最新刊期
卷 ， 期 1 ， 1993
- 摘要：This article reviews the main results in resent years of studies on the roleof central Ach in pain modulation and analgesia,including.(1) cholinergicallyinduced analgesia (CIA).Cholinomimetic drugs raised the pain threshold orinhibited the unit discharges of hypothalamus parafascicularis nuclens in rats,and these actions were revesed by atropine not by nicotine.(2) Ach and acu-puncture analgesia (AA).The effect of electroacupuncture was changed byadministration of HC-3,atropine,etc.(3) Ach and stress analgesia (SA).Scopolamine reduced the hind foot shock induced analgesia,and this kind of SAwas probably mediated by m-receptors existed at supraspinal,rather than spinallevel.Swimming and immobilization analgesia were also related to Ach.Thesedata suggested that the central cholinergic system is very important in painmodulation and analgesia and the cenatral Ach is essential transmitter or modu-lator in this analgesic pathway.But the problem is whether the mechanism ofCIA is involvtd in opiate analgesic system or not.1003|0|1更新时间：2023-08-11
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- 摘要：Occluding unilateral middle cerebrarl artery (MCAo) of rat,the compensatoryblood vessels (CBV) within ischemic area in cerebral surface shown by cerebralperfusion and effect of acupuncture were observed dynamically.Perfusing im-mediately after MCAo,there was no any blood vessel in the ischemic area.Inacupuncture group,the CBV had extended a lot from anastomotic network ofcerebral pin mater (ACA-MCA,PCA-MCA) located in marginal zone of ischemicarea 3 hs after MCAo.6,24 and 48 hs after MCAo,the CBV increased muchmore than control group (non-acupuncture) P<0.01.The experiment pointed outthat there existed a serious vasospasm in the MCA system in initial stage ofMCAo,which led up to decompensation in the ischemic area.The acupuncturecan remit the vasospasm,and reverse the deteriorated process in early.1725|0|15更新时间：2023-08-11
- 摘要：In this experiment,three groups were used to detect c-fos expression in theCNS in the awake male,S.D.rats,i.e,EA of “Ouanliao” (14Hz),electrostimu-lation of the rat tail (0.4-0.6mA) and the control.Fos was identified by ABCimmunohistochemical method.The results were as follows:Ⅰ.The labelling cell-ular nuclei of pain group are in the laminae Ⅰ,Ⅲ,Ⅴ,Ⅶ,and Ⅹ of the spinal cordthe medial part of the frontal cortex (FC) and that of the EA group wrer inthe trigeminal nucleus and the lateral area of the FC.The number of thelabelling nuclei (n) of EA group war more than that of the pain group in therostral ventromedical medulla,the lateral reticular,the solitary n.the popiaqu-eductal grey,the parafacicular n,the centromedian n.and the subparafascicularn,of the thalamus.2.The labelling nuclei of EA and pain groups appear commonly in thedorsal raphe n.,the locus ceruleus,the periventricular n.of the thalamus,the hypothalamue,the lateral habenu-lar n.,and the sepatal area.In the control animals,in general,the labelled nucleiwere sparsely seen.1028|0|1更新时间：2023-08-11
- 摘要：The pain components of somatosensory evoked potentials (SEPs) of induced bymedian nerve stimulation were studied with the way of blocking bloodstreamof arm in 12 normal adults.The SEPs following the painful stimuli (0.1msec.square wave pulse) of the right wrist were recorded from the left parietal(C3′) and frontal (F3) scalp with earlob reference electrode.The pressure of40 mmHg above the arterial pressure was given to the right upper arm bysphygmomanometer.The resnlt showed that the P200-N300 components (latency234±13 msec.and 308±23 msec.) of the SEPs persisted and the others disapp-eared when tactile sensation disappeared but pain existed.The morphology ofP200-N300 from F3 was same to that from C3′.It suggested the P200-N300were the pain potentials of median nerve SEPs.1045|0|3更新时间：2023-08-11
- 摘要：In this work the visual,auditory,somatosensory evoked cortical potentialsas well as raw EEGs were observed in 31 rabbits either anesthetized with ure-thane or conscious.The effects of acupuncture on them were as follows:1)The main compon(?)nts of the evoked potentials were significantly depressed;2)The raw EEGs were desynchronized while the animals appeared to be slightlyactivated;3) Both the integral values of raw EEGs and the powers of lowerfrepuency waves (1-3.99Hz) were decreased and positively correlated well withthe amplitudes of the main components of the evoked potentials.Therefore,Itcould not be ruled out that the effects of acupuncture on the evoked potentialsare secondary to the changes of EEGs,and it is suggested that the inhibition ofevoked potentials during acupuncture does not necessarily mean that the cerebralcortex is in an inhibitory state.911|0|6更新时间：2023-08-11
