最新刊期
2005年第1期
- 摘要：目的:研究经皮穴位电刺激配合全麻行异氟醚控制性降压的临床使用可行性。方法:选择脑瘤择期手术患者4 2例,随机分为对照组和实验组,对照组采用常规全麻,实验组经皮穴位电刺激加常规全麻,各2 1例。术中用HANS电针仪电刺激双侧颧、鱼腰、风池及合谷等穴位,同时加大异氟醚浓度,使平均动脉压(MAP)较麻醉前下降30 %～4 0 %,维持30～4 5min ,观察以下项目:①两组于剪脑膜后降压前、降压30min及血压回升稳定后30min各阶段的血流动力学指标及组织氧代谢、相应血气和动脉乳酸浓度等指标。②两组降压前、中、后呼气末异氟醚浓度的变化。③麻醉苏醒恢复状况。结果:①两组动脉及肺混合静脉血气值各项指标均无明显变化,且均在正常值范围中;两组间同一时相比较,差异无显著性。②与降压前比较,降压期间肺动脉混合静脉血氧饱和度和组织氧供下降,氧摄取率增加,差异均有显著性(P <0 .0 5 ) ;DO2 、VO2 、ERO2 、SvO2 、CO、CI和ABL等指标降压中与降压前增减的百分数,实验组明显低于对照组(P <0 .0 5 )。③Sv、SI和LVSWI等参数绝对值,对照组、实验组之间同一时相比较无明显差异,而降压30min与降压前增减的百分数,实验组明显低于对照组,有显著性差异(P <0 .0 5 )。④与对照组比较,实验组在降压前、中、后呼气末吸入的异氟?Objective: To study the applicability of combined transcutaneous electrical acupoint stimulation (TEAS) and general anesthesia for cerebral surgical operation under Isoflurane-induced hypotension. Methods: Forty-two patients with brain tumor were randomly divided into Isoflurane anesthesia (control group,n=21) and combined TEAS and general anesthesia (treatment group,n=21). In treatment group, TEAS (2/100 Hz, 8～12 mA) was applied to Quanliao (SI 18), Yuyao (EX-HN 4), Fengchi (GB 20) and Hegu (LI 4) for 20 min following routine anesthesia with intravenous injection of Droperidol (5 mg), Fentanyl (4～6 μg), 2.5% sodium pentothal (5～7 mg/kg) and Pancuronium (0.1～0.15 mg/kg) and inhaling Isoflurane. For patients of control group, only routine general anesthesia was given. During the operation, the concentration of Isoflurane was elevated to reduce mean arterial pressure (MAP) 30～40% for 30～40 min. The main items for observation are 1) changes of hymodynamic parameters, blood gas and arterial blood lactic acid (ABL) concentration before, during and after hypotension; 2) changes of the end tidal Isoflurane concentration before, during and after hypotension; and 3) the restoration state of autonomous respiration and awakening from anesthesia. Results: There were no significant differences between treatment and control groups in arterial blood pH (pHa), partial pressure of arterial oxygen (PaO_2), saturation of O_2 (SaO_2) and partial pressure of CO_2 (PaCO_2), pulmonary mixed venous blood pH (pHv), PvO_2 and PvCO_2, and hemoglobin (Hb) before, during and after lowering blood pressure, and all the values were in the