最新刊期
卷 ， 期 1 ， 1994
- 摘要：This work was to study the influence of lesion of Sm Ⅱ on effects of electroacupuncture (EA) upon nucleus raphe magnus (NRM).The experiments were performed on rats. The unit discharges of NRM neurons and their responses to noxious stimulation on tail tip were recorded extracellularly with glass microelectrode.The excitatory neurons of NRM were chosen and divided into two groups, one of them(n=10)was control before lesion of bilateral Sm Ⅱ and another (n=17) after lesion, two neurons of this group were also observed before lesion. It was found that the neurons in the contral group before lesion of sm Ⅱ could be activated by EA of "Zusanli", the increase of spontaneous diacharges in 0-10 minutes and the 20th minute, and the decrease of their nociceptive responses in 0-25 minutes were statistically significant (P<0. 05-0. 001).But in the group after lesion the neurons were not obviously activated by EA of "Zusanli". The difference of the spontaneous discharges between the two group was statistically significant in 0-10 minutes (P<0.05-0.001), the nociceptive reponses in 0-10 minutes and at the 20th minute (P<0. 05-0.001).The results show that integrity of Sm Ⅱ is important to acupuncture analgesia, and further suggest that information from EA of "Zusanli" could arrive at Sm Ⅱ at least partially, and then activate NRM inducing analgesia975|0|0更新时间：2023-08-11
- 摘要：Effects of electrical stimulation of the somatosensory area Ⅱ (S Ⅱ) of the cerebral cortex and electroacupuncture (EA) on contents of r-aminobutyric acid (GABA), glutamic acid (Glu), aspartic acid(Asp)and alanine (Ala) in the precruciate cortex (PreCtx) were investigated in order to probe if the free amino acids in the preCtx are invohied in the S Ⅱ descending modulation and acupuncture analgesia.Adult cats were randomly divided into four groups: control, EA, electrical stimulation of S Ⅱ and stimulation of S Ⅱ plus EA. EA was applied at right Huantiao and Yanglingquan acupoints for 30 min and electrical stimulation was given on the S Ⅱ surface. Amino acids were separated by paper chromatography and determined with spectrophotometry.Results showed that the stimulation of S Ⅱ or/and EA had no significant effects on the contents of GABA, Glu, Asp and Ala in the PreCtx, indicating that the four amino acids are probably not involved in regulatory effects of EA and the stimulation of S Ⅱ on the PreCtx979|0|0更新时间：2023-08-11
- 摘要：The present experiments were designed to study the effect of glutamate on cortical somatosensory area Ⅱ (S Ⅱ) producing descending modulation of intralaminar nuclei (ILN) via the motor cortex (MCtx) in acupuncture analgesia. The glutamate antagonist glutamate diethylester (GDEE) or saline was topically applied at MCtx in 17 cats. Single unit activities of ILN neurons were extracellularly recorded. The results were as follows:1. The nociceptive responses of ILN neurons were attenuated by stimulating S Ⅱ after topical administration of saline at MCtx. However, The inhibitory effect of stimulating S Ⅱ in the same neurons was reduced after application of GDEE. There was a significant difference at 0′ - 1′ after the stimulation between the two groups (n = 10, P<0. 05).2. The inhibitory effect of electroacupuncture (EA) on nociceptive responses was reduced after topical application of GDEE, while marked inhibition was shown at 0′- 10′ after cessation of EA in the saline control group (n=11, P<0. 05).The results, together with the finding that the majority of S Ⅱ neurons could be activated by EA, showed that glutamate released from S Ⅱ to MCtx might be involved in corticofugal modulation of ILN from S Ⅱ via MCtx in acupuncture analgesia1042|0|2更新时间：2023-08-11
- 摘要：Using the techniques of multimicropipette and iontophoresis, we observed whether ACh was involved in the cortical descending modulation of Pf neurons in rats. It was shown that the inhibition elicited by stimulation of the sensorimotor area (SmⅠ) was attenuated after microiontophretic atropine and that the nociceptive responses of Pf neurons were obviously reduced by microiontophoretic ACh.Therefore, it suggests that ACh may be considered as one of the neurotransmitters involved in the descending modulation of pain969|0|0更新时间：2023-08-11