- 摘要：The experiment was to study whether the effects of electroacupuncture (EA)on neurons in nucleus raphe magnus (NRM)were influenced after lesion of bila- teral pyramidal tracts (PT) in the rats.unit discharges of NRM were recordedextracellularly with glass microelectrodes,and their nociceptive responses wereinduced by train electro-stimulation of tail.It was researched only the neuronswith excitory response to noxious stimulation of the tail.1.The effects of bilateral ‘Zusanli’ acupoint on 31 NRM neurons wereobserved in control group.EA had a tendency to activate NRM neurons,butinhibited obviosly nociceptive response of the neurons at 0-30 minutes (P<0.01).The effects of EA of PT control group (PT exposed and kept intact) wererecorded on 8 units in NRM.EA had a tendency to activate the neurons,butinhibited obviously nociceptive response of the neurons and decreased nocice-ptive response rate 25.3±8.7% at o minte (n=8,P<0.05)3.EA after the PT lesion,it obviously inhibited nociceptive response ofthe neurons in NRM at 0-20 minutes (n=9,P<0.01-0.05).It inhibited noci-ceptive ressponse of all the neurons and decreased noeiceptive response rate57.8±11.6% at o minute (P<0.01).The effect was larger than the effect ofEA of PT control group and increased 32.5% at o minute (P<0.05) than this.It also increased the effect of EA activating the neurons than PT control group.The results suggest that SM may influence th effect of EA analgesia,whichinvolves in both PT and extrapyramidal system (EPS).The PT may decreasethe effect of EA,but the EPS may increase the effect of EA.1002|0|2更新时间：2023-08-11
- 摘要：The aim of the present work is to observe the effects of somatosensory areaⅡ(Sm ) on the descending inhibiting pain activity of nucleus raphe magnus(NRM).The unit discharges in NRM and its responses to noxious stimulationof tail tip were extracellularly recorded with glass microelectrode.The bilateralSm(?) was stimulated by fixed electrodes.Electroacupuncture (EA) of “Zu-sanli” was applied for 5 minutes.Both effects were compared at the same NRMneurons.It was found that stimulation of Sm(?) could activate the excitatoy-neurons in NRM (n=10),significantly increasing their spontaneous discharges and decreasing their nociceptive responses during 0-20 minutes (P<0.05-0.001).Si-milar results were observed after “Zusanli” EA,increase of their spontaneousdischarges during 0-10 minutes and at 20th minute,and decrease of their nocice-ptive responses during 0-25 minutes were statistically significant (P<0.05-0.001).The results were analysed with the linear regression,it was shown that theeffects of Sm(?) stimulation and “Zusanli” EA on the spontaneous discharges andtheir nociceptive responses of NRM neurons were very similar in level and trend,being the positive correlation (P<0.01-0.001).It is suggested that Sm(?) canactivate the excitatory neurons in NRM,and it is possible that the effect of EAof “Zusanli” on NRM neurons is partially caused by activating Sm (?).982|0|0更新时间：2023-08-11
- 摘要：We took the unit discharges of the neurons in the posterior group of thala-mic nuclei (PO) caused by stimulating the great splanchnic nerve (GSN) as anindicator of visceral pain.We searched for the effects of eletrical stimulatingcentral nucleus of amygda(?)a (AC),lateral nucleus of amygdala (AL),bed nucle-us of striae terminalis (BNST) and lateral area of hypothamus (AHL) on unitdischarges of PO and the relationship among these nucleuses.The result indicated that the inhibitory effects were strongest with stimula-ting AC,the next was with stimulating AHL,then BNST and AL.The inhibi-tory percentages were 85.7%(AC),62.9%(AHL),53.1% (BNST) and 54.2%(AL) respectively.The inhibitory effects of stimulating AC couldn't be cance-led by injecting naloxone intravenously.AC may be more important for theantinociceptive system than AL,BNST and AHL.There was no relationshipbetween AC and BNST on the inhibition of unit discharges.The inhibitoryeffects of stimulating AL may be related to AC.1060|0|0更新时间：2023-08-11