normal range. Compared with pre-hypotension, the dissolved oxygen (DO_2) and SvO_2 decreased significantly (P<0.05), O_2 extraction ratio (ERO_2) and ABL increased obviously (P<0.05) in these two groups. Thirty minutes after lowering blood pressure, the decreased values of stroke volume (SV), stroke index (SI) and left ventricular stroke work index (LVSWI) of treatment group were significantly lower than those of control group (P<0.05). Before and during lowering and elevating blood pressure, the end tidal Isoflurane concentrations (vol%) in treatment group was significantly lower than those in control group (P<0.05). After operation, the time for the restoration state of autonomous respiration and awakening from anesthesia of treatment group was significantly shorter than that of control group (P<0.05). Conclusion: Combined transcutaneous electrical acupoint stimulation with isoflurane induced hypotension for surgical operation can maintain stable oxygenic metabolism, lower physiological interference and reduce the side effects of the inhaled high concentration of Isoflurane, is superior to general anesthesia and thus suitable to be used for neurosurgical anesthesia.关键词：针刺麻醉;经皮穴位电刺激;异氟醚麻醉976|0|7更新时间：2023-08-11
- 摘要：目的:研究电针对佐剂性关节炎大鼠踝关节周围皮肤及皮下组织神经纤维上BSI -B4与IL -1RI荧光双标免疫反应性的影响。方法:采用免疫荧光双标技术,观察了佐剂性关节炎大鼠致炎后第3d踝关节周围皮肤及皮下组织神经纤维上BSI- B4与IL 1RI荧光双标免疫反应性,及电针胆经“环跳”穴、“阳陵泉”穴(刺激参数为0 .5～1 .5V ,4～1 6Hz ,30min)后IL 1受体拮抗剂对其是否具有调控作用。结果:①各组大鼠炎症侧外踝关节周围皮肤及皮下组织均可见BSI B4 /IL -1RI阳性双标纤维。②致炎后第3d ,炎症组大鼠外踝关节周围皮肤及皮下组织BSI- B4阳性纤维、IL -1RI阳性纤维、IL- 1RI/BSI B4双标纤维数及双标纤维占各单标纤维的百分比较生理盐水组显著升高(P <0 .0 1 ,P <0 .0 5 )。③IL -1受体拮抗剂组大鼠BSI B4阳性纤维、IL -1RI阳性纤维、IL -1RI/BSI B4双标纤维数及双标纤维占IL- 1RI单标纤维的百分比较炎症组显著降低(P <0 .0 1 ,P <0 .0 5 )。④电针组大鼠BSI B4阳性纤维及IL- 1RI/BSI B4双标纤维数、双标纤维占IL -1RI单标纤维的百分比显著低于炎症组(P <0 .0 5 ) ,并高于IL -1受体拮抗剂组(P <0 .0 1 )。结论:正常大鼠踝关节周围皮肤及皮下组织C纤维上有IL- 1RI表达,完全弗氏佐剂导致的踝关节周围局部炎症组织中该表?Objective:To observe the effect of electroacupuncture (EA) on the number of Bandeiraea Simplicifolia I (BSI)-B4 labeled and IL-1 receptor I immunoreaction (IR) positive nerve fibers of the dermal and subcutaneous tissues around the ankle joint in adjuvant monoarthritis rats. Methods: 28 male SD rats (180～200 g) were randomized into control group, model