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甘肃中医药大学针灸推拿学院,甘肃 兰州,730000
Received:07 September 2025,
Revised:2025-11-25,
Online First:27 February 2026,
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梁璐,李笑笑,杜小艳,等.基于氧化应激探讨针刺干预抑郁症的机制研究进展[J].针刺研究,XXXX,XX(XX):1-7.
LIANG Lu,LI Xiao-xiao,DU Xiao-yan,et al.Research progress on the mechanism of acupuncture intervention for depression based on oxidative stress[J].Acupuncture Research,
梁璐,李笑笑,杜小艳,等.基于氧化应激探讨针刺干预抑郁症的机制研究进展[J].针刺研究,XXXX,XX(XX):1-7. DOI: 10.13702/j.1000-0607.20250928.
LIANG Lu,LI Xiao-xiao,DU Xiao-yan,et al.Research progress on the mechanism of acupuncture intervention for depression based on oxidative stress[J].Acupuncture Research, DOI:10.13702/j.1000⁃0607.20250928.
抑郁症是一种慢性复发性精神疾病,具有患病率高、发作时间长、复发率高和致残率高等特点。针刺治疗该病疗效肯定,其机制研究日益深入。抑郁症发病与氧化应激密切相关,本文从氧化应激角度总结了针刺干预抑郁症的机制,包括调控氧化应激相关通路表达,抑制铁死亡,调节氧化应激-Calpain-炎性反应信号轴,降低cGMP含量,减少线粒体凋亡,从而减少氧化应激产物,提高抗氧化能力,改善机体氧化损伤和抑郁症状。
Depression is a chronic and recurrent mental disorder characterized by high prevalence, prolonged episodes, high recurrence rate, and significant disability. Acupuncture has been shown to be effective in treating this condition, and its underlying mechanisms are increasingly being investigated. The pathogenesis of depression is closely associated with oxidative stress. This review summarized the mechanisms of acupuncture intervention in depression from the perspective of oxidative stress, including the regulation of oxidative stress-related signaling pathways, inhibition of ferroptosis, modulation of the oxidative stress-Calpain-inflammatory signal axis, reduction of cGMP content, and attenuation of mitochondrial apoptosis. These actions collectively contribute to the reduction of oxidative stress products, enhancement of antioxidant capacity, and improvement of oxidative damage and depressive symptoms.
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