能减小脑梗塞体积 ,增大SEP的波幅。侧脑室注射 1 μg孤啡肽后针刺效应减弱 ,表现为SEP的波幅降低 ,脑梗塞灶的体积增大。结论 :侧脑室注射孤啡肽可加重脑缺血 ,且减弱了针刺抗脑缺血的作用。关键词：电针;脑缺血;孤啡肽;体感诱发电位923|0|1更新时间：2023-08-11
- 摘要：目的 :观察针药结合对脑缺血大鼠脑组织内活性钙调素 (CaM)含量变化的影响。方法 :采用大鼠全脑缺血再灌注模型 ,用磷酸二脂酶法测定正常对照组、模型对照组、电针四肢井穴加药组、电针四肢井穴组、假手术对照组脑组织活性CaM的含量。结果 :造模后CaM显著升高 (P <0 0 5～ 0 0 0 1 ) ,经电针治疗及针药结合治疗后CaM显著下降 (P <0 0 0 1 ) ,但针药结合治疗与单纯电针治疗组之间降低CaM的作用无显著差异 (P >0 0 5)。结论 :电针、针药结合均可明显降低脑缺血再灌注大鼠脑组织中活性CaM的含量。关键词：脑缺血;电针;井穴;钙调素含量1168|0|1更新时间：2023-08-11
- 摘要：目的 :探讨针刺治疗脑梗塞的机理。方法 :采用血管内皮细胞荧光染色及白细胞荧光示踪法 ,结合显微录像系统和计算机图像分析系统 ,动态定量地观察了针刺对MCAo后 3、6、2 4hr软脑膜微血管形态、密度、血流速度的影响。结果 :①模型组各时段微血管内皮细胞着色差 ,组织渗出荧光多 ,针刺组明显好于模型组。②各时段模型组缺血区软脑膜微血管密度明显降低 ,针刺组微血管密度明显高于模型组。③各时段模型组缺血区软脑膜微血管血流速度降低 ,而针刺组流速较模型组明显提高。结论 :针刺能及时有效地改善MCAo后脑微循环灌注状态。关键词：脑梗塞;针刺;脑微循环978|0|7更新时间：2023-08-11
- 摘要：目的 :研究不同强度的电针对大鼠脑内P物质表达的影响。方法 :在电针大鼠下肢“足三里”穴位后 ,用免疫组织化学的方法观察了电针后 2 4hr大鼠尾壳核、杏仁核、下丘脑室旁核、下丘脑前区、导水管周围灰质P物质表达的变化。结果 :电针组较对照组上述部位P物质表达阳性细胞数明显增高。结论 :电针可引起脑内上述部位P物质表达增高 ,而P物质表达的增高可能在调节机体许多生理功能中起重要作用Objective: To study the influence of different intensity of electroacupuncture (EA) on substance P(SP) expression in rat brain. Methods: Nine SD rats were randomly divided into control group, high intensity EA group and low intensity EA group. "Zusnali" (ST 36) was punctured with filiform needles and stimulated electrically by setting the stimulating strength being 1 mA (low intensity) and 5 mA (high intensity), wave width 0.1 ms, frequency 50 Hz and duration of 30 min. SP expression was displayed with immunohistochemical method. Results: Twenty four hours following EA stimulation, SP expression positive cells were found in caudate putamen, hypothalamic paraventricular nucleus, anterior hypothalamic area, amygdaloid nucleus and periaqueduct grey matter. SP expression positive cells in these nuclei or area in two EA groups were significantly more than those of control group (P<0.05), while those of low intensity EA group were evidently more than those of high intensity EA group (P<0.05). Conclusion:EA can induce up regulation of SP expression in the aforementioned brain regions and the resultant enhancement of SP expression may play an important role in regulating a variety of physiological functions in the body.关键词：P物质表达;电针;脑;大鼠825|0|2更新时间：2023-08-11
- 摘要：目的 :观察不同电针对大鼠脑出血模型海马组织氨基酸含量的影响 ,探讨电针对脑出血大鼠保护作用的可能机制。方法 :选择胶原酶加肝素联合注射法诱导脑出血大鼠模型 ,采用反相高效液相色谱荧光法观察电针不同穴位对大鼠海马氨基酸含量的影响。结果 :造模后模型组海马组织兴奋性氨基酸 (ASP、Glu)和抑制性氨基酸 (GABA)明显升高 ,存在着兴奋性氨基酸 (EAA) /抑制性氨基酸 (IAA)平衡失调。针水组能降低造模所致的Glu和GABA的升高 ,和模型组比有显著性差异 (P <0 .0 5) ,而对ASP的降低作用不明显 ,和模型组比无显著性差异 (P >0 .0 5) ;针风组能降低造模所致的ASP和Glu的升高 ,和模型组比有显著性差异 (P <0 .0 5) ,而对GABA的降低作用不明显 ,和模型组比无显著性差异 (P >0 .0 5)。结论 :针水组、针风组能抑制不同兴奋性氨基酸(Glu、ASP)的释放 ,纠正兴奋性氨基酸 (EAA) /抑制性氨基酸 (IAA)失衡 ,从而达到减轻脑出血后脑组织损害的作用。关键词：脑出血;电针;兴奋性氨基酸;抑制性氨基酸1179|0|3更新时间：2023-08-11