group, IL-1 receptor antagonist (IL-1-RA) group and EA group, with 7 cases being in each group. Adjuvant monoarthritis model was induced by injection of 50 μL complete Freund's adjuvant (CFA) into the left hind ankle joint cavity. EA (4～16 Hz, 0.5～1.5 V and intermittent waves) was applied to “Huantiao”(GB 30) and “Yanglinquan”(GB 34) for 30 min following injection of CFA and on the 3rd day. In IL-1-RA group, on the 1st and 3rd day after injection of CFA, IL-1RA (1 μg/mL, 50 μL) was injected into the subcutaneous tissues around the left hind ankle joint. On the 3rd day, the rats were anesthetized with 20% urethane (1 g/kg) and transcardiac perfusion was performed by using 4% paraformaldehyde phosphate buffer (pH 7.4). The skin and subcutaneous tissues around the focus region were taken to be cut into sections (10 μm) which were then treated with BSI-B4 staining (for displaying C-fibers) and IL-1RI immuno-fluorescent labeling techniques. The number of BSI-B4/IL-1RI double labeled IR-positive nerve fibers (30 sections/rat,38.44 mm2/section) was calculated and analyzed by using fluorescent microscope and image analysis system. Results: 1) The double labeled (BSI-B4/IL-1RI/IR positive) fibers mainly distributed in the dermal and subcutaneous tissues around the ankle joint. 2) Compared with control group, BSI-B4 labeled fibers and IL-1RI/IR-positive fibers, and the double labeled fibers and the percentage of double labeled fibers/ BSI-B4 or IL-1RI single-labeled fibers in model group, IL-1-RA and EA groups were significantly higher(P<0.05～0.01); 3)In comparison with model group, the number of BSI-B4 labeled fibers, IL-1RI IR-positive fibers, double stained fibers and the percentage of double-stained fibers/IL-1RI single-stained fibers of IL-1-RA group was markedly lowered(P<0.05～0.01; 4)Compared with IL-1-RA group, the number of BSI-B4 labeled fibers, double labeled fibers and the percentage of double-labeled fibers / IL-1RI IR single-stained fibers of EA group was markedly lowered(P<0.05), and the percentage of double labeled fibers/BSI-B4 labeled fibers was significantly higher(P<0.05). Conclusion: 1) There is IL-1RI expression in the C-fibers of the dermal and subcutaneous tissues around the ankle joint in