- 摘要：In the present paper,transient effects and after-effects of electroacupunctureanalgesia at the low frepuency and low intensity (10 Hz,3V),high frequencyand low intensity (200 Hz,3V),low frepuency and high intensity (10 Hz,6V) aswell as high frepuency and high intensity (200 Hz,6V) were observed in rats.The results show that the transient analgesic effect of the low frepueney EA isstronger than that of the high frepuency EA and the strong EA is greater thanthe weak EA.However,the high frepuency EA is superior in the after-effectof analgesia to the low frepuency EA and the weak EA is to the strong EA.1092|0|16更新时间：2023-08-11
- 摘要：It has been demonstrated that electroacupuncture (EA) produces analgesiain acute arthritic animal models,while the differential analgesic effects at dif-ferent EA parameters remains to be discovered.In the present experiment,theeffects of EA at 100 Hz and 15 Hz on bilateral Yanglingpuan acupoints of thearthritic rats was studied.The results showed:1) 15Hz EA was more effectivethan 10Hz EA for analgesia;2) spinal glutamic acid content of the 15-Hz EAgroup was significantly lower than that of the 100-Hz EA group,and 3) nosignificant difference in GABA contents between the two groups was found.The results suggest that spinal glutamic acid may be involved in the differentanalgesic effects of EA at different frequencies in arthritic rats.1081|0|5更新时间：2023-08-11
- 摘要：Experiments were performed in 57 SD rats.The stress was induced by bi-nding plus revolving (5.5xg,170c/min,10min) or cold (0～4℃,30～60min).Selected acupuncture points were “Zusanli” and “Weishu”.Bipolar Ag-AgClrecording electrodes were respectively implanted on the serous membrane surfaceof the antrum,duodenum and on the abdominal skin corresponding to aboveareas.The results were as follows:(1) There are 63.2% individuals in thestress group which showed a large quantity of bleeding points spreading over thegastroduodenal mucosal membrane.The area density of lesion was 15.8～27.7%.Under microscope the signs emerged including mucosal blood vessel dilatationand hyperaemia,gland cell swelling,vi(?)lus broken and peeling off and lymph cellaccumulating,etc.84% individuals showed obvious inhibition of gastroduodenalelectroactivities including that the amplitude of slow wave was lower,the frequ-ency decreased even the rhythm was disordered,the number of fast wave redu-ced and the IDMEC (?) cycle was prolonged.(2)In the group of acupunctureplus stress only 16.7% individuals showed bleeding or hyperaemia,and the lesionarea density was only 1.7%.Also the pathohistological changes were obviouslydecreased.Gastroduodenal electrical changes were hardly seen (27.2%) or theinhibitory state above were significanly reduced (54.5%) when compared withthe stress group.There is strong reason to consider that acupuncture couldeffectively reduce the mucosal lesion and the electrical inhibition of stomachand duodenum induced by stress in rats.942|0|2更新时间：2023-08-11
- 摘要：After intraperitoneal injection of ACTH,the content of GABA in hippoca-mpus and the pain threshold were increased.This effect could be decreasedby cycrosporin.ACTH decreased SI of MSBT and production of IL-Ⅱ,andthis suppression could be reversed by GABA synthesis inhibitor isoniazid,orGABA receptor blocker picrotoxin.These results suggest that:the analgesiceffect of ACTH is related with the increase of GABA content in hippocampus,and cell immunity could be involved the regulation of GABA content in thebrain regions.ACTH inhibited the effect of cell immunity,and this effect rela-ted to GABA content.Above effect is at least partly mediated by GABAsynthesis and GABA receptor.1043|0|2更新时间：2023-08-11
- 摘要：Identified tract cells in lumbar enlargement were recorded from intact ana-esthetized rats.The prolongation of the latency of antidromic action potentialwas a measure of postsynaptic inhibitipn.Both ST 36 and SP 6 were stimulatedelectrically.In EA group (N=12) EA prolonged the latency for 0.111±0.022ms(P<0.001).In bicuculline group (N=12) the prolongation of the latency for0.010±0.004ms (P<0.05) by EA was less than that of EA group with stati-stical significance.In naloxone group (N=12) and SP antiserum group (N=12)EA did not induce a significant prolongation of the latency.It suggested thatGABA,opioides and SP might be involved in postsynaptic inhibition induced byEA.1119|0|1更新时间：2023-08-11