- 摘要：Norepinephrine(NE) of the nucleus reticularis paragigantocellularis lateralis(RPGL) plays an important role in acupuncture analgesia(AA). The aim of this experiment was to investigate the role of NE in RPGL during AA at presynaptic level by using push-pull perfusion, high performance liquid chromatography with electrochemical detection (HPLC-ECD) techniques.The results indicated that pain thresholdold increased significantly after 20 min of EA, while the content of NE and its metabolite MHPG in the perfusate from the RPGL was markedly decreased. A negative correlation existed between the changes of pain threshold and the release of NE and MHPG.It is indicated that electroacupuncture (EA) is able to inhibit the release of NE from the RPGL during AA1031|0|0更新时间：2023-08-11
- 摘要：In order to observe the influence of electroacupuncturing (EA)"Ren Zhong" point on acute ischemia injury in brain, an experimental model of acute ischemia injury in brain was produced by antidromically blocking double common carotid arteries in 18 rabbits. The basic arteries'pressure will be increased by EA, RA and the contents of AⅠ, A Ⅱ increased and the content of LA reduced obviously in brain. An experimental evidence was given for the safety of EA anesthesia and the curative effect of EA on ischemia in brain1559|0|5更新时间：2023-08-11
- 摘要：In the model of gerbil of acute global ischemia and reperfusion, we studied the effects of electroacupuncture (EA) on total power of EEG at different periods of global ischemia and reperfusion. The "Fengfu" (GV 16) and "Jinsuo" (GV 8) points were stimulated by electrical pulse with frequency 7 Hz and intensity of 5-6 mA for 30 min. Recording was made before ischemia and 0 min, 15min,30min, 60min, 120 min and 240 min after reperfusion respetively. The results were as follows:1. In hte control group, after 10 min of ischemia, the amplitude of EEG was severely inhibited,even became flatten, and the total power of EEG was significantly decreased to 1. 41 + 1. 29% .After reperfusion, the recovery of total power was very slow. The peak level of recovery occured at 120 min following reperfusion was 27. 39+ 11. 31%.2. In comparison with the control group, the EA remarkably improved the recovery of EEG after ischemia and reperfusion. The recovery of total power was 71. 45 + 16. 46% (P<0. 01), and 75. 27+ 18. 43 % (P<0. 01) at 120 min and 240 min after reperfusion respectively.These results strongly indicte that EA could reduce the EEG inhibition during global ischemia and improve the recovery after reperfusion1561|0|5更新时间：2023-08-11
- 摘要：5-HT and muscarine (M) recepters total binding capacities (Rt) in different brain areas and spleen were determined using recepter radioligand binding assay (RLBA) after needling zusanli of rats. And the rats without needling and needling Taichong point were used as contral. These results showed that 5-HT and M recepters Rt were decreased obviously than control group in rat's cerebral cortex, hippocampus, striatum, spinal cord and spleen when needling zusanli can produce obivous acupuncture analgesia. 5-HT Rt in briain stem and medulln oblongata was obviously decreased and not changed in thalamus. M receptor Rt value was not changed clearly in brain stem and medulla oblongata as well, but it was obviously decreased in thelamus. These results showed that effects of acupoints on Various meridians are different, thus the results of acupuncture at Zusanli are distinct from taichong1068|0|3更新时间：2023-08-11
- 摘要：The electrical activity of the dorsal horn (DH) neurons was recorded extracellularly by glass micro-pipettes in urethane-chloralose anesthetized rabbits to analyze the role of the thoracic segments (T2-T3) of the spinal cord in the integration of information from electroacupuncture (EA) at Neiguan (PC 6) and acute myocardial ischemia(AMI). Results were: 1) after AMI, of 83 DH neurons, 18 displayed a significant excitatory response, 14 an obvious inhibitory reaction and 51 no apparent change; 2) after EA at Neiguan (PC 6), of 10 neurons with AMI-induced excitatory response, the electrical activity of 9 neurons was suppressed and the other 1 still maintained its excitatory state;of 8 neurons with AMI-induced inhibitory response, 7 were relieved from the suppressed state, the other 1 had no change following EA; and 3) the receptive field and the responsive types to somatic stimulation were examined in 83 DH neurons. Results showed that signals from EA at Neiguan (PC 6) and AMI could converge to the DH neurons of T2 -T3. It suggests that DH participates in the integrative course of information from EA and AMI and thus it is one of the connective links betwen Neiguan(PC 6) and the heart1012|0|2更新时间：2023-08-11