- 摘要：目的 :观察艾灸治疗实验性豚鼠哮喘病中NO(一氧化氮 )与M受体的相互关系。方法 :采用 50只 2 50～ 3 0 0 g的雄性豚鼠 ,随机分成 :A 健康对照组 ,B 实验哮喘组 ,C 哮喘 +艾灸组 ,D 哮喘 +L NAME组 ,E 哮喘 +L NAME(L 精氨酸甲酯 ) +艾灸组共五组 ,用放射性配基结合实验的方法测定肺组织细胞膜M受体Bmax和平衡离解常数 ,用NO检测试剂盒测各组豚鼠BALF(支气管肺泡灌洗液 )、肺组织、血中NO的含量。结果 :与健康组相比 ,哮喘组豚鼠BALF中NO含量升高 ,肺细胞膜制剂对3H QNB结合的Bmax上升 ;与哮喘组相比 ,哮喘 +艾灸组及哮喘 +L NAME +艾灸组豚鼠BALF中NO含量下降 ,肺细胞膜制剂对3H QNB结合的Bmax降低 ,哮喘 +L NAME组豚鼠BALF中NO含量降低 ,而肺细胞膜制剂对3H QNB结合的Bmax无明显变化。结论 :艾灸“肺俞”等穴可降低哮喘引起的肺组织和肺泡灌洗液中NO水平及细胞膜Bmax的增加 ,NO与Bmax在灸法缓解哮喘过程中呈正相关关系Objective:To investigate the role and correlation of nitric oxide (NO) and M receptor in moxibustion treatment of asthma in guinea pigs. Methods: 50 guinea pigs were randomly and evenly divided into five groups: ① control group,②asthma group,③ moxibustion group,④ L NAME (non selective inhibitor of NO) group,and ⑤L NAME + moxibustion group. Asthma model was established by intraperitoneal injection of 10% egg albumin saline (1 mL) and inhaling 1% aerosol egg albumin in guinea pigs. The 3H QNB(quinuclidinyl benzilate) combined Bmax and equilibrium dissociation constant (Kd) of M receptor on the lung tissue cell membrane were calculated using Scatchard formula according to the detected radioactivity value with radioaligand binding assay, and NO levels of plasma, bronchoalveolar lavage fluid(BALF)and lung tissues were assayed according to instructions of the reagent kit. Bilateral "Feishu" (BL 13), "Dazhui" (GV 14) and "Dingchuan" (EX B 1) were moxibustioned for 20 min.Results: Results indicated that Bmax level of 3H QNB combined M receptor of asthma group and asthma+L NAME group increased significantly in comparison with those of control group (P<0.01); there were no significant differences between moxibustion and control groups, and between moxibustion+L NAME and control groups, suggesting an inhibitory effect of moxibustion on Bmax. In spite of being higher of kd value in moxibustion group, no significant differences were found among the 5 groups (P>0.05). Regarding NO content changes, there were no significant differences among the 5 groups in plasma NO; while BALF and lung tissue NO contents of asthma group increased considerably in comparison with the other 4 groups (P<0.01), but no significant differences were found between moxibustion, or L NAME, or moxibustion+L NAME groups and control group, indicating a down regulative action of moxibustion on BALF and lung tissue NO levels. In asthma model group, moxibustion group and moxibustion+L NAME group, a positive correlation between nitric oxide level and Bmax of M receptor exists(γ=0.732, 0.718, 0.716,P<0.05),and L NAME had no obvious affection on the Bmax of M receptor.Conclusion:Moxibustion can suppress asthma induced increase of NO contents in the lung tissues and BALF and Bmax level; and there exists a positive correlation between NO level and Bmax of M receptor.关键词：哮喘;一氧化氮;M受体;放射性配基结合实验999|0|1更新时间：2023-08-11