- 摘要：Experiments were done with male rabbits (2.5-3.0Kg).The postganglionicfibers from bilataral pelvica ganglia to the bladder were excised partially andresulted in reversible retention urine.The pressure-volume curve of bladder andvolume of residual urine was measured at the third day,sixth day,thirteenthday,twentieth day and twenty-seventh day after the operation of denervationand compared with preoperation respectively.The rabbits were divided into twogroups at random,In electroacupuncture group,immediately after the operationof denervation,the intradermal needles were implanted in derma of bilateral“Subcortex” auriculopoint.Before each measurement electroacupuncture at thesepoints and bilateral “Shenshu” (somatic point) was given for 10 minutes.Incontrol group,the operation of denervation was undergone as well but did notbe implanted the needle and given electroacupuncture.The results showed that,before the operation a smooth or slowly uniform rising wave appeared on thepressure-volume curve of bladder and only a peak repeated on this backgroundat an instant every injecting water.But after the operation,due to losing ofcontrol of parasympathetic nerve partially the pressure-volume curve of bladderappeared ascending step wave evidently after every injecting water.The bladdervolume and the residual urine increased evidently.The differences between beforeand after the operation were statistically significant (P<0.05).It showed that,after denervating partially the adaptation of the rabbits' bladder was decreased.But on the third day and the sixth day after operation the residual urine decre-ased more evident in electroacupuncture group than in control group (P<0.05).The extent of change of pressure-volume curve was lesser,the recovery of thebladder volume and the urination pressure was faster than that of control group.It showed the regulation function of electroacupuncture.996|0|1更新时间：2023-08-11
- 摘要：After stimulating the auricular liver-gall point of rabbit with electrode.We observed marked contraction of gallbladder.Only one minute after stimu-lation,the contraction began.About ten minutes fter stimulation the contra-ction was marked and the contraction lasted for 30—40 minutes.The averageproduct of the length and width of gallbladder (15—25.minutes after stimula-tion) is markedly smaller than that of control (pre-stimulation).This resultproves the liver-gall point of rabbit corresponds with its internal organ-gallbla-dder.The result also present a theoretic basis for clinical therapy of pressover the auricular liver-gall point induced the excretion of gallstones.713|0|0更新时间：2023-08-11
- 摘要：Twinty-nine rabbits were used.The spindle,tendon organ,light and hea-vy pressure receptors in medial gastrocnemius muscle were identified by reco-rding discharges of single afferent fiber in medial gastrocne mius nerve fromfine filaments by dissection.The discharge patterns of the receptors respon-ding to the manipulations,i.c.lift and thrunst,twist and twirl,rotate,scra-pe flick the needle and finger-pressure were observed.Data at 85 units werecollected totally.Every type of deep receptor can react to any manipulation.The dischargepatterns of different receptors were alike when stimulated with same manipu-lation,but there were different patterns while varying manipulations actingon the same receptor.These are due to the movement forms,the force amo-unt,the time duration of the manipulations.All these facts are nearly thesame as in cutaneous receptors.Acupuncture effect on deep receptors was not limited to one point butwithin a certain area,namely distant effect existed.The area size variedfrom receptor to receptor and from manipulation to manipulation.Because of the distant effect on receptors by acupuncture,and the loseof responsibility in units when receptor destroyed,we suggest that effectiveacupuncture stimulation is induced mainly due to the receptor deformation,whichis caused by the stress from pressure,stretch and vibration of acupuncture.In view of the needling sensation is closely related to the curativeeffects,the receptors dealing with needling sensation are analysed according tothis series works and other facts,we further advance the opinion that the re-ceptors of deep pain are the chief material foundation to induce the sensationof hand needling.718|0|1更新时间：2023-08-11
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