- 摘要：We observed cyclic nucleotide content of plasma, brain and Spleen tissues when analgesia was produced by acupuncture at the Zusanli. The restrained group without acupuncture was as blank control and acupuncture at Taichong as acupuncture control. We found that after acupuncture at Zusanhi the concentration of cyclic nucleotide in plasma was increased significantly(P<0. 05) and the cAMP concentration of spleen had a tendency of enhancement, but the content of cAMP in the cortex had a tendency of decrease. The concentration of cAMP, cGMP and its ratio cAMP/cGMP was different in cortex and spinal cord between acupuncture at Zusanli and Taichong groups. These results showed that acupuncture at Zusanli and Taichong could induce different changes of concentration of cAMP and cGMP1056|0|1更新时间：2023-08-11
- 摘要：The present paper reports the morphometric analysis of nucleolar organizer regions (NORs) of the adrenal cortex in ovariectomized rats following electroacupuncture (EA) using argyrephil (AgNOR) method for NORs. Animals were divided into four groups, the control group (CT group, n=4), the EA group (n=3), the ovariectomized group (OV group, n=4) and the ovariectomized electroacupuncture group, (OV+EA group, n=7). The number of AgNORs of 100 cells from zona fasciculata of the adrenal cortex in each case of all groups was counted at random and the mean±SE (number/cell)in each group was calculated as follows: OV+EA group 2. 71±0. 26, OV group 1. 62±0. 15, EA group 1. 21 ± 0. 04 and CT group 1. 48±0. 03. The mean of AgNORs in OV+EA group differed highly significantly from the other three groups (P<0. 01) tested by ANOVA and LSD method, No significant distinction was found among the OV group, EA group and CT group.Gross specimen examination showed that adrenal glands in OV+EA were significantly heavier than those in the other three groups (P<0. 01). Vaginal smears showed that a response like that of estrogen-induced with exfoliative cells appeared in the OV+EA group rats following EA.EA had no influence on the change of exfoliative cells in EA group.The results suggest that EA may promote the synthesis and secretion of the adrenal steroid hormones, the androgen of which will then be transformed into estrogen in other tissues, thus compensating the deficiency of estrogen induced by ovariectomy961|0|4更新时间：2023-08-11
- 摘要：The experimental Wistar rats were divided into two groups, the acupuncture group and the control group. Stress-induced gastric ulcer models were established by immersion of restrained rats in water. The results are as follows: 1. Stress-induced peptic ulceration was able to be protected with electroacupuncture. 2.Synthesis and decomposition of central and peripheral 5-HT in the electroacupunctured tats was inhibited. 3. The NE levels in the three brain regions (cortex, hypothalamus,brainstem)and blood were seen in the electroacupuncture group more than that in the control group,but the NE levels was smaller in the gastric tissue. 4. The higher levels of DA in the gastric tissue and blood were seen in the electroacupuncture group than in the control group. The results indicated that protecting rat stress ulceration with electroacupuncture was connected with monoamine neurotransmitter of centre and periphery1062|0|4更新时间：2023-08-11
- 摘要：In this paper, the effects of some analgesic drugs such as corydalis yanhusuo, Angelica dahurica and Analginum on electroacupuncture analgesic function were studied. In the meantime, the concentrations of cytosolic free Ca2+ ([Ca2+]i) in mice hypothalamus (HT) and periaqueductual grey (PAG)were determined by use of the fluorescence dye Fura-2/AM and AR-CM cation measurement system.The results showed that Corydalis yanhusuo obviously strengthened the analgesic function produed by electroacupuncture. Besides, the [Ca2+]i in the two brain regions of mice in these analgesic experiments with electroacupuncture and Corydalis yanhusuo were all decreased (compared with saline control group, P<0. 01), In the same experimental condition, the [Ca2+]i in Angelica dahurica group and Analginum group has no significant difference compared with the control group, the analgesic mechanisms may be different from that of electroacupuncture and Corydalis yanhusuo1000|0|4更新时间：2023-08-11