- 摘要：目的 :观察在背根反射和轴突反射实验条件下 ,穴位刺激对内脏组织的效应。方法 :以神经源性炎症反应作为经络活动的指标进行观察。结果 :电刺激“足三里”穴经背根反射和长轴突反射可引起胃肠道等消化系统内脏的神经源性炎症反应 ,而其他内脏组织不出现类似反应 ,这与我们以前刺激“承山”穴引起泌尿、生殖系统内脏的反应形成鲜明对照 ,为揭示经脉 脏腑相关联系提供了一种新途径。如果实验前 6天预先给穴位注射辣椒素 ( 6 6mM ,50 μL) ,则电刺激穴位后相关内脏组织出现的Evans蓝渗出被阻断。结论 :穴位刺激引起内脏组织的神经源性炎症反应是由辣椒素敏感的传入纤维介导的。关键词：经脉-脏腑相关;神经源性炎症反应;长轴突反射;背根反射;传入纤维的逆向传出功能;辣椒素1002|0|15更新时间：2023-08-11
- 摘要：目的 :观察电针“足三里”对大鼠脑肠肽含量的影响及其对免疫系统的调控作用。方法 :将大鼠随机分成正常对照组、非经非穴组、免疫抑制组、“足三里”组、“足三里” +免疫抑制组。应用放射免疫法测定脑垂体和外周血P物质放免活性 (ir SP)和血管活性肠肽放免活性 (ir VIP)含量的变化 ;应用流式细胞仪技术 ,通过微量全血直接免疫荧光染色法测定外周血T细胞亚群以反映细胞免疫功能 ;应用红细胞C3b受体 酵母菌花环试验和红细胞 IC花环试验检测红细胞免疫功能。结果 :电针刺激“足三里”穴可提高正常大鼠和免疫抑制大鼠的细胞免疫功能和红细胞免疫粘附功能 ,同时 ,脑垂体和外周血中ir SP、ir VIP的含量也明显升高。结论 :针刺治疗可以提高机体免疫力 ,其机理可能与相应脑肠肽的合成和释放增多有关 ,并通过这些免疫递质对神经 内分泌 免疫调节网络发挥作用。关键词：电针;“足三里”;P物质;血管活性肠肽;红细胞免疫;T细胞亚群1696|0|6更新时间：2023-08-11
- 摘要：目的 :研究电针“足三里”穴对大鼠T细胞亚群和红细胞免疫粘附能力的影响。方法 :应用流式细胞仪技术 ,通过微量全血直接免疫荧光染色法测定各组大鼠的外周血T淋巴细胞亚群以反映细胞免疫功能 ,应用红细胞C3b受体 酵母菌花环试验和红细胞 IC花环试验检测红细胞免疫功能。结果 :电针“足三里”穴组大鼠T4细胞百分率、RBC C3bRR、RBC ICR明显高于正常对照组 (P <0 .0 1 ) ,CD8+无明显变化 (P >0 .0 5) ;免疫抑制模型组的大鼠T4细胞百分率、RBC C3bRR明显低于正常对照组 (P <0 .0 5) ,T8细胞百分率、RBC ICR与正常对照组相比无明显变化(P >0 .0 5) ;免疫抑制 +“足三里”组大鼠T4细胞百分率、RBC C3bRR、RBC ICR与免疫抑制组相比有明显改善和提高 (P <0 .0 1 )。结论 :电针“足三里”穴可提高正常大鼠与免疫抑制模型大鼠的T细胞免疫功能及红细胞免疫粘附能力。关键词：电针;“足三里”穴;细胞免疫1030|0|4更新时间：2023-08-11
- 摘要：目的 :从单次电针实验和多次电针实验两方面 ,观察电针对神经痛大鼠痛敏分数的影响。方法 :采用轻微结扎一侧大鼠坐骨神经的神经痛模型 ,以光热辐射引起的大鼠双下肢抬脚潜伏期的差值作为神经痛的指标 (痛敏分数 )。结果 :即刻电针可明显减小神经痛大鼠的痛敏分数绝对值 ,随着电针次数的增加 ,大鼠痛敏分数绝对值逐渐恢复 ,呈现出累积效应。结论 :电针对神经痛大鼠具有显著的镇痛作用 ,而多次电针有累积性疗效Objective:To observe the effect of single electroacupuncture (EA) treatment and multiple EA treatment on hyperalgesia score of neuropathic pain in the rat. Methods:SD rat CCI (chronic constriction injury) hyperalgesia model was used as the neuropathic pain model, and hyperalgesia score employed as the sign of neuropathic pain. In single EA treatment experiments, 12 hyperalgesia rats were randomly divided into control group and EA group, while in multiple EA treatment experiments, 20 hyperalgesia rats were randomly divided into control and EA groups. Results: ① Before single EA treatment, the basal hyperalgesia scores of control group and EA group were -3.035±0.222 and -2.870± 0.332 respectively, having no significant difference between them. Following single EA stimulation, the absolute values of the hyperalgesia score decreased significantly from 20 min to 60 min after EA in comparison with control group (P<0.05). ② In multiple EA treatment experiments, the basal hyperalgesia scores of EA group and control group were -2.030±0.170 and -2.239±0.268, showing no significant