摘要:目的:对比先“合谷”后“三阴交”穴不同的电针刺激时间组合对大鼠怀孕后期子宫收缩的影响。方法:选健康成年雌性Wistar大鼠60只,应用2×2析因试验设计方法,分为4个电针组(以针“合谷”穴20 min或40 min与加针“三阴交”穴5 min或20 min组合)、正常对照组及模型对照组。电针的同一对正负极连接双侧同名穴,簇形波,频率20 Hz,强度13.5 V。于子宫中段安放电极,通过肌肉张力换能器记录子宫收缩幅度、频率,作为判断宫缩变化的指标。结果:先针“合谷”穴、次针“三阴交”穴后,二穴共同留针时间的长短对子宫收缩的影响更为重要,留针5 min较20 min更能促进子宫收缩。而单独先针“合谷”穴期间留针20 min或40 min对子宫收缩影响不大。结论:针刺“合谷-三阴交”穴促分娩的最佳时间组合是先针刺“合谷”穴20 min,再加针“三阴交”穴5 min。Objective:To study the effect of electroacupuncture(EA) at "Hegu"(LI 4) with different stimulation duration in combination with needle retention in "Sanyinjiao"(SP 6) for different duration on uterine contraction in late-stage pregnant rats.Methods: A total of 50 late-stage pregnant(193.5 V。于子宫中段安放电极,通过肌肉张力换能器记录子宫收缩幅度、频率,作为判断宫缩变化的指标。结果:先针“合谷”穴、次针“三阴交”穴后,二穴共同留针时间的长短对子宫收缩的影响更为重要,留针5 min较20 min更能促进子宫收缩。而单独先针“合谷”穴期间留针20 min或40 min对子宫收缩影响不大。结论:针刺“合谷-三阴交”穴促分娩的最佳时间组合是先针刺“合谷”穴20 min,再加针“三阴交”穴5 min。
摘要:目的:观察针灸治疗类风湿性关节炎(RA)的疗效,并与西药甲氨蝶呤(MTX)的作用进行对比。方法:90例RA患者分为针灸治疗组45例,附子饼间接灸大椎、命门、肝俞、脾俞、肾俞,局部取穴温针灸受累关节,隔日1次;甲氨蝶呤对照组45例,肌注MTX 10 mg,每周1次。两组疗程均为5个月,观察项目有治疗前后的关节痛程度、晨僵、握力、血沉(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)及临床总体疗效、起效时间和不良反应。结果:针灸组的关节痛程度、晨僵、握力、ESR、CRP、RF等指标改善情况明显优于MTX对照组(P<0.05)。针灸组显效13例,有效17例,改善9例,无效6例,总有效率86.7%;MTX组显效12例,有效14例,改善8例,无效11例,总有效率75.6%;两组相比有显著性差异(P<0.05)。起效时间针灸组较MTX组明显缩短(P<0.05),且针灸组未见明显不良反应。结论:针灸治疗类风湿性关节炎优于甲氨蝶呤。Objective: To observe the therapeutic effect of acu-moxibustion in the treatment of rheumatoid arthritis.Methods: A total of 90 cases of rheumatoid arthritis patients were divided into acu-moxibustion group(n=45) and medication group(n=45) according to random number table method.For patients of acu-moxibustion group,Fuzi(附子Radix Aconiti Praeparata) cake-separated moxibustion was applied to bilateral Dazhui(GV 14),Mingmen(GV 4),Ganshu(BL 18),Pishu(BL 20) and Shenshu (BL 23).Acupoints around the affected joints were punctured with filiform needles which were twirled,lifted and thrust repeatedly for a while followed by attaching ignited moxa cones to the handle of the needle(30 min).The treatment was given once every other day,with 1 month being a therapeutic course,5 months altogether.The patients of medication group were treated by intramuscular injection of Methotrexate((10 mg)),once every week,5 months altogether.Joint pain degree,morning stiffness duration,grip strength,erythrocyte sedimentation rate(ESR),and serum C-reactive protein(CRP) and rheumatoid factor(RF) were detected before and every month after the treatment.The total therapeutic effect was judged by using the improved degrees of ESR and CRP [(values before treatment-those after treatment)/(values before treatment-normal value)] ×100%.Results: Before the treatment,there were no significant differences between two groups in joint pain degree,morning stiffness duration,grip strength,ESR,CRP and RF values,while after the treatment,self-comparison showed that the pain degree,morning stiffness duration,ESR,CRP and RF decreased significantly,while the grip strength increased remarkably in both groups(P<0.05).Comparison between two groups indicated that the therapeutic effect of acu-moxibustion group was significantly superior to that of medication group in these 6 indexes(P<0.05).Results of the total therapeutic effect revealed that of the two 45 cases in acu-moxibustion and medication groups,13(28.9%) and 12(26.7%) experienced significant improvement,17(37.8%) and 14(31.1%) had a moderate improvement,9(20.0%) and 8(17.8%) had mild improvement,6(13.3%) and 11(24.4%) failed,with the total effective rates being 86.7% and 75.6% respectively.In addition,the time for inducing therapeutic effect was significantly earlier than that of medication group(P<0.05).Conclusion: Acu-moxibustion is effective in the treatment of rheumatoid arthritis and its therapeutic effect is markedly superior to that of Methotrexate.