- 摘要：In the present investigation the intensity of stimulated electro-acupuncture (EA) was measured by electrophysiological collision technique. In the behavioral experiments, by applying the weak electro-acupuncture pulses (50 Hz, 11. 5mA), not enough to activated Aδ afferent fibers, to Yanglingquan and Xuanzhong points, the latency of nociceptive hind limb withdrawal reflex, but not tail -flick latency was prolonged. Administered intraperitoneally, both theophylline and caffeine, P1purinergic (adenosine) receptor antagonists, could block the electroacupuncture-induced elevation of the nociceptive thresholds in a dose-effect related manner, whereas dipyridamole, an inhibitor of adenosine release, could shorten the after effect of electro-acupuncture in a dose dependent way.These results suggest that weak electro-acupuncture may induce analgesia and purines appear to be involved in this process916|0|3更新时间：2023-08-11
- 摘要：The experimental results demonstrated that moxibustion on Guanyuan point could promote the hyperplasia of the pituitary and the adrenal gland which showed atrophy in control group. Also, the moxibustion treatment stimulated the secretion of β-END from the pituitary and the adrenal gland, increased the level of serum β-END significantly and kept the high level for quite a long time, that was advantageous for β-END to carry out the immunomodulation. The data further suggested that moxibustion treatment do not cause the instant release but probably constant release of the β-END931|0|1更新时间：2023-08-11
- 摘要：The present study was to investigate the effect of metoclopramide (MCP) on eletroacupuncture analgesia (EAA) and its mechanism on a rabbit visceral pain model. The results showed that MCP 8mg/kg iv could potentiate EAA and prolong the analgesic duration. The potentiation effect could be attenuated by icv apomorphine (APO) (a mixed D1/D2 agonist). The analgesic duration was shortened by icv SKF38393 (a selective D1 agonist) or LY171555 (a selective D2 agonist). Using HPLCECD, we also found that the HVA content in CSF significantly increased at 20 min. after electroacupuncture (EA) or MCP 8mg/kg iv(P<0.05), but the change of HVA content was not significant when EA and MCP 8mg/kg iv were used together. All these observations indicate that MCP have effects of potentiating EAA and prolonging analgesic duration. These effects are related to the blockade of the central DA receptor. The activations of D1 or D2 receptor is unfavourable to the expression of EA after effect1067|0|0更新时间：2023-08-11
- 摘要：The myoelectric activity of gastro-colon was recorded in 20 rabbits. The model of gastro-colonic disorder was preduced by vena injection of erythromycine (EM) (7mg/kg). We investigated regulating effect of electro-acupuncture (EA) on the disorder of gastrocolonic electric activity (GEA). After the vagotomy the effect of EA was observed. In fasting and anaesthetic rabbits, the frequency and amplitude of GEA were 4. 47±1. 23 cmp, 1. 90±0. 27 mV at antrum, 8. 33±2. 61 cpm, 0. 51±0.12 mV at ascending colon, 6. 74±2. 68 cpm, 0. 35±0. 10 mV at descending colon. After injection of EM, the frequency and amplitude of GEA were increased, the latency and duration of EM effect were 36. 5±4. 5 min and 3. 8±1. 4 min, the great contraction wave was showed. EA could shorten the duration and latency, decrease the frequency, amplitue and variation coefficient of GEA. After vagotomy the effect of EA disappeared. These results indicate that vagus nerve plays an important role in regulating effect of EA on gastro-colonic disorder1017|0|4更新时间：2023-08-11
- 摘要：After an intraperitoneal injection of cyclophosphamide in rats, there was pathologic changes in hemopoietic, immune arid visceral function. Acupuncture respectively at Zusanli, Dazhui and Shenshu points could decrease the above mentioned harms in the rats, the effect of acupuncture on hemopoietio function: Dazhui more than or equal to Zusanli, Zusanli more than Shenshu; the effect of acupuncture on immune function: Zusanli more than Dazhui, Dazhui more than or equal to Shenshu; the effect of acupuncture on the function of the liver and the kidney: Shenshu more than or equal to Zusanli, Zusanli more than Dazhui. The effect of acupuncture at all three points, i. e. Zusanli. Dazhui and Shenshu was more than that at any single point due to their coordination. There was no obvious effect when acupuncture at non-acupoints on tail1014|0|2更新时间：2023-08-11
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