difference between them. Along with increase of EA times, the absolute values of the hyperalgesia score decreased gradually. On the 12th, 14th, 21st, 24th, 26th and 28th day, the hyperalgesia scores were significantly lower than those of control group (P<0.05) and those of the 3rd week (21st～28th day after operation) were even more evidently than those of the first two weeks (P<0.05). Results showed that multiple EA treatments had an obviously accumulative effect on analgesia. Conclusion: EA could produce immediate analgesia action and have an accumulative effect.关键词：电针;痛敏分数;神经痛895|0|6更新时间：2023-08-11
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- 摘要：目的 :检测IL 1 β、IL 6在类风湿性关节炎 (RA)的表达 ,探讨蜂针治疗RA的作用机理。方法 :将 40只大鼠随机分为四组 ,采用PCR微板核酸杂交 ELISA方法检测滑膜IL 1 β、IL 6的mRNA表达水平。结果 :蜂针组和激素组IL 1 β、IL 6的mRNA表达水平无显著性差异 ,而与模型组比较有显著性差异。结论 :RA早期IL 1 β、IL 6的mRNA表达水平是上调的 ,蜂针治疗后可以抑制其转录和表达 ,有利于RA病情的缓解Objective: To study the effect of acupoint apitherapy on the expression of IL 1β mRNA and IL 6 mRNA and to analyze its mechanisms in treatment of rheumatoid arthritis (RA). Methods: A total of 40 rats were randomly and evenly divided into normal control group, model group, hormone (hydrocortisone) group and acupoint apitherapy group. RA model was established by injecting Freund's adjuvant (0.05 mL)into the right hind paw. For rats of hormone group, intraperitoneal injection of hydrocortisone (10 mg/2 mL) was performed. In acupoint apitherapy group, "Shenshu"(BL 23), "Zusanli"(ST 36), "Mingmen"(GV 4) and "Dazhui"(GV 14) were stimulated with bee needle pricking method. IL 1β mRNA and IL 6 mRNA expression of synovial tissues (right knee joint capsule) was detected using PCR microplate sandwich hybridization technique. Results:In comparison with normal control group, IL 1β mRNA and IL 6 mRNA expression of synovial tissues increased considerably in model group (P<0.01). There was no statistical difference between acupoint apitherapy group and hormone group in IL 1β mRNA and IL 6 mRNA expression, but the expressions in these two groups were significantly weaker than those of model group. Conclusion:Acupoint apitherapy could induce upregulation of IL 1β mRNA and IL 6 mRNA expression in RA rats , which may be responsible for apitherapy generated relief of symptoms and signs of RA.关键词：蜂毒疗法;类风湿;IL-1βmRNA;IL-6mRNA;基因表达1051|0|3更新时间：2023-08-11