normal rats, which is upregulated in the inflammatory tissue induced by CFA. The analgesic effect of EA is probably related to its suppressive effect on C-fibers' proliferation and IL-1β(inflammation factor) induced activation of IL-1RI and its promotion effect on the synthesis of IL-1RA (the endogenous anti-inflammatory factor) in the inflammation focus.关键词：针刺镇痛;佐剂性关节炎;IL-1受体1352|0|2更新时间：2023-08-11
- 摘要：目的:研究针刺“内关”穴对心肌梗塞后缺血区微血管ATPase活性变化的干预效果。方法:采用Mg2 + ATPase光镜酶组织化学和Na+ K+ ATPase电镜酶细胞化学方法,动态显示微血管内皮细胞的ATPase活性。结果:结扎冠脉后,血管内皮细胞出现缺血缺氧性损伤,ATPase活性降低(P <0 .0 5、0 .0 1 ) ,以2d时损伤最重;1周以后ATPase活性开始恢复,3周时仍未恢复到正常水平(P <0 .0 5 )。针刺组ATPase活性损伤较模型组为轻(P <0 .0 5、0 .0 1 ) ,其ATPase活性损伤修复较快,3周时恢复到正常水平(P >0 .0 5 )。结论:针刺“内关”穴具有改善缺血区微血管内皮细胞ATPase活性的功能。关键词：急性心肌梗塞;针刺;内关穴;微血管;ATPase1112|0|3更新时间：2023-08-11
- 摘要：目的:观测针刺对STZ所导致的糖尿病大鼠下丘脑NPY及其mRNA表达的影响。方法:Wistar大鼠4 3只,1 3只为正常对照,另30只行链脲左菌素腹腔注射造模,造模成功的大鼠随机分为模型组和针刺治疗组(针刺“胰俞”“足三里”“关元”) ,针刺治疗2个疗程后取脑,运用免疫组化法和原位杂交法分别检测下丘脑NPY蛋白及其mRNA的表达。结果:STZ糖尿病大鼠下丘脑室旁核、弓状核NPY阳性纤维较正常组大鼠明显增多,下丘脑外侧区NPYmRNA表达较正常明显增多(P <0 .0 5 ) ,针刺治疗后糖尿病大鼠下丘脑室旁核、弓状核NPY阳性纤维及下丘脑外侧区NPYmRNA表达明显减少(P <0 .0 5 )。结论:针刺可以降低STZ糖尿病大鼠下丘脑增多的NPY的合成及其含量,这可能是针刺改善糖尿病能量代谢的中枢机制之一。关键词：糖尿病/针刺疗法;神经肽Y;基因表达;下丘脑1091|0|3更新时间：2023-08-11
- 摘要：目的:探讨电针抗抑郁研究适宜模型的选择。方法:选用药物实验方法,观察去甲肾上腺素毒性实验小鼠的死亡率、5 羟色胺酸甩头实验小鼠甩头次数。用改变环境条件的方法,观察悬尾实验小鼠悬尾的不动时间和通过慢性应激模型观察开野实验大鼠的活动性及检测糖水实验糖水的摄入量。结果:与空白对照组相比,电针不能降低去甲肾上腺素毒性实验小鼠的死亡率,不能减少5 羟色胺酸甩头实验小鼠的甩头次数;但能减少悬尾实验小鼠悬尾的不动时间;慢性应激模型中,与模型组及模型束缚组相比,电针组和百优解组可明显增加开野实验的垂直运动次数及糖水的摄入量。结论:针刺对抑郁症的实验研究应选择改变环境条件诱发的抑郁动物模型进行,药物诱发的抑郁模型可能是不适宜的。关键词：抑郁;慢性应激;电针;动物模型1012|0|17更新时间：2023-08-11
- 摘要：目的:探讨采用针刺的方法对AD大鼠认知行为及脑内超氧化物歧化酶(SOD)活性的影响。方法:选用纯系健康雄性Wistar大鼠4 8只,随机分为假手术组、模型组、针刺组和西药组。采用β- 淀粉样蛋白向海马CA1区定向注射制作AD模型。采用针刺“百会”“四神聪”穴进行治疗。检测大鼠的穿梭箱实验成绩和脑组织内SOD的活性。结果:针刺模型大鼠的“百会”“四神聪”穴可以减少其在穿梭箱实验中的电击次数和电击时间,提高脑组织内SOD活性。结论:采用针刺的方法可明显改善AD大鼠的学习记忆能力,并能提高其脑内SOD的活性。关键词：针刺疗法;痴呆/老年性;认知行为;超氧化物歧化酶1110|0|4更新时间：2023-08-11
-
- 摘要：目的:观察不同时辰电针对大鼠脊神经节和脊髓内生长抑素(SOM )mRNA阳性神经元表达的影响。方法:将2 0只SD大鼠随机分为电针组和对照组,每组又各分为4个时段。采用原位杂交组织化学方法,观察5时、1 1时、1 7时和2 3时2Hz电针大鼠一侧“环跳”穴后,脊神经节和脊髓内SOMmRNA阳性神经元表达。结果:电针大鼠一侧“环跳”穴后,1 1时电针组脊神经节和脊髓后角第Ⅰ、Ⅱ板层SOMmRNA表达增强(P <0 .0 5 )。结论:1 1时2Hz电针对大鼠脊髓和脊神经节内SOMmRNA阳性神经元的表达有上调作用。关键词：电针;脊神经节;脊髓;SOMmRNA表达1114|0|4更新时间：2023-08-11