- 摘要：目的 :观察针刺对心脏植物神经的调节作用。方法 :采用心率变异性频谱分析法 ,对心脏植物神经做药物的逆同向干预后的针刺效应进行分析研究。结果 :植物神经被部分阻断后 ,针刺效应具有去药物干预样的作用。结论 :针刺疗法具有双向的良性调节作用 ,对心率变异性的调节必须依赖于植物神经 ,对心肌具有保护作用Objective: Observing the action of acupuncture on cardiac autonomic nerve activity in volunteer subjects.Methods: Twelve volunteer healthy subjects were evenly and randomly divided into Atropine group and Metoprolol group. Subjects of Atropine group were given intravenously with Atropine 1 mg, followed by puncturing bilateral Neiguan (PC 6) and Jueyinshu (BL 14) and stimulating them electrically with frequency of 0.6～0.8 Hz, 15～30 V, and duration of 10 min. In Metoprolol group, 6 subjects were ordered to take Metoprolol 12.5 mg orally, then EA was applied to Neiguan (PC 6) and Jueyinshu(BL 14)for 10 min. Heart rate variability (HRV) was analyzed to evaluate the effect of acupuncture on medicine induced abnormal changes of cardiac autonomic nerve activity. Results: Following injection of Atropine, low frequency (LF) component of HRV was increased slightly, while the high frequency (HF) component declined significantly (P<0.01), and LF/HF got smaller. After EA, both LF and HF, particularly HF component increased significantly (P<0.05). Following administration of Metoprolol, LF reduced while HF increased, and LF/HF reduced considerably in comparison with pre administration of Metoprolol (P<0.01). When EA was given for 10 min, LF increased evidently (P<0.05) and HF also increased, and LF/HF got to close to normal level. The findings indicated that acupuncture could antagonize medicine induced disorder of cardiac vegetative nerve activity.Conclusion: Acupuncture possesses dual directional regulative action on cardiac sympathetic and vagal nerve activities and can protect myocardial functions effectively.关键词：植物神经;针刺;心率变异性1027|0|10更新时间：2023-08-11
- 摘要：目的 :观察膝关节前后交替针刺加TDP照射治疗增生性关节炎的效果。方法 :采用交替针刺膝关节前部之内膝眼、犊鼻、鹤顶与委中直上约 3寸处加以TDP照射的方法治疗膝关节炎89例。结果 :临床治愈 51例 ,占 57 3 % ;好转 3 2例 ,占 3 6 % ;无效 6例 ,占 6 7%。结论 :前后交替针刺加TDP照射是治疗增生性膝关节炎的有效方法Objective: To observe the therapeutic results of acupuncture and TDP irradiation in treating proliferous knee arthritis.Methods: 89 Cases of proliferous knee arthritis were treated by alternately puncturing and TDP irradiating Neixiyan(EX LE 4), Dubi(ST 35), Heding(EX LE 2) and the point 3 cun above Weizhong(BL 40). These acupoints were stimulated with uniform reinforcing reducing manipulation with the needles retained for 30 min. The treatment was conducted once daily, 4 times every week, with 10 times being a therapeutic course. The interval between two courses was one week. Results:Following two courses of treatment, of the 89 cases, 51 (57.3%) were cured, 32 (36%)had improvement and 6 (6.7%)had no apparent changes.Conclusion: Alternate acupuncture and TDP irradiation can be used to effectively treat proliferous knee arthritis.关键词：针刺;TDP照射;膝关节炎736|0|1更新时间：2023-08-11
- 摘要：本文对胰岛素抵抗 (insulinresistance,IR)的机理研究进展作一简单概述 ,据此阐明针刺具有改善胰岛素抵抗的作用 ,并就针刺干预胰岛素抵抗的可能作用靶点提出构想 ,认为在受体前、受体及受体后水平来研究针刺改善胰岛素抵抗 ,最有可能揭示其作用机理 ,为进一步研究针刺改善胰岛素抵抗提供思路In the present study, the authors review some advances of the research on insulin resistance (IR) and the possible action target sites of acupuncture in relieving IR related diabetes, hypertension, adiposis, etc. Findings show that pre receptor and post receptor factors may be responsible for the occurrence of IR. Pre receptor factors generally include ① Insulin (Ins) gene mutation; ② formation of endogenous and exogenous Ins antigens, ③ Ins receptor antigen formation, ④ acceleration of Ins degradation, and ⑤ excessive Ins resisting hormones including glucocorticoid hormone, catecholamine, glucagon, free fatty acid, etc. The post receptor factors mainly contain ① receptor biosynthesis rate lowering induced reduction of receptor count, ② abnormal process of receptor inserting into cellular membrane, ③ reduction of receptor affinity with Ins, ④ acceleration of receptor degradation, and disturbance of receptor re utilization. The possible acupuncture target sites for bettering IR are ① lowering serum Ins level, ② raising C peptide/Ins, ③ increasing Ins resisting hormone content, and ④ elevating Ins sensitivity. The authors also put forward some suggestions about the research on mechanisms of acupuncture in relieving IR from pre receptor, receptor and post receptor levels.关键词：胰岛素抵抗;针刺;机理1043|0|2更新时间：2023-08-11
- 摘要：为了解针灸治疗变态反应性鼻炎在临床中的进展情况 ,本文对近几年文献有关资料进行了归纳总结 ,从针刺、耳穴贴压、穴位注射、穴位贴敷及穴位综合疗法等不同方面分别阐述 ,可见选取不同的穴位、施以不同的疗法 ,均取得了较好的疗效。故以针灸治疗本病具有疗效肯定、副作用小的优点。本文还对今后的临床研究方向提出了建议In the present paper, the authors reviewed advances in the treatment of allergic rhinitis (AR) by acupuncture and moxibustion in recent years. In clinic, AR can be effectively treated using ①body acupuncture, ②ear acupuncture, ③acupoint injection, ④acupiont scrapping, ⑤comprehensive therapy of acupuncture, cupping and moxibustion, or acupuncture, scrapping and cupping, or ginger separated moxibustion and acupoint plaster of Chinese herbal medicines, or acupuncture and acupoint injection, and ⑥acupoint catgut embedding, simple cupping or acupoint ultrasonic radiation. Clinical practice indicated that satisfactory effects can often be achieved through selecting different acupionts according to syndrome differentiation or puncturing topical acupoints and acupuncture moxibustion (acumoxi) treatment of allergic rhinitis has the advantages of affirmative effect and less side effects. However, some problems as non united standards for evaluating the therapeutic effect, lack of reasonable control group, etc. still exist, hindering the development of acumoxi treatment of AR and the improvement of clinical therapeutic effect. This article also put forward some suggestions on the direction of clinical research in the future.关键词：针灸疗法;变态反应性鼻炎954|0|4更新时间：2023-08-11
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