- 摘要：目的:探讨穴位贴敷治疗慢性萎缩性胃炎的作用机理,为临床应用提供科学依据。方法:采用长期喂养0 .0 2 %的氨水诱发大鼠慢性萎缩性胃炎为动物模型,选取“足三里”“中脘”穴进行穴位贴敷治疗,与口服胃苏冲剂进行对照,观察穴位贴敷对慢性萎缩性胃炎大鼠一般状态及体重、胃黏膜血流量、胃黏膜前列腺素E2 的影响。结果:穴位贴敷可以改善大鼠一般状态及体重,增加胃黏膜血流量及胃黏膜前列腺素E2 ,其作用优于药物对照组。结论:穴位贴敷对胃黏膜确有保护作用,是临床治疗慢性萎缩性胃炎的有效方法之一。关键词：慢性胃炎/萎缩性;穴位贴敷;胃黏膜血流量;胃黏膜前列腺素E21028|0|3更新时间：2023-08-11
- 摘要：目的:探讨电针足阳明经“四白”穴和胃扩张刺激诱导大鼠孤束核(NTS)的原癌基因c -fos表达及意义。方法:将SD大鼠随机分为4组:电针“四白”穴组、电针“四白”穴旁开0 .5cm组、胃扩张模型组和空白对照组。采用免疫组织化学方法观察c- fos在孤束核的表达。结果:电针“四白”穴组和胃扩张模型组孤束核内Fos样免疫反应(FLI)阳性神经元均主要分布于内侧亚核,以延髓的中尾段分布较多;电针“四白”穴组在内侧亚核内FLI神经元数目与胃扩张模型组比较无明显差异(P >0 .0 5 ) ,与“四白”穴旁开组比较,差异有非常显著性意义(P <0 .0 1 )。结论:电针“四白”穴和胃扩张刺激的感觉传入可能在孤束核发生汇聚、整合,是针刺“四白”穴调节胃功能的中枢途径之一。关键词：c-fos基因表达;电针;“四白”;胃扩张;孤束核1122|0|4更新时间：2023-08-11
- 摘要：目的:研究针刺申脉穴脑功能变化的规律和激活脑区的定位信息。方法:利用血氧依赖性磁共振成像技术,获得健康志愿者的申脉穴在行针及留针不同针刺状态下的脑功能变化图像,利用SPM信号处理系统,对比分析不同针刺状态下脑功能变化的规律。结果:针刺申脉穴主要激活边缘系统(丘脑、扣带回、海马旁回)和额叶、颞叶等脑区,在行针和留针过程中激活的脑区存在较为明显的规律性变化,在行针过程中首先激活对侧脑区,留针后逐渐由对侧延伸到双侧。结论:激活的脑区可能在申脉穴治疗失眠等心境障碍性疾病时起一定作用。关键词：针刺;申脉;fMRI;脑功能成像773|0|8更新时间：2023-08-11
- 摘要：目的:探寻治疗颈性眩晕症的有效治疗方法。方法:临床随机分为针刺组6 4例,药物组5 0例。针刺组采用透刺法为主,脑空透风池、玉枕透天柱、丝竹空透率谷、颔厌透悬颅。药物组采用静滴丹参注射液、口服西比灵。治疗3个疗程后进行疗效比较。结果:针刺组总有效率为92 .1 8%,药物组总有效率为78.0 0 %。经统计学处理,两组疗效差异有显著性意义(P <0 .0 5 )。结论:透刺法为主治疗效果优于药物疗法,是一种安全有效、经济实用的方法。关键词：椎基底动脉供血不足;针灸疗法;透针1003|0|0更新时间：2023-08-11
- 摘要：目的:比较针刺与药物治疗稳定性心绞痛的疗效差异。方法:随机选取稳定性心绞痛患者,分为针刺组30例、药物组2 2例,分别比较治疗后两组症状、心电图及硝酸甘油停减情况。结果:症状疗效方面:针刺组有效率为90 .0 0 %,药物组有效率为81 .82 %,两组比较有显著性差异(P <0 .0 5 )。心电图改善情况两组未见明显差异。硝酸甘油停减情况:针刺组停药率为2 3.3%,药物组停药率为1 8.2 %,两组比较无明显差异。结论:针刺具有明显改善稳定性心绞痛症状的功效。关键词：稳定性心绞痛;针刺;药物890|0|4更新时间：2023-08-11
- 摘要：本文提出古代针灸文献中症候群的概念及鉴别的方法和手段(软件和数据库)问题,将传统文献方法研究的结果进行多角度、多层次和量化的分析和处理,探索计算机在症候群鉴别研究中的方法意义和应用策略,作为实现针灸文献中的疾病、证候与症状计算机统计的初步尝试。本文研究的意义主要表现在研究思路和方法学上,将方法学的创新与新方法的示范应用有机地结合起来,对于解决针灸学术中经络学说、腧穴学、治疗学的相关问题有着一定的价值。关键词：针灸学;文献研究;症候群/症状1005|0|0更新时间：2023-08-11
- 摘要：本文系统总结了近1 0年来有关电针治疗抑郁症的临床报道和实验研究文献,将电针与西药、中药、毫针之间的疗效进行了比较,并从机理上探讨了电针对免疫功能、甲状腺激素、大脑葡萄糖代谢、单胺类神经递质、HPA轴、BDNF和信号传导通路的影响,为进一步研究提供了思路和途径。关键词：抑郁症;电针;综述1100|0|7更新时间：2023-08-11
- 摘要：本文从神经机制的调节、胃肠激素、胃粘膜血流量、体液因子、氧自由基、胃壁屏障等方面阐释了针灸对胃粘膜损伤保护作用的可能机理,提出了目前针灸在该领域研究存在的问题及解决办法。关键词：胃粘膜损伤;针灸;保护机制;综述1125|0|5更新时间：2023-08-11
- 地址：北京市东城区东直门内南小街16号 邮编：100700
- 联系电话：010-64089344,84014607 Email：zcyjbjb@vip.163.com
- 技术支持由北京北大方正电子有限公司提供 京ICP备05017590号-8
京公网安备11010802020460